Effects of cyclobeximide, puromycin and actinomycin D on the spontaneous motility of isolated rat uterus

The effect of cycloheximide (2 μg/ml), puromycin (2 μg/ml) and actinomycin D (1 μg/ml), as well as the relation between the influence of cycloheximide and prostaglandin (PG) production on the spontaneous motility of 20 days-ovariectomized rat uterus, were studied. Cycloheximide evoked a more stable...

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Autores principales: Bonacossa, A., Franchi, A.M., Gimeno, M.F., Seara, S.M., Gimeno, A.L.
Formato: JOUR
Materias:
5,8,11,14 icosatetraynoic acid
acetylsalicylic acid
atropine
cycloheptadiene
cycloheximide
cyproheptadine
dactinomycin
indometacin
prostaglandin
puromycin
unclassified drug
animal experiment
article
female genital system
in vitro study
rat
uterus
uterus contractility
Animals
Aspirin
Castration
Cycloheximide
Dactinomycin
Drug Interactions
Female
Prostaglandins
Puromycin
Rats
Rats, Inbred Strains
Time Factors
Uterine Contraction
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00316989_v14_n5_p455_Bonacossa
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_00316989_v14_n5_p455_Bonacossa
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spelling todo:paper_00316989_v14_n5_p455_Bonacossa2023-10-03T14:41:26Z Effects of cyclobeximide, puromycin and actinomycin D on the spontaneous motility of isolated rat uterus Bonacossa, A. Franchi, A.M. Gimeno, M.F. Seara, S.M. Gimeno, A.L. 5,8,11,14 icosatetraynoic acid acetylsalicylic acid atropine cycloheptadiene cycloheximide cyproheptadine dactinomycin indometacin prostaglandin puromycin unclassified drug animal experiment article female genital system in vitro study rat uterus uterus contractility Animals Aspirin Castration Cycloheximide Dactinomycin Drug Interactions Female Prostaglandins Puromycin Rats Rats, Inbred Strains Time Factors Uterine Contraction The effect of cycloheximide (2 μg/ml), puromycin (2 μg/ml) and actinomycin D (1 μg/ml), as well as the relation between the influence of cycloheximide and prostaglandin (PG) production on the spontaneous motility of 20 days-ovariectomized rat uterus, were studied. Cycloheximide evoked a more stable motility during the experimental period (180 min) when compared with controls. Neither puromycin nor actinomycin D could madify the spontaneous activity. In the presence of cycloheximide, the rat uterus released more PGE-like material than the untreated one, and no differences were found in the generation of PGF-like material. Indomethacin, acetylsalicylic acid and eicosa-5,8,11, 14- tetraynoic acid could partially block the cycloheximide-induced constancy of motility of uterine strips. Cyproheptadine and atropine had no effect at all. It is suggested that cycloheximide prevents the spontaneoys decay of the contractile activity at least in part by influencing PGE-like material production. © 1982 The Italian Pharmacological Society. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00316989_v14_n5_p455_Bonacossa
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic 5,8,11,14 icosatetraynoic acid
acetylsalicylic acid
atropine
cycloheptadiene
cycloheximide
cyproheptadine
dactinomycin
indometacin
prostaglandin
puromycin
unclassified drug
animal experiment
article
female genital system
in vitro study
rat
uterus
uterus contractility
Animals
Aspirin
Castration
Cycloheximide
Dactinomycin
Drug Interactions
Female
Prostaglandins
Puromycin
Rats
Rats, Inbred Strains
Time Factors
Uterine Contraction
spellingShingle 5,8,11,14 icosatetraynoic acid
acetylsalicylic acid
atropine
cycloheptadiene
cycloheximide
cyproheptadine
dactinomycin
indometacin
prostaglandin
puromycin
unclassified drug
animal experiment
article
female genital system
in vitro study
rat
uterus
uterus contractility
Animals
Aspirin
Castration
Cycloheximide
Dactinomycin
Drug Interactions
Female
Prostaglandins
Puromycin
Rats
Rats, Inbred Strains
Time Factors
Uterine Contraction
Bonacossa, A.
Franchi, A.M.
Gimeno, M.F.
Seara, S.M.
Gimeno, A.L.
Effects of cyclobeximide, puromycin and actinomycin D on the spontaneous motility of isolated rat uterus
topic_facet 5,8,11,14 icosatetraynoic acid
acetylsalicylic acid
atropine
cycloheptadiene
cycloheximide
cyproheptadine
dactinomycin
indometacin
prostaglandin
puromycin
unclassified drug
animal experiment
article
female genital system
in vitro study
rat
uterus
uterus contractility
Animals
Aspirin
Castration
Cycloheximide
Dactinomycin
Drug Interactions
Female
Prostaglandins
Puromycin
Rats
Rats, Inbred Strains
Time Factors
Uterine Contraction
description The effect of cycloheximide (2 μg/ml), puromycin (2 μg/ml) and actinomycin D (1 μg/ml), as well as the relation between the influence of cycloheximide and prostaglandin (PG) production on the spontaneous motility of 20 days-ovariectomized rat uterus, were studied. Cycloheximide evoked a more stable motility during the experimental period (180 min) when compared with controls. Neither puromycin nor actinomycin D could madify the spontaneous activity. In the presence of cycloheximide, the rat uterus released more PGE-like material than the untreated one, and no differences were found in the generation of PGF-like material. Indomethacin, acetylsalicylic acid and eicosa-5,8,11, 14- tetraynoic acid could partially block the cycloheximide-induced constancy of motility of uterine strips. Cyproheptadine and atropine had no effect at all. It is suggested that cycloheximide prevents the spontaneoys decay of the contractile activity at least in part by influencing PGE-like material production. © 1982 The Italian Pharmacological Society.
format JOUR
author Bonacossa, A.
Franchi, A.M.
Gimeno, M.F.
Seara, S.M.
Gimeno, A.L.
author_facet Bonacossa, A.
Franchi, A.M.
Gimeno, M.F.
Seara, S.M.
Gimeno, A.L.
author_sort Bonacossa, A.
title Effects of cyclobeximide, puromycin and actinomycin D on the spontaneous motility of isolated rat uterus
title_short Effects of cyclobeximide, puromycin and actinomycin D on the spontaneous motility of isolated rat uterus
title_full Effects of cyclobeximide, puromycin and actinomycin D on the spontaneous motility of isolated rat uterus
title_fullStr Effects of cyclobeximide, puromycin and actinomycin D on the spontaneous motility of isolated rat uterus
title_full_unstemmed Effects of cyclobeximide, puromycin and actinomycin D on the spontaneous motility of isolated rat uterus
title_sort effects of cyclobeximide, puromycin and actinomycin d on the spontaneous motility of isolated rat uterus
url http://hdl.handle.net/20.500.12110/paper_00316989_v14_n5_p455_Bonacossa
work_keys_str_mv AT bonacossaa effectsofcyclobeximidepuromycinandactinomycindonthespontaneousmotilityofisolatedratuterus
AT franchiam effectsofcyclobeximidepuromycinandactinomycindonthespontaneousmotilityofisolatedratuterus
AT gimenomf effectsofcyclobeximidepuromycinandactinomycindonthespontaneousmotilityofisolatedratuterus
AT searasm effectsofcyclobeximidepuromycinandactinomycindonthespontaneousmotilityofisolatedratuterus
AT gimenoal effectsofcyclobeximidepuromycinandactinomycindonthespontaneousmotilityofisolatedratuterus
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