A different contractile response to catecholamines of two regions (mesometrial and antimesometrial) of isolated rat uterine horns

The contractile reactivity to sympathetic agonists of two different regions of the rat uterus: mesometrial (M) and antimesometrial or lines uteri (LU), was studied. The inhibitory effects of the adrenergic agonists on the spontaneous as well as on the oxytocin-triggered activity were greater in the...

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Detalles Bibliográficos
Autores principales: Sterin-Speziale, N., Gimeno, M.F., Borda, E., Chaud, M., Gimeno, A.L.
Formato: JOUR
Materias:
isoprenaline
noradrenalin
oxytocin
phentolamine
phentolamine mesylate
phenylephrine
sotalol
animal experiment
female genital system
in vitro study
muscle
rat
smooth muscle contraction
uterus contractility
uterus contraction
uterus horn
Animals
Catecholamines
Dose-Response Relationship, Drug
Female
Isoproterenol
Norepinephrine
Oxytocin
Phenylephrine
Rats
Rats, Inbred Strains
Receptors, Adrenergic
Sympatholytics
Uterine Contraction
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00316989_v13_n4_p401_SterinSpeziale
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:The contractile reactivity to sympathetic agonists of two different regions of the rat uterus: mesometrial (M) and antimesometrial or lines uteri (LU), was studied. The inhibitory effects of the adrenergic agonists on the spontaneous as well as on the oxytocin-triggered activity were greater in the M region than in the LU. Beta-adrenoceptor blocking agents abolished the different sensitivity towards the adrenergic agonists between both zones. The results suggest that in the M region there is a higher population of beta adrenoceptors or an augmented affinity of the agonist for them than in the LU. © 1981 The Italian Pharmacological Society.

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