Molecular phylogeny based on six nuclear genes suggests that Echinococcus granulosus sensu lato genotypes G6/G7 and G8/G10 can be regarded as two distinct species

Tapeworms of the species complex of Echinococcus granulosus sensu lato (s. l.) are the cause of a severe zoonotic disease – cystic echinococcosis, which is listed among the most severe parasitic diseases in humans and is prioritized by the World Health Organization. A stable taxonomy of E. granulosu...

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Autores principales: Laurimäe, T., Kinkar, L., Moks, E., Romig, T., Omer, R.A., Casulli, A., Umhang, G., Bagrade, G., Irshadullah, M., Sharbatkhori, M., Mirhendi, H., Ponce-Gordo, F., Soriano, S.V., Varcasia, A., Rostami-Nejad, M., Andresiuk, V., Saarma, U.
Formato: INPR
Materias:
Cystic echinococcosis
hydatid disease
nuclear genes
nuclear phylogeny
zoonosis
zoonotic pathogens
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00311820_v_n_p1_Laurimae
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
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spelling todo:paper_00311820_v_n_p1_Laurimae2023-10-03T14:41:17Z Molecular phylogeny based on six nuclear genes suggests that Echinococcus granulosus sensu lato genotypes G6/G7 and G8/G10 can be regarded as two distinct species Laurimäe, T. Kinkar, L. Moks, E. Romig, T. Omer, R.A. Casulli, A. Umhang, G. Bagrade, G. Irshadullah, M. Sharbatkhori, M. Mirhendi, H. Ponce-Gordo, F. Soriano, S.V. Varcasia, A. Rostami-Nejad, M. Andresiuk, V. Saarma, U. Cystic echinococcosis hydatid disease nuclear genes nuclear phylogeny zoonosis zoonotic pathogens Tapeworms of the species complex of Echinococcus granulosus sensu lato (s. l.) are the cause of a severe zoonotic disease – cystic echinococcosis, which is listed among the most severe parasitic diseases in humans and is prioritized by the World Health Organization. A stable taxonomy of E. granulosus s. l. is essential to the medical and veterinary communities for accurate and effective communication of the role of different species in this complex on human and animal health. E. granulosus s. l. displays high genetic diversity and has been divided into different species and genotypes. Despite several decades of research, the taxonomy of E. granulosus s. l. has remained controversial, especially the species status of genotypes G6–G10. Here the Bayesian phylogeny based on six nuclear loci (7387 bp in total) demonstrated, with very high support, the clustering of G6/G7 and G8/G10 into two separate clades. According to the evolutionary species concept, G6/G7 and G8/G10 can be regarded as two distinct species. Species differentiation can be attributed to the association with distinct host species, largely separate geographical distribution and low level of cross-fertilization. These factors have limited the gene flow between genotypic groups G6/G7 and G8/G10, resulting in the formation of distinct species. We discuss ecological and epidemiological differences that support the validity of these species. Copyright © Cambridge University Press 2018 INPR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00311820_v_n_p1_Laurimae
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Cystic echinococcosis
hydatid disease
nuclear genes
nuclear phylogeny
zoonosis
zoonotic pathogens
spellingShingle Cystic echinococcosis
hydatid disease
nuclear genes
nuclear phylogeny
zoonosis
zoonotic pathogens
Laurimäe, T.
Kinkar, L.
Moks, E.
Romig, T.
Omer, R.A.
Casulli, A.
Umhang, G.
Bagrade, G.
Irshadullah, M.
Sharbatkhori, M.
Mirhendi, H.
Ponce-Gordo, F.
Soriano, S.V.
Varcasia, A.
Rostami-Nejad, M.
Andresiuk, V.
Saarma, U.
Molecular phylogeny based on six nuclear genes suggests that Echinococcus granulosus sensu lato genotypes G6/G7 and G8/G10 can be regarded as two distinct species
topic_facet Cystic echinococcosis
hydatid disease
nuclear genes
nuclear phylogeny
zoonosis
zoonotic pathogens
description Tapeworms of the species complex of Echinococcus granulosus sensu lato (s. l.) are the cause of a severe zoonotic disease – cystic echinococcosis, which is listed among the most severe parasitic diseases in humans and is prioritized by the World Health Organization. A stable taxonomy of E. granulosus s. l. is essential to the medical and veterinary communities for accurate and effective communication of the role of different species in this complex on human and animal health. E. granulosus s. l. displays high genetic diversity and has been divided into different species and genotypes. Despite several decades of research, the taxonomy of E. granulosus s. l. has remained controversial, especially the species status of genotypes G6–G10. Here the Bayesian phylogeny based on six nuclear loci (7387 bp in total) demonstrated, with very high support, the clustering of G6/G7 and G8/G10 into two separate clades. According to the evolutionary species concept, G6/G7 and G8/G10 can be regarded as two distinct species. Species differentiation can be attributed to the association with distinct host species, largely separate geographical distribution and low level of cross-fertilization. These factors have limited the gene flow between genotypic groups G6/G7 and G8/G10, resulting in the formation of distinct species. We discuss ecological and epidemiological differences that support the validity of these species. Copyright © Cambridge University Press 2018
format INPR
author Laurimäe, T.
Kinkar, L.
Moks, E.
Romig, T.
Omer, R.A.
Casulli, A.
Umhang, G.
Bagrade, G.
Irshadullah, M.
Sharbatkhori, M.
Mirhendi, H.
Ponce-Gordo, F.
Soriano, S.V.
Varcasia, A.
Rostami-Nejad, M.
Andresiuk, V.
Saarma, U.
author_facet Laurimäe, T.
Kinkar, L.
Moks, E.
Romig, T.
Omer, R.A.
Casulli, A.
Umhang, G.
Bagrade, G.
Irshadullah, M.
Sharbatkhori, M.
Mirhendi, H.
Ponce-Gordo, F.
Soriano, S.V.
Varcasia, A.
Rostami-Nejad, M.
Andresiuk, V.
Saarma, U.
author_sort Laurimäe, T.
title Molecular phylogeny based on six nuclear genes suggests that Echinococcus granulosus sensu lato genotypes G6/G7 and G8/G10 can be regarded as two distinct species
title_short Molecular phylogeny based on six nuclear genes suggests that Echinococcus granulosus sensu lato genotypes G6/G7 and G8/G10 can be regarded as two distinct species
title_full Molecular phylogeny based on six nuclear genes suggests that Echinococcus granulosus sensu lato genotypes G6/G7 and G8/G10 can be regarded as two distinct species
title_fullStr Molecular phylogeny based on six nuclear genes suggests that Echinococcus granulosus sensu lato genotypes G6/G7 and G8/G10 can be regarded as two distinct species
title_full_unstemmed Molecular phylogeny based on six nuclear genes suggests that Echinococcus granulosus sensu lato genotypes G6/G7 and G8/G10 can be regarded as two distinct species
title_sort molecular phylogeny based on six nuclear genes suggests that echinococcus granulosus sensu lato genotypes g6/g7 and g8/g10 can be regarded as two distinct species
url http://hdl.handle.net/20.500.12110/paper_00311820_v_n_p1_Laurimae
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