Analysis of the transmission of Trypanosoma cruzi infection through hosts and vectors
Calculating epidemiological measures of infection by Trypanosoma cruzi, the causative agent of Chagas disease, is complex, because it involves several species, different stages of infection in humans and multiple transmission routes. Using the next-generation matrix method, we analysed a model which...
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todo:paper_00311820_v143_n9_p1168_Fabrizio2023-10-03T14:41:16Z Analysis of the transmission of Trypanosoma cruzi infection through hosts and vectors Fabrizio, M.C. Schweigmann, N.J. Bartoloni, N.J. Chagas disease mathematical model next-generation matrix Trypanosoma cruzi Article Chagas disease disease transmission host human infection nonhuman priority journal Trypanosoma cruzi animal Argentina biological model Chagas disease disease carrier dog Dog Diseases endemic disease insect vector parasitology physiology rural population theoretical model transmission Triatominae Animals Argentina Chagas Disease Disease Reservoirs Dog Diseases Dogs Endemic Diseases Humans Insect Vectors Models, Biological Models, Theoretical Rural Population Triatominae Trypanosoma cruzi Calculating epidemiological measures of infection by Trypanosoma cruzi, the causative agent of Chagas disease, is complex, because it involves several species, different stages of infection in humans and multiple transmission routes. Using the next-generation matrix method, we analysed a model which considers the three stages of human infection, triatomines and dogs (the main domestic reservoirs of T. cruzi when triatomines are present) and the main transmission routes. We derived R 0 and type-reproduction numbers T. We deduced formulas for the number of new infections generated through each transmission route by each infected individual. We applied our findings in Argentine Gran Chaco. The expressions achieved allowed quantifying the high infectivity of dogs and emphasizing the epidemiological importance of the long and asymptomatic chronic indeterminate stage in humans in the spread of the infection. According to the model, it is expected that one infected human infects 21 triatomines, that 100 infected triatomines are necessary to infect one human and 34 to infect a dog, and that each dog infects on average one triatomine per day. Our results may allow quantifying the effect of control measures on infected humans, triatomines and dogs (or other highly infected vertebrate) or on a specific route of transmission, in other scenarios. © Cambridge University Press 2016. Fil:Fabrizio, M.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Schweigmann, N.J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00311820_v143_n9_p1168_Fabrizio |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Chagas disease mathematical model next-generation matrix Trypanosoma cruzi Article Chagas disease disease transmission host human infection nonhuman priority journal Trypanosoma cruzi animal Argentina biological model Chagas disease disease carrier dog Dog Diseases endemic disease insect vector parasitology physiology rural population theoretical model transmission Triatominae Animals Argentina Chagas Disease Disease Reservoirs Dog Diseases Dogs Endemic Diseases Humans Insect Vectors Models, Biological Models, Theoretical Rural Population Triatominae Trypanosoma cruzi |
| spellingShingle |
Chagas disease mathematical model next-generation matrix Trypanosoma cruzi Article Chagas disease disease transmission host human infection nonhuman priority journal Trypanosoma cruzi animal Argentina biological model Chagas disease disease carrier dog Dog Diseases endemic disease insect vector parasitology physiology rural population theoretical model transmission Triatominae Animals Argentina Chagas Disease Disease Reservoirs Dog Diseases Dogs Endemic Diseases Humans Insect Vectors Models, Biological Models, Theoretical Rural Population Triatominae Trypanosoma cruzi Fabrizio, M.C. Schweigmann, N.J. Bartoloni, N.J. Analysis of the transmission of Trypanosoma cruzi infection through hosts and vectors |
| topic_facet |
Chagas disease mathematical model next-generation matrix Trypanosoma cruzi Article Chagas disease disease transmission host human infection nonhuman priority journal Trypanosoma cruzi animal Argentina biological model Chagas disease disease carrier dog Dog Diseases endemic disease insect vector parasitology physiology rural population theoretical model transmission Triatominae Animals Argentina Chagas Disease Disease Reservoirs Dog Diseases Dogs Endemic Diseases Humans Insect Vectors Models, Biological Models, Theoretical Rural Population Triatominae Trypanosoma cruzi |
| description |
Calculating epidemiological measures of infection by Trypanosoma cruzi, the causative agent of Chagas disease, is complex, because it involves several species, different stages of infection in humans and multiple transmission routes. Using the next-generation matrix method, we analysed a model which considers the three stages of human infection, triatomines and dogs (the main domestic reservoirs of T. cruzi when triatomines are present) and the main transmission routes. We derived R 0 and type-reproduction numbers T. We deduced formulas for the number of new infections generated through each transmission route by each infected individual. We applied our findings in Argentine Gran Chaco. The expressions achieved allowed quantifying the high infectivity of dogs and emphasizing the epidemiological importance of the long and asymptomatic chronic indeterminate stage in humans in the spread of the infection. According to the model, it is expected that one infected human infects 21 triatomines, that 100 infected triatomines are necessary to infect one human and 34 to infect a dog, and that each dog infects on average one triatomine per day. Our results may allow quantifying the effect of control measures on infected humans, triatomines and dogs (or other highly infected vertebrate) or on a specific route of transmission, in other scenarios. © Cambridge University Press 2016. |
| format |
JOUR |
| author |
Fabrizio, M.C. Schweigmann, N.J. Bartoloni, N.J. |
| author_facet |
Fabrizio, M.C. Schweigmann, N.J. Bartoloni, N.J. |
| author_sort |
Fabrizio, M.C. |
| title |
Analysis of the transmission of Trypanosoma cruzi infection through hosts and vectors |
| title_short |
Analysis of the transmission of Trypanosoma cruzi infection through hosts and vectors |
| title_full |
Analysis of the transmission of Trypanosoma cruzi infection through hosts and vectors |
| title_fullStr |
Analysis of the transmission of Trypanosoma cruzi infection through hosts and vectors |
| title_full_unstemmed |
Analysis of the transmission of Trypanosoma cruzi infection through hosts and vectors |
| title_sort |
analysis of the transmission of trypanosoma cruzi infection through hosts and vectors |
| url |
http://hdl.handle.net/20.500.12110/paper_00311820_v143_n9_p1168_Fabrizio |
| work_keys_str_mv |
AT fabriziomc analysisofthetransmissionoftrypanosomacruziinfectionthroughhostsandvectors AT schweigmannnj analysisofthetransmissionoftrypanosomacruziinfectionthroughhostsandvectors AT bartoloninj analysisofthetransmissionoftrypanosomacruziinfectionthroughhostsandvectors |
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