State-dependent changes of connectivity patterns and functional brain network topology in autism spectrum disorder

Anatomical and functional brain studies have converged to the hypothesis that autism spectrum disorders (ASD) are associated with atypical connectivity. Using a modified resting-state paradigm to drive subjects' attention, we provide evidence of a very marked interaction between ASD brain funct...

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Autores principales:	Barttfeld, P., Wicker, B., Cukier, S., Navarta, S., Lew, S., Leiguarda, R., Sigman, M.
Formato:	JOUR
Materias:	ADOS score Autism spectrum disorders Brain states Functional connectivity adult angular gyrus anterior cingulate anterior insula article attention autism basal ganglion brain region clinical article cognition controlled study disease association disease severity DSM-IV female functional magnetic resonance imaging human inferior parietal lobule inferior temporal cortex male precuneus prefrontal cortex state dependent learning Adolescent Attention Deficit Disorder with Hyperactivity Brain Brain Mapping Child Child Development Disorders, Pervasive Humans Image Processing, Computer-Assisted Magnetic Resonance Imaging Neural Pathways Oxygen Rest Young Adult
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_00283932_v50_n14_p3653_Barttfeld
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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spelling	todo:paper_00283932_v50_n14_p3653_Barttfeld2023-10-03T14:39:06Z State-dependent changes of connectivity patterns and functional brain network topology in autism spectrum disorder Barttfeld, P. Wicker, B. Cukier, S. Navarta, S. Lew, S. Leiguarda, R. Sigman, M. ADOS score Autism spectrum disorders Brain states Functional connectivity adult angular gyrus anterior cingulate anterior insula article attention autism basal ganglion brain region clinical article cognition controlled study disease association disease severity DSM-IV female functional magnetic resonance imaging human inferior parietal lobule inferior temporal cortex male precuneus prefrontal cortex state dependent learning Adolescent Attention Deficit Disorder with Hyperactivity Brain Brain Mapping Child Child Development Disorders, Pervasive Humans Image Processing, Computer-Assisted Magnetic Resonance Imaging Neural Pathways Oxygen Rest Young Adult Anatomical and functional brain studies have converged to the hypothesis that autism spectrum disorders (ASD) are associated with atypical connectivity. Using a modified resting-state paradigm to drive subjects' attention, we provide evidence of a very marked interaction between ASD brain functional connectivity and cognitive state. We show that functional connectivity changes in opposite ways in ASD and typicals as attention shifts from external world towards one's body generated information. Furthermore, ASD subject alter more markedly than typicals their connectivity across cognitive states. Using differences in brain connectivity across conditions, we ranked brain regions according to their classification power. Anterior insula and dorsal-anterior cingulate cortex were the regions that better characterize ASD differences with typical subjects across conditions, and this effect was modulated by ASD severity. These results pave the path for diagnosis of mental pathologies based on functional brain networks obtained from a library of mental states. © 2012 Elsevier Ltd. Fil:Leiguarda, R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Sigman, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00283932_v50_n14_p3653_Barttfeld
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	ADOS score Autism spectrum disorders Brain states Functional connectivity adult angular gyrus anterior cingulate anterior insula article attention autism basal ganglion brain region clinical article cognition controlled study disease association disease severity DSM-IV female functional magnetic resonance imaging human inferior parietal lobule inferior temporal cortex male precuneus prefrontal cortex state dependent learning Adolescent Attention Deficit Disorder with Hyperactivity Brain Brain Mapping Child Child Development Disorders, Pervasive Humans Image Processing, Computer-Assisted Magnetic Resonance Imaging Neural Pathways Oxygen Rest Young Adult
spellingShingle	ADOS score Autism spectrum disorders Brain states Functional connectivity adult angular gyrus anterior cingulate anterior insula article attention autism basal ganglion brain region clinical article cognition controlled study disease association disease severity DSM-IV female functional magnetic resonance imaging human inferior parietal lobule inferior temporal cortex male precuneus prefrontal cortex state dependent learning Adolescent Attention Deficit Disorder with Hyperactivity Brain Brain Mapping Child Child Development Disorders, Pervasive Humans Image Processing, Computer-Assisted Magnetic Resonance Imaging Neural Pathways Oxygen Rest Young Adult Barttfeld, P. Wicker, B. Cukier, S. Navarta, S. Lew, S. Leiguarda, R. Sigman, M. State-dependent changes of connectivity patterns and functional brain network topology in autism spectrum disorder
topic_facet	ADOS score Autism spectrum disorders Brain states Functional connectivity adult angular gyrus anterior cingulate anterior insula article attention autism basal ganglion brain region clinical article cognition controlled study disease association disease severity DSM-IV female functional magnetic resonance imaging human inferior parietal lobule inferior temporal cortex male precuneus prefrontal cortex state dependent learning Adolescent Attention Deficit Disorder with Hyperactivity Brain Brain Mapping Child Child Development Disorders, Pervasive Humans Image Processing, Computer-Assisted Magnetic Resonance Imaging Neural Pathways Oxygen Rest Young Adult
description	Anatomical and functional brain studies have converged to the hypothesis that autism spectrum disorders (ASD) are associated with atypical connectivity. Using a modified resting-state paradigm to drive subjects' attention, we provide evidence of a very marked interaction between ASD brain functional connectivity and cognitive state. We show that functional connectivity changes in opposite ways in ASD and typicals as attention shifts from external world towards one's body generated information. Furthermore, ASD subject alter more markedly than typicals their connectivity across cognitive states. Using differences in brain connectivity across conditions, we ranked brain regions according to their classification power. Anterior insula and dorsal-anterior cingulate cortex were the regions that better characterize ASD differences with typical subjects across conditions, and this effect was modulated by ASD severity. These results pave the path for diagnosis of mental pathologies based on functional brain networks obtained from a library of mental states. © 2012 Elsevier Ltd.
format	JOUR
author	Barttfeld, P. Wicker, B. Cukier, S. Navarta, S. Lew, S. Leiguarda, R. Sigman, M.
author_facet	Barttfeld, P. Wicker, B. Cukier, S. Navarta, S. Lew, S. Leiguarda, R. Sigman, M.
author_sort	Barttfeld, P.
title	State-dependent changes of connectivity patterns and functional brain network topology in autism spectrum disorder
title_short	State-dependent changes of connectivity patterns and functional brain network topology in autism spectrum disorder
title_full	State-dependent changes of connectivity patterns and functional brain network topology in autism spectrum disorder
title_fullStr	State-dependent changes of connectivity patterns and functional brain network topology in autism spectrum disorder
title_full_unstemmed	State-dependent changes of connectivity patterns and functional brain network topology in autism spectrum disorder
title_sort	state-dependent changes of connectivity patterns and functional brain network topology in autism spectrum disorder
url	http://hdl.handle.net/20.500.12110/paper_00283932_v50_n14_p3653_Barttfeld
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_version_	1782031071208013824

State-dependent changes of connectivity patterns and functional brain network topology in autism spectrum disorder

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