Effect of pentoxifylline on α- and β-adrenoceptor sites in cerebral cortex, medial basal hypothalamus and pineal gland of the rat
The intraperitoneal injection of the methylxanthine derivative pentoxifylline [3,7-dimethyl-1-(5-oxo-hexyl)-xanthine] brought about, 3 hr later, a significant depression of α- and β-adrenoceptor sites in the cerebral cortex, and of β-adrenoceptor sites in medial basal hypothalamus and pineal gland,...
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todo:paper_00283908_v21_n3_p243_Lowenstein2023-10-03T14:39:02Z Effect of pentoxifylline on α- and β-adrenoceptor sites in cerebral cortex, medial basal hypothalamus and pineal gland of the rat Lowenstein, P.R. Vacas, M.I. Cardinali, D.P. adrenergic receptors binding studies cerebral cortex medial basal hypothalamus pentoxifylline [3,7-dimethyl-1-(5-oxo-hexyl)-xanthine], methylxanthines pineal gland superior cervical ganglion alpha adrenergic receptor beta adrenergic receptor dihydroergocryptine drug receptor pentoxifylline phentolamine propranolol radioisotope animal experiment brain cortex central nervous system dihydroalprenolol h 3 dihydroergocryptine h 3 hypothalamus pineal body rat Animal Binding Sites Cerebral Cortex Dihydroalprenolol Dihydroergotoxine Female Hypothalamus Pentoxifylline Pineal Gland Rats Rats, Inbred Strains Receptors, Adrenergic Receptors, Adrenergic, alpha Receptors, Adrenergic, beta Support, Non-U.S. Gov't Theobromine The intraperitoneal injection of the methylxanthine derivative pentoxifylline [3,7-dimethyl-1-(5-oxo-hexyl)-xanthine] brought about, 3 hr later, a significant depression of α- and β-adrenoceptor sites in the cerebral cortex, and of β-adrenoceptor sites in medial basal hypothalamus and pineal gland, (assessed from the specific binding of radioactive dihydroergocryptine and dihydroalprenolol respectively). The changes in the density of binding sites were not accompanied by significant modifications of the Kd′s. Sympathetic denervation of the pineal gland by superior cervical ganglionectomy (SCGx) abolished the changes of β-adrenoceptor number in the pineal caused by pentoxifylline. The increase of α-adrenoceptor sites in the hypothalamus brought about by ganglionectomy was not affected by injection of pentoxifylline. Pentoxifylline did not compete in vitro for radioligand binding to brain membranes. These results suggest that methylxanthines depress brain adrenoceptor sites acutely, probably by down-regulation of receptors following the increase in catecholamine release caused by injection of the drug. © 1982. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00283908_v21_n3_p243_Lowenstein |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
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R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
adrenergic receptors binding studies cerebral cortex medial basal hypothalamus pentoxifylline [3,7-dimethyl-1-(5-oxo-hexyl)-xanthine], methylxanthines pineal gland superior cervical ganglion alpha adrenergic receptor beta adrenergic receptor dihydroergocryptine drug receptor pentoxifylline phentolamine propranolol radioisotope animal experiment brain cortex central nervous system dihydroalprenolol h 3 dihydroergocryptine h 3 hypothalamus pineal body rat Animal Binding Sites Cerebral Cortex Dihydroalprenolol Dihydroergotoxine Female Hypothalamus Pentoxifylline Pineal Gland Rats Rats, Inbred Strains Receptors, Adrenergic Receptors, Adrenergic, alpha Receptors, Adrenergic, beta Support, Non-U.S. Gov't Theobromine |
| spellingShingle |
adrenergic receptors binding studies cerebral cortex medial basal hypothalamus pentoxifylline [3,7-dimethyl-1-(5-oxo-hexyl)-xanthine], methylxanthines pineal gland superior cervical ganglion alpha adrenergic receptor beta adrenergic receptor dihydroergocryptine drug receptor pentoxifylline phentolamine propranolol radioisotope animal experiment brain cortex central nervous system dihydroalprenolol h 3 dihydroergocryptine h 3 hypothalamus pineal body rat Animal Binding Sites Cerebral Cortex Dihydroalprenolol Dihydroergotoxine Female Hypothalamus Pentoxifylline Pineal Gland Rats Rats, Inbred Strains Receptors, Adrenergic Receptors, Adrenergic, alpha Receptors, Adrenergic, beta Support, Non-U.S. Gov't Theobromine Lowenstein, P.R. Vacas, M.I. Cardinali, D.P. Effect of pentoxifylline on α- and β-adrenoceptor sites in cerebral cortex, medial basal hypothalamus and pineal gland of the rat |
| topic_facet |
adrenergic receptors binding studies cerebral cortex medial basal hypothalamus pentoxifylline [3,7-dimethyl-1-(5-oxo-hexyl)-xanthine], methylxanthines pineal gland superior cervical ganglion alpha adrenergic receptor beta adrenergic receptor dihydroergocryptine drug receptor pentoxifylline phentolamine propranolol radioisotope animal experiment brain cortex central nervous system dihydroalprenolol h 3 dihydroergocryptine h 3 hypothalamus pineal body rat Animal Binding Sites Cerebral Cortex Dihydroalprenolol Dihydroergotoxine Female Hypothalamus Pentoxifylline Pineal Gland Rats Rats, Inbred Strains Receptors, Adrenergic Receptors, Adrenergic, alpha Receptors, Adrenergic, beta Support, Non-U.S. Gov't Theobromine |
| description |
The intraperitoneal injection of the methylxanthine derivative pentoxifylline [3,7-dimethyl-1-(5-oxo-hexyl)-xanthine] brought about, 3 hr later, a significant depression of α- and β-adrenoceptor sites in the cerebral cortex, and of β-adrenoceptor sites in medial basal hypothalamus and pineal gland, (assessed from the specific binding of radioactive dihydroergocryptine and dihydroalprenolol respectively). The changes in the density of binding sites were not accompanied by significant modifications of the Kd′s. Sympathetic denervation of the pineal gland by superior cervical ganglionectomy (SCGx) abolished the changes of β-adrenoceptor number in the pineal caused by pentoxifylline. The increase of α-adrenoceptor sites in the hypothalamus brought about by ganglionectomy was not affected by injection of pentoxifylline. Pentoxifylline did not compete in vitro for radioligand binding to brain membranes. These results suggest that methylxanthines depress brain adrenoceptor sites acutely, probably by down-regulation of receptors following the increase in catecholamine release caused by injection of the drug. © 1982. |
| format |
JOUR |
| author |
Lowenstein, P.R. Vacas, M.I. Cardinali, D.P. |
| author_facet |
Lowenstein, P.R. Vacas, M.I. Cardinali, D.P. |
| author_sort |
Lowenstein, P.R. |
| title |
Effect of pentoxifylline on α- and β-adrenoceptor sites in cerebral cortex, medial basal hypothalamus and pineal gland of the rat |
| title_short |
Effect of pentoxifylline on α- and β-adrenoceptor sites in cerebral cortex, medial basal hypothalamus and pineal gland of the rat |
| title_full |
Effect of pentoxifylline on α- and β-adrenoceptor sites in cerebral cortex, medial basal hypothalamus and pineal gland of the rat |
| title_fullStr |
Effect of pentoxifylline on α- and β-adrenoceptor sites in cerebral cortex, medial basal hypothalamus and pineal gland of the rat |
| title_full_unstemmed |
Effect of pentoxifylline on α- and β-adrenoceptor sites in cerebral cortex, medial basal hypothalamus and pineal gland of the rat |
| title_sort |
effect of pentoxifylline on α- and β-adrenoceptor sites in cerebral cortex, medial basal hypothalamus and pineal gland of the rat |
| url |
http://hdl.handle.net/20.500.12110/paper_00283908_v21_n3_p243_Lowenstein |
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