Effect of bilateral denervation of the immature rat testis on testicular gonadotropin receptors and in vitro

We have studied the effect of superior spermatic nerve (SSN) section on testicular gonadotropin receptors and in vitro androgen production by immature rat testis. Bilateral testicular denervation had no effect on testicular weight, serum androgens, LH, FSH and PRL levels. Denervation resulted in a s...

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Detalles Bibliográficos
Autores principales: Campos, M.B., Chiocchio, S.R., Calandra, R.S., Ritta, M.N.
Formato: JOUR
Materias:
Androgen production
Gonadotropin receptors
Testicular denervation
Testis
chorionic gonadotropin
follitropin receptor
gonadotropin receptor
iodine 125
luteinizing hormone receptor
membrane receptor
androgen blood level
androgen synthesis
animal cell
animal tissue
article
controlled study
denervation
follitropin blood level
hormone inhibition
immaturity
isotope labeling
luteinizing hormone blood level
male
nerve transection
nonhuman
priority journal
prolactin blood level
radioimmunoassay
rat
spermatozoon
steroidogenesis
testis
testis development
testis weight
testosterone blood level
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00283835_v57_n2_p189_Campos
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:We have studied the effect of superior spermatic nerve (SSN) section on testicular gonadotropin receptors and in vitro androgen production by immature rat testis. Bilateral testicular denervation had no effect on testicular weight, serum androgens, LH, FSH and PRL levels. Denervation resulted in a significant inhibition of hCG stimulated in vitro androgen production. A reduction in the number of testicular LH receptors was observed after SSN section, while FSH binding sites remained unchanged. These results indicate that the number of LH receptors and testicular steroidogenic response to hCG are influenced by nerves reaching the testis.

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