Involvement of 5-lipoxygenase pathway in norepinephrine stimulation of rat pineal melatonin synthesis

The effect of lipoxygenase inhibition, leukotriene agonists and antagonists, and 5-hydroxy-6, 8, l 1, 14-eicosate-traenoic acid (5-HF.TE) was examined in the rat pineal gland in organ culture. To study melatonin secretion pineal explants were incubated for 6 h in tissue culture medium 199 with the d...

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Autores principales:	Vacas, M.I., Keller-Sarmiento, M.I., Etchegoyen, G.S., Pereyra, E.N., Gimeno, M.F., Cardinali, D.P.
Formato:	JOUR
Materias:	Leukotriene antagonists Leukotrienes Lipoxygenase inhibition Melatonin Pineal organ cultures 5 hydroxyicosatetraenoic acid leukotriene leukotriene c4 lipoxygenase melatonin noradrenalin nordihydroguaiaretic acid animal cell cell culture central nervous system drug antagonism drug comparison endocrine system in vitro study nonhuman pineal body rat Acetophenones Animals Arachidonate 5-Lipoxygenase Arachidonate Lipoxygenases Chromones Hydroxyeicosatetraenoic Acids Male Nordihydroguaiaretic Acid Norepinephrine Organ Culture Techniques Pineal Gland Rats Rats, Inbred Strains SRS-A Tetrazoles
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_00283835_v46_n5_p412_Vacas
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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