Radiation protection by cyanide of both rats and mice

MANY investigators have found1-4 that the rat, unlike the mouse, is afforded little or no protection to irradiation damage by the prior administration of cyanide salts. In all their experiments, a limited dose-range of cyanide was tested. The frequently cited results of Dowdy et al.1, for example, w...

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Autores principales: Schubert, J., Markley, J.F.
Formato: JOUR
Lenguaje:English
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Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00280836_v197_n4865_p399_Schubert
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spelling todo:paper_00280836_v197_n4865_p399_Schubert2023-10-03T14:38:29Z Radiation protection by cyanide of both rats and mice Schubert, J. Markley, J.F. cyanide radioprotective agent article CYANIDES RADIATION-PROTECTIVE AGENTS Cyanides Radiation-Protective Agents MANY investigators have found1-4 that the rat, unlike the mouse, is afforded little or no protection to irradiation damage by the prior administration of cyanide salts. In all their experiments, a limited dose-range of cyanide was tested. The frequently cited results of Dowdy et al.1, for example, were obtained using a single dose (3 mg/kg) of sodium cyanide. A recent theory5 states that compounds such as cyanide and azide owe their radiobiological action to the property of stabilization of cuprous (Cu I) ion involved in oxidative processes. The proposal suggests that the dose required to achieve protection would be sharply defined and, if not limited by chemical toxicity of cyanide, it should be possible to demonstrate protection in the rat using the proper dose. Accordingly, survival was compared in rats and mice given a wide range of doses of sodium cyanide prior to X-irradiation. © 1963 Nature Publishing Group. JOUR English info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00280836_v197_n4865_p399_Schubert
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
language English
orig_language_str_mv English
topic cyanide
radioprotective agent
article
CYANIDES
RADIATION-PROTECTIVE AGENTS
Cyanides
Radiation-Protective Agents
spellingShingle cyanide
radioprotective agent
article
CYANIDES
RADIATION-PROTECTIVE AGENTS
Cyanides
Radiation-Protective Agents
Schubert, J.
Markley, J.F.
Radiation protection by cyanide of both rats and mice
topic_facet cyanide
radioprotective agent
article
CYANIDES
RADIATION-PROTECTIVE AGENTS
Cyanides
Radiation-Protective Agents
description MANY investigators have found1-4 that the rat, unlike the mouse, is afforded little or no protection to irradiation damage by the prior administration of cyanide salts. In all their experiments, a limited dose-range of cyanide was tested. The frequently cited results of Dowdy et al.1, for example, were obtained using a single dose (3 mg/kg) of sodium cyanide. A recent theory5 states that compounds such as cyanide and azide owe their radiobiological action to the property of stabilization of cuprous (Cu I) ion involved in oxidative processes. The proposal suggests that the dose required to achieve protection would be sharply defined and, if not limited by chemical toxicity of cyanide, it should be possible to demonstrate protection in the rat using the proper dose. Accordingly, survival was compared in rats and mice given a wide range of doses of sodium cyanide prior to X-irradiation. © 1963 Nature Publishing Group.
format JOUR
author Schubert, J.
Markley, J.F.
author_facet Schubert, J.
Markley, J.F.
author_sort Schubert, J.
title Radiation protection by cyanide of both rats and mice
title_short Radiation protection by cyanide of both rats and mice
title_full Radiation protection by cyanide of both rats and mice
title_fullStr Radiation protection by cyanide of both rats and mice
title_full_unstemmed Radiation protection by cyanide of both rats and mice
title_sort radiation protection by cyanide of both rats and mice
url http://hdl.handle.net/20.500.12110/paper_00280836_v197_n4865_p399_Schubert
work_keys_str_mv AT schubertj radiationprotectionbycyanideofbothratsandmice
AT markleyjf radiationprotectionbycyanideofbothratsandmice
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