Activity-dependent competition regulates motor neuron axon pathfinding via PlexinA3

The role of electrical activity in axon guidance has been extensively studied in vitro. To better understand its role in the intact nervous system, we imaged intracellular Ca2+ in zebrafish primary motor neurons (PMN) during axon pathfinding in vivo. We found that PMN generate specific patterns of C...

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Detalles Bibliográficos
Autores principales: Plazas, P.V., Nicol, X., Spitzer, N.C.
Formato: JOUR
Materias:
inwardly rectifying potassium channel subunit Kir2.1
plexin
plexin A3
unclassified drug
animal cell
animal tissue
article
calcium cell level
developmental stage
electric activity
embryo
gene silencing
in vivo study
motoneuron
nerve fiber
nerve fiber growth
nonhuman
perikaryon
primary motor cortex
priority journal
protein expression
regulatory mechanism
signal transduction
spike
stereotypy
synaptic transmission
zebra fish
Animals
Animals, Genetically Modified
Axons
Calcium Signaling
Gene Knockdown Techniques
Humans
Motor Neurons
Neural Pathways
Potassium Channels, Inwardly Rectifying
Receptors, Cell Surface
Recombinant Proteins
Synaptic Transmission
Zebrafish
Zebrafish Proteins
Danio rerio
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00278424_v110_n4_p1524_Plazas
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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