Modification of the levels of delta-aminolevulinic acid dehydratase in chronic alcoholic patients

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Medical and biochemical analysis were performed on 58 patients with chronic alcoholism. In accordance with medical characterisation, patients were divided in three groups: A (patients having only hepatopathy), B (patients with hepatopathy and neuropathy) and C (patients having only alcoholic neuropa...

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Detalles Bibliográficos
Autores principales: Wider, E.A., Ferranti, D., Mozzarelli, M.N., Giancarlo, H., Della Valle, M.G., Cimmino, V., Movia, R.
Formato: JOUR
Materias:
porphobilinogen synthase
adult
aged
alcoholism
article
female
human
male
metabolism
middle aged
Adult
Aged
Alcoholism
Female
Humans
Male
Middle Aged
Porphobilinogen Synthase
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00257680_v57_n3_p275_Wider
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:Medical and biochemical analysis were performed on 58 patients with chronic alcoholism. In accordance with medical characterisation, patients were divided in three groups: A (patients having only hepatopathy), B (patients with hepatopathy and neuropathy) and C (patients having only alcoholic neuropathy). Simultaneously, several parameters related to heme biosynthesis were examined. Urinary delta-aminolevulic acid (ALA), porphobilinogen (PBG) and porphyrins and fecal porphyrins measurements did not show significant difference among all studied groups. The activities of ALA-dehydratase (ALA-D), uroporphyrinogen-I-synthase (URO-I-S) and uroporphyrinogen-III-synthase (URO-III-S) were monitored in peripheral erythrocytes. From the enzymes measured, only ALA-D levels in groups B and C were significantly depressed (p < 0.002) compared with normal subjects. The decrease in ALA-D correlated with the degree of neuropathy.

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