Modification of the levels of delta-aminolevulinic acid dehydratase in chronic alcoholic patients
Medical and biochemical analysis were performed on 58 patients with chronic alcoholism. In accordance with medical characterisation, patients were divided in three groups: A (patients having only hepatopathy), B (patients with hepatopathy and neuropathy) and C (patients having only alcoholic neuropa...
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_00257680_v57_n3_p275_Wider |
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todo:paper_00257680_v57_n3_p275_Wider2023-10-03T14:36:31Z Modification of the levels of delta-aminolevulinic acid dehydratase in chronic alcoholic patients Wider, E.A. Ferranti, D. Mozzarelli, M.N. Giancarlo, H. Della Valle, M.G. Cimmino, V. Movia, R. porphobilinogen synthase adult aged alcoholism article female human male metabolism middle aged Adult Aged Alcoholism Female Humans Male Middle Aged Porphobilinogen Synthase Medical and biochemical analysis were performed on 58 patients with chronic alcoholism. In accordance with medical characterisation, patients were divided in three groups: A (patients having only hepatopathy), B (patients with hepatopathy and neuropathy) and C (patients having only alcoholic neuropathy). Simultaneously, several parameters related to heme biosynthesis were examined. Urinary delta-aminolevulic acid (ALA), porphobilinogen (PBG) and porphyrins and fecal porphyrins measurements did not show significant difference among all studied groups. The activities of ALA-dehydratase (ALA-D), uroporphyrinogen-I-synthase (URO-I-S) and uroporphyrinogen-III-synthase (URO-III-S) were monitored in peripheral erythrocytes. From the enzymes measured, only ALA-D levels in groups B and C were significantly depressed (p < 0.002) compared with normal subjects. The decrease in ALA-D correlated with the degree of neuropathy. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00257680_v57_n3_p275_Wider |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
porphobilinogen synthase adult aged alcoholism article female human male metabolism middle aged Adult Aged Alcoholism Female Humans Male Middle Aged Porphobilinogen Synthase |
| spellingShingle |
porphobilinogen synthase adult aged alcoholism article female human male metabolism middle aged Adult Aged Alcoholism Female Humans Male Middle Aged Porphobilinogen Synthase Wider, E.A. Ferranti, D. Mozzarelli, M.N. Giancarlo, H. Della Valle, M.G. Cimmino, V. Movia, R. Modification of the levels of delta-aminolevulinic acid dehydratase in chronic alcoholic patients |
| topic_facet |
porphobilinogen synthase adult aged alcoholism article female human male metabolism middle aged Adult Aged Alcoholism Female Humans Male Middle Aged Porphobilinogen Synthase |
| description |
Medical and biochemical analysis were performed on 58 patients with chronic alcoholism. In accordance with medical characterisation, patients were divided in three groups: A (patients having only hepatopathy), B (patients with hepatopathy and neuropathy) and C (patients having only alcoholic neuropathy). Simultaneously, several parameters related to heme biosynthesis were examined. Urinary delta-aminolevulic acid (ALA), porphobilinogen (PBG) and porphyrins and fecal porphyrins measurements did not show significant difference among all studied groups. The activities of ALA-dehydratase (ALA-D), uroporphyrinogen-I-synthase (URO-I-S) and uroporphyrinogen-III-synthase (URO-III-S) were monitored in peripheral erythrocytes. From the enzymes measured, only ALA-D levels in groups B and C were significantly depressed (p < 0.002) compared with normal subjects. The decrease in ALA-D correlated with the degree of neuropathy. |
| format |
JOUR |
| author |
Wider, E.A. Ferranti, D. Mozzarelli, M.N. Giancarlo, H. Della Valle, M.G. Cimmino, V. Movia, R. |
| author_facet |
Wider, E.A. Ferranti, D. Mozzarelli, M.N. Giancarlo, H. Della Valle, M.G. Cimmino, V. Movia, R. |
| author_sort |
Wider, E.A. |
| title |
Modification of the levels of delta-aminolevulinic acid dehydratase in chronic alcoholic patients |
| title_short |
Modification of the levels of delta-aminolevulinic acid dehydratase in chronic alcoholic patients |
| title_full |
Modification of the levels of delta-aminolevulinic acid dehydratase in chronic alcoholic patients |
| title_fullStr |
Modification of the levels of delta-aminolevulinic acid dehydratase in chronic alcoholic patients |
| title_full_unstemmed |
Modification of the levels of delta-aminolevulinic acid dehydratase in chronic alcoholic patients |
| title_sort |
modification of the levels of delta-aminolevulinic acid dehydratase in chronic alcoholic patients |
| url |
http://hdl.handle.net/20.500.12110/paper_00257680_v57_n3_p275_Wider |
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