The existence of two interconvertible forms of 18-hydroxycorticosterone: Is one of them an active pŕecursor of aldosterone?
18-Hydroxycorticosterone exhibits a spontaneous interconversion between two forms separable by paper chromatography, a and b. Upon acetylation, both give rise to at least one compound having identical chromatographic properties irrespective of the basic form utilized. Both forms present different ch...
Guardado en:
| Autores principales: | , |
|---|---|
| Formato: | JOUR |
| Materias: | |
| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_00224731_v6_n1_p69_Damasco |
| Aporte de: |
| id |
todo:paper_00224731_v6_n1_p69_Damasco |
|---|---|
| record_format |
dspace |
| spelling |
todo:paper_00224731_v6_n1_p69_Damasco2023-10-03T14:33:11Z The existence of two interconvertible forms of 18-hydroxycorticosterone: Is one of them an active pŕecursor of aldosterone? Damasco, M.C. Lantos, C.P. 18 hydroxycorticosterone aldosterone hydroxycorticosteroid radioisotope steroid hormone 18 hydroxyprogesterone adrenal gland aldosterone c 14 corticosterone h 3 drug absorption drug metabolism formyl synthetase paper chromatography pharmacokinetics rat theoretical study 18-Hydroxycorticosterone Acetylation Adrenal Glands Aldosterone Animal Carbon Radioisotopes Chromatography, Gel Chromatography, Paper Corticosterone Male Rats Solvents Time Factors Tritium 18-Hydroxycorticosterone exhibits a spontaneous interconversion between two forms separable by paper chromatography, a and b. Upon acetylation, both give rise to at least one compound having identical chromatographic properties irrespective of the basic form utilized. Both forms present different chromatographic patterns upon elution from Sephadex LH 20. The less polar on paper strips (a) also migrated closer to the solvent front after gel filtration. In repeated experiments, a proved to be a better precursor for aldosterone-like material than b. In at least one case, these results could be confirmed for purified aldosterone. Also, the uptake of a by adrenal tissue is higher than that of b. © 1975. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00224731_v6_n1_p69_Damasco |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
18 hydroxycorticosterone aldosterone hydroxycorticosteroid radioisotope steroid hormone 18 hydroxyprogesterone adrenal gland aldosterone c 14 corticosterone h 3 drug absorption drug metabolism formyl synthetase paper chromatography pharmacokinetics rat theoretical study 18-Hydroxycorticosterone Acetylation Adrenal Glands Aldosterone Animal Carbon Radioisotopes Chromatography, Gel Chromatography, Paper Corticosterone Male Rats Solvents Time Factors Tritium |
| spellingShingle |
18 hydroxycorticosterone aldosterone hydroxycorticosteroid radioisotope steroid hormone 18 hydroxyprogesterone adrenal gland aldosterone c 14 corticosterone h 3 drug absorption drug metabolism formyl synthetase paper chromatography pharmacokinetics rat theoretical study 18-Hydroxycorticosterone Acetylation Adrenal Glands Aldosterone Animal Carbon Radioisotopes Chromatography, Gel Chromatography, Paper Corticosterone Male Rats Solvents Time Factors Tritium Damasco, M.C. Lantos, C.P. The existence of two interconvertible forms of 18-hydroxycorticosterone: Is one of them an active pŕecursor of aldosterone? |
| topic_facet |
18 hydroxycorticosterone aldosterone hydroxycorticosteroid radioisotope steroid hormone 18 hydroxyprogesterone adrenal gland aldosterone c 14 corticosterone h 3 drug absorption drug metabolism formyl synthetase paper chromatography pharmacokinetics rat theoretical study 18-Hydroxycorticosterone Acetylation Adrenal Glands Aldosterone Animal Carbon Radioisotopes Chromatography, Gel Chromatography, Paper Corticosterone Male Rats Solvents Time Factors Tritium |
| description |
18-Hydroxycorticosterone exhibits a spontaneous interconversion between two forms separable by paper chromatography, a and b. Upon acetylation, both give rise to at least one compound having identical chromatographic properties irrespective of the basic form utilized. Both forms present different chromatographic patterns upon elution from Sephadex LH 20. The less polar on paper strips (a) also migrated closer to the solvent front after gel filtration. In repeated experiments, a proved to be a better precursor for aldosterone-like material than b. In at least one case, these results could be confirmed for purified aldosterone. Also, the uptake of a by adrenal tissue is higher than that of b. © 1975. |
| format |
JOUR |
| author |
Damasco, M.C. Lantos, C.P. |
| author_facet |
Damasco, M.C. Lantos, C.P. |
| author_sort |
Damasco, M.C. |
| title |
The existence of two interconvertible forms of 18-hydroxycorticosterone: Is one of them an active pŕecursor of aldosterone? |
| title_short |
The existence of two interconvertible forms of 18-hydroxycorticosterone: Is one of them an active pŕecursor of aldosterone? |
| title_full |
The existence of two interconvertible forms of 18-hydroxycorticosterone: Is one of them an active pŕecursor of aldosterone? |
| title_fullStr |
The existence of two interconvertible forms of 18-hydroxycorticosterone: Is one of them an active pŕecursor of aldosterone? |
| title_full_unstemmed |
The existence of two interconvertible forms of 18-hydroxycorticosterone: Is one of them an active pŕecursor of aldosterone? |
| title_sort |
existence of two interconvertible forms of 18-hydroxycorticosterone: is one of them an active pŕecursor of aldosterone? |
| url |
http://hdl.handle.net/20.500.12110/paper_00224731_v6_n1_p69_Damasco |
| work_keys_str_mv |
AT damascomc theexistenceoftwointerconvertibleformsof18hydroxycorticosteroneisoneofthemanactiveprecursorofaldosterone AT lantoscp theexistenceoftwointerconvertibleformsof18hydroxycorticosteroneisoneofthemanactiveprecursorofaldosterone AT damascomc existenceoftwointerconvertibleformsof18hydroxycorticosteroneisoneofthemanactiveprecursorofaldosterone AT lantoscp existenceoftwointerconvertibleformsof18hydroxycorticosteroneisoneofthemanactiveprecursorofaldosterone |
| _version_ |
1807322515188482048 |