Metabolism of [3H]-testosterone by the adranal of the dog: The action of acth

The metabolism of [3H]-testosterone in perfused dog adrenals and in adrenal minces of a normal dog has been studied. Three principal metabolites were studied and identified by isotope dilution and gas-liquid chromatography-mass speetrometry: androstenedione, 11β-hydroxyandrostenedione and 11 β-hydro...

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Detalles Bibliográficos
Autores principales: Wassermann, G.F., Baldi, A., del Castillo, E., Charreau, E.
Formato: JOUR
Materias:
androstane derivative
androstenedione
corticosteroid
corticotropin
hydroxysteroid
oxosteroid
testosterone
tritium
adrenal gland
animal
article
biosynthesis
blood
crystallization
dog
drug effect
gas chromatography
hypophysectomy
hypophysis
in vitro study
male
mass spectrometry
metabolism
perfusion
physiology
thin layer chromatography
Adrenal Cortex Hormones
Adrenal Glands
Androstenedione
Androstenes
Animal
Chromatography, Gas
Chromatography, Thin Layer
Corticotropin
Crystallization
Dogs
Hydroxysteroids
Hypophysectomy
In Vitro
Ketosteroids
Male
Perfusion
Pituitary Gland
Spectrum Analysis, Mass
Testosterone
Tritium
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00224731_v4_n2_p217_Wassermann
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:The metabolism of [3H]-testosterone in perfused dog adrenals and in adrenal minces of a normal dog has been studied. Three principal metabolites were studied and identified by isotope dilution and gas-liquid chromatography-mass speetrometry: androstenedione, 11β-hydroxyandrostenedione and 11 β-hydroxytestosterone. The last of these metabolites is obtained in high yield which is further increased after ACTH administration. © 1973.

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