Biosynthesis of bufadienolides in toads. III-Experiments with [2-14C]mevalonic acid, [20-14C]3β-hydroxy-5-pregnen-20-one and [20-14C]cholesterol

The biosynthesis of bufadienolides in Bufo paracnemis toads has been studied in different seasons of the year using [2-14C]mevalonic acid, [20-14C]pregnenolone, and [20-14C]cholesterol as precursors. The results showed that the doubly unsaturated δ-lactone ring of the bufadieno-lides is directly der...

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Autores principales:	Porto, A.M., Baralle, F.E., Gros, E.G.
Formato:	JOUR
Materias:	bufadienolide derivative carbon cholesterol mevalonic acid pregnenolone venom animal article biosynthesis gallbladder metabolism season toad Animal Bufanolides Bufonidae Carbon Isotopes Cholesterol Gallbladder Mevalonic Acid Pregnenolone Seasons Venoms
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_00224731_v3_n1_p11_Porto
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_00224731_v3_n1_p11_Porto
record_format	dspace
spelling	todo:paper_00224731_v3_n1_p11_Porto2023-10-03T14:33:08Z Biosynthesis of bufadienolides in toads. III-Experiments with [2-14C]mevalonic acid, [20-14C]3β-hydroxy-5-pregnen-20-one and [20-14C]cholesterol Porto, A.M. Baralle, F.E. Gros, E.G. bufadienolide derivative carbon cholesterol mevalonic acid pregnenolone venom animal article biosynthesis gallbladder metabolism season toad Animal Bufanolides Bufonidae Carbon Isotopes Cholesterol Gallbladder Mevalonic Acid Pregnenolone Seasons Venoms The biosynthesis of bufadienolides in Bufo paracnemis toads has been studied in different seasons of the year using [2-14C]mevalonic acid, [20-14C]pregnenolone, and [20-14C]cholesterol as precursors. The results showed that the doubly unsaturated δ-lactone ring of the bufadieno-lides is directly derived from the cholesterol side chain without the compound's prior conversion into pregnenolone. The probable sequence in which the different bufadienolides are formed is discussed. © 1972. Fil:Porto, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Baralle, F.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Gros, E.G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00224731_v3_n1_p11_Porto
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	bufadienolide derivative carbon cholesterol mevalonic acid pregnenolone venom animal article biosynthesis gallbladder metabolism season toad Animal Bufanolides Bufonidae Carbon Isotopes Cholesterol Gallbladder Mevalonic Acid Pregnenolone Seasons Venoms
spellingShingle	bufadienolide derivative carbon cholesterol mevalonic acid pregnenolone venom animal article biosynthesis gallbladder metabolism season toad Animal Bufanolides Bufonidae Carbon Isotopes Cholesterol Gallbladder Mevalonic Acid Pregnenolone Seasons Venoms Porto, A.M. Baralle, F.E. Gros, E.G. Biosynthesis of bufadienolides in toads. III-Experiments with [2-14C]mevalonic acid, [20-14C]3β-hydroxy-5-pregnen-20-one and [20-14C]cholesterol
topic_facet	bufadienolide derivative carbon cholesterol mevalonic acid pregnenolone venom animal article biosynthesis gallbladder metabolism season toad Animal Bufanolides Bufonidae Carbon Isotopes Cholesterol Gallbladder Mevalonic Acid Pregnenolone Seasons Venoms
description	The biosynthesis of bufadienolides in Bufo paracnemis toads has been studied in different seasons of the year using [2-14C]mevalonic acid, [20-14C]pregnenolone, and [20-14C]cholesterol as precursors. The results showed that the doubly unsaturated δ-lactone ring of the bufadieno-lides is directly derived from the cholesterol side chain without the compound's prior conversion into pregnenolone. The probable sequence in which the different bufadienolides are formed is discussed. © 1972.
format	JOUR
author	Porto, A.M. Baralle, F.E. Gros, E.G.
author_facet	Porto, A.M. Baralle, F.E. Gros, E.G.
author_sort	Porto, A.M.
title	Biosynthesis of bufadienolides in toads. III-Experiments with [2-14C]mevalonic acid, [20-14C]3β-hydroxy-5-pregnen-20-one and [20-14C]cholesterol
title_short	Biosynthesis of bufadienolides in toads. III-Experiments with [2-14C]mevalonic acid, [20-14C]3β-hydroxy-5-pregnen-20-one and [20-14C]cholesterol
title_full	Biosynthesis of bufadienolides in toads. III-Experiments with [2-14C]mevalonic acid, [20-14C]3β-hydroxy-5-pregnen-20-one and [20-14C]cholesterol
title_fullStr	Biosynthesis of bufadienolides in toads. III-Experiments with [2-14C]mevalonic acid, [20-14C]3β-hydroxy-5-pregnen-20-one and [20-14C]cholesterol
title_full_unstemmed	Biosynthesis of bufadienolides in toads. III-Experiments with [2-14C]mevalonic acid, [20-14C]3β-hydroxy-5-pregnen-20-one and [20-14C]cholesterol
title_sort	biosynthesis of bufadienolides in toads. iii-experiments with [2-14c]mevalonic acid, [20-14c]3β-hydroxy-5-pregnen-20-one and [20-14c]cholesterol
url	http://hdl.handle.net/20.500.12110/paper_00224731_v3_n1_p11_Porto
work_keys_str_mv	AT portoam biosynthesisofbufadienolidesintoadsiiiexperimentswith214cmevalonicacid2014c3bhydroxy5pregnen20oneand2014ccholesterol AT barallefe biosynthesisofbufadienolidesintoadsiiiexperimentswith214cmevalonicacid2014c3bhydroxy5pregnen20oneand2014ccholesterol AT groseg biosynthesisofbufadienolidesintoadsiiiexperimentswith214cmevalonicacid2014c3bhydroxy5pregnen20oneand2014ccholesterol
_version_	1782025586654314496

Biosynthesis of bufadienolides in toads. III-Experiments with [2-14C]mevalonic acid, [20-14C]3β-hydroxy-5-pregnen-20-one and [20-14C]cholesterol

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