Effects of ACTH on the last step of aldosterone biosynthesis

The production of tritiated aldosterone and tritiated SM (a saponifiable 18-hydroxycorticosterone derivative) by rat adrenals were studied at various incubation times in absence or presence of two concentrations of ACTH. Tritiated 18-hydroxycorticosterone or 18-deoxyaldosterone served as precursors....

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Autores principales: Cozza, E.N., Ceballos, N.R., Lantos, C.P.
Formato: JOUR
Materias:
18 hydroxycorticosterone
aldosterone
corticotropin
radioisotope
adrenal gland
animal cell
article
nonhuman
priority journal
rat
Adrenal Glands
Aldosterone
Animal
Corticotropin
Male
Mitochondria
Rats
Support, Non-U.S. Gov't
Animalia
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00224731_v33_n6_p1253_Cozza
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_00224731_v33_n6_p1253_Cozza
record_format dspace
spelling todo:paper_00224731_v33_n6_p1253_Cozza2023-10-03T14:33:08Z Effects of ACTH on the last step of aldosterone biosynthesis Cozza, E.N. Ceballos, N.R. Lantos, C.P. 18 hydroxycorticosterone aldosterone corticotropin radioisotope adrenal gland animal cell article nonhuman priority journal rat Adrenal Glands Aldosterone Animal Corticotropin Male Mitochondria Rats Support, Non-U.S. Gov't Animalia The production of tritiated aldosterone and tritiated SM (a saponifiable 18-hydroxycorticosterone derivative) by rat adrenals were studied at various incubation times in absence or presence of two concentrations of ACTH. Tritiated 18-hydroxycorticosterone or 18-deoxyaldosterone served as precursors. The lower ACTH concentration (150 pM) increased the production of tritiated aldosterone. Whereas, the higher ACTH concentration (1.5 μM) stimulated tritiated aldosterone production at shorter incubation time (30 min), while after 60 min it inhibited. This time dependency would reflect variations in the levels of endogenous steroids. On the other hand, the effects of ACTH on tritiated SM production were opposite to those on tritiated aldosterone. In effect, while 150 pM ACTH inhibited SM production, 1.5 μM ACTH stimulated it. These results suggest that ACTH promotes opposite effects on the productions of aldosterone and SM and therefore both productions would be coordinated under the regulation of ACTH. © 1989. Fil:Cozza, E.N. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Ceballos, N.R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00224731_v33_n6_p1253_Cozza
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic 18 hydroxycorticosterone
aldosterone
corticotropin
radioisotope
adrenal gland
animal cell
article
nonhuman
priority journal
rat
Adrenal Glands
Aldosterone
Animal
Corticotropin
Male
Mitochondria
Rats
Support, Non-U.S. Gov't
Animalia
spellingShingle 18 hydroxycorticosterone
aldosterone
corticotropin
radioisotope
adrenal gland
animal cell
article
nonhuman
priority journal
rat
Adrenal Glands
Aldosterone
Animal
Corticotropin
Male
Mitochondria
Rats
Support, Non-U.S. Gov't
Animalia
Cozza, E.N.
Ceballos, N.R.
Lantos, C.P.
Effects of ACTH on the last step of aldosterone biosynthesis
topic_facet 18 hydroxycorticosterone
aldosterone
corticotropin
radioisotope
adrenal gland
animal cell
article
nonhuman
priority journal
rat
Adrenal Glands
Aldosterone
Animal
Corticotropin
Male
Mitochondria
Rats
Support, Non-U.S. Gov't
Animalia
description The production of tritiated aldosterone and tritiated SM (a saponifiable 18-hydroxycorticosterone derivative) by rat adrenals were studied at various incubation times in absence or presence of two concentrations of ACTH. Tritiated 18-hydroxycorticosterone or 18-deoxyaldosterone served as precursors. The lower ACTH concentration (150 pM) increased the production of tritiated aldosterone. Whereas, the higher ACTH concentration (1.5 μM) stimulated tritiated aldosterone production at shorter incubation time (30 min), while after 60 min it inhibited. This time dependency would reflect variations in the levels of endogenous steroids. On the other hand, the effects of ACTH on tritiated SM production were opposite to those on tritiated aldosterone. In effect, while 150 pM ACTH inhibited SM production, 1.5 μM ACTH stimulated it. These results suggest that ACTH promotes opposite effects on the productions of aldosterone and SM and therefore both productions would be coordinated under the regulation of ACTH. © 1989.
format JOUR
author Cozza, E.N.
Ceballos, N.R.
Lantos, C.P.
author_facet Cozza, E.N.
Ceballos, N.R.
Lantos, C.P.
author_sort Cozza, E.N.
title Effects of ACTH on the last step of aldosterone biosynthesis
title_short Effects of ACTH on the last step of aldosterone biosynthesis
title_full Effects of ACTH on the last step of aldosterone biosynthesis
title_fullStr Effects of ACTH on the last step of aldosterone biosynthesis
title_full_unstemmed Effects of ACTH on the last step of aldosterone biosynthesis
title_sort effects of acth on the last step of aldosterone biosynthesis
url http://hdl.handle.net/20.500.12110/paper_00224731_v33_n6_p1253_Cozza
work_keys_str_mv AT cozzaen effectsofacthonthelaststepofaldosteronebiosynthesis
AT ceballosnr effectsofacthonthelaststepofaldosteronebiosynthesis
AT lantoscp effectsofacthonthelaststepofaldosteronebiosynthesis
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