In vivo secretion of 3α-hydroxy-5α-pregnan-20-one, a potent anaesthetic steroid, by the adrenal gland of the rat

3αOH-5α-Pregnan-20-one (allo-THP), a steroid with strong anaesthetic properties, was found to be secreted by the adrenal gland of the rat in quantities similar to those secreted by the rat ovary. From the hypnotic potencies established for this and other endogenous steroids there can be little doubt...

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Autores principales: Holzbauer, M., Birmingham, M.K., de Nicola, A.F., Oliver, J.T.
Formato: JOUR
Materias:
3alpha hydroxy 5alpha pregnan 20 one
pregnenolone
progesterone
adrenal gland
animal experiment
drug analysis
drug blood level
drug determination
drug metabolism
endocrine system
nonhuman
priority journal
rat
steroid anesthesia
Adrenal Glands
Animal
Comparative Study
Desoxycorticosterone
Female
Kinetics
Pregnanes
Pregnanolone
Pregnenolone
Progesterone
Rats
Rats, Inbred Strains
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00224731_v22_n1_p97_Holzbauer
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_00224731_v22_n1_p97_Holzbauer
record_format dspace
spelling todo:paper_00224731_v22_n1_p97_Holzbauer2023-10-03T14:33:04Z In vivo secretion of 3α-hydroxy-5α-pregnan-20-one, a potent anaesthetic steroid, by the adrenal gland of the rat Holzbauer, M. Birmingham, M.K. de Nicola, A.F. Oliver, J.T. 3alpha hydroxy 5alpha pregnan 20 one pregnenolone progesterone adrenal gland animal experiment drug analysis drug blood level drug determination drug metabolism endocrine system nonhuman priority journal rat steroid anesthesia Adrenal Glands Animal Comparative Study Desoxycorticosterone Female Kinetics Pregnanes Pregnanolone Pregnenolone Progesterone Rats Rats, Inbred Strains 3αOH-5α-Pregnan-20-one (allo-THP), a steroid with strong anaesthetic properties, was found to be secreted by the adrenal gland of the rat in quantities similar to those secreted by the rat ovary. From the hypnotic potencies established for this and other endogenous steroids there can be little doubt that the total amount of steroids with anaesthetic properties produced in a female rat are sufficient to exert a depressant action on certain cells of the brain. In rats with intact adrenal glands a positive correlation existed between the adrenal secretion of allo-THP and pregnenolone or progesterone, whereas that between allo-THP and DOC was negative. This could be the result of a competition between the enzymes responsible for the oxidation and reduction of progesterone, the common precursor of allo-THP and DOC. The possibility that allo-THP could have hypotensive actions was suggested. © 1985. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00224731_v22_n1_p97_Holzbauer
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic 3alpha hydroxy 5alpha pregnan 20 one
pregnenolone
progesterone
adrenal gland
animal experiment
drug analysis
drug blood level
drug determination
drug metabolism
endocrine system
nonhuman
priority journal
rat
steroid anesthesia
Adrenal Glands
Animal
Comparative Study
Desoxycorticosterone
Female
Kinetics
Pregnanes
Pregnanolone
Pregnenolone
Progesterone
Rats
Rats, Inbred Strains
spellingShingle 3alpha hydroxy 5alpha pregnan 20 one
pregnenolone
progesterone
adrenal gland
animal experiment
drug analysis
drug blood level
drug determination
drug metabolism
endocrine system
nonhuman
priority journal
rat
steroid anesthesia
Adrenal Glands
Animal
Comparative Study
Desoxycorticosterone
Female
Kinetics
Pregnanes
Pregnanolone
Pregnenolone
Progesterone
Rats
Rats, Inbred Strains
Holzbauer, M.
Birmingham, M.K.
de Nicola, A.F.
Oliver, J.T.
In vivo secretion of 3α-hydroxy-5α-pregnan-20-one, a potent anaesthetic steroid, by the adrenal gland of the rat
topic_facet 3alpha hydroxy 5alpha pregnan 20 one
pregnenolone
progesterone
adrenal gland
animal experiment
drug analysis
drug blood level
drug determination
drug metabolism
endocrine system
nonhuman
priority journal
rat
steroid anesthesia
Adrenal Glands
Animal
Comparative Study
Desoxycorticosterone
Female
Kinetics
Pregnanes
Pregnanolone
Pregnenolone
Progesterone
Rats
Rats, Inbred Strains
description 3αOH-5α-Pregnan-20-one (allo-THP), a steroid with strong anaesthetic properties, was found to be secreted by the adrenal gland of the rat in quantities similar to those secreted by the rat ovary. From the hypnotic potencies established for this and other endogenous steroids there can be little doubt that the total amount of steroids with anaesthetic properties produced in a female rat are sufficient to exert a depressant action on certain cells of the brain. In rats with intact adrenal glands a positive correlation existed between the adrenal secretion of allo-THP and pregnenolone or progesterone, whereas that between allo-THP and DOC was negative. This could be the result of a competition between the enzymes responsible for the oxidation and reduction of progesterone, the common precursor of allo-THP and DOC. The possibility that allo-THP could have hypotensive actions was suggested. © 1985.
format JOUR
author Holzbauer, M.
Birmingham, M.K.
de Nicola, A.F.
Oliver, J.T.
author_facet Holzbauer, M.
Birmingham, M.K.
de Nicola, A.F.
Oliver, J.T.
author_sort Holzbauer, M.
title In vivo secretion of 3α-hydroxy-5α-pregnan-20-one, a potent anaesthetic steroid, by the adrenal gland of the rat
title_short In vivo secretion of 3α-hydroxy-5α-pregnan-20-one, a potent anaesthetic steroid, by the adrenal gland of the rat
title_full In vivo secretion of 3α-hydroxy-5α-pregnan-20-one, a potent anaesthetic steroid, by the adrenal gland of the rat
title_fullStr In vivo secretion of 3α-hydroxy-5α-pregnan-20-one, a potent anaesthetic steroid, by the adrenal gland of the rat
title_full_unstemmed In vivo secretion of 3α-hydroxy-5α-pregnan-20-one, a potent anaesthetic steroid, by the adrenal gland of the rat
title_sort in vivo secretion of 3α-hydroxy-5α-pregnan-20-one, a potent anaesthetic steroid, by the adrenal gland of the rat
url http://hdl.handle.net/20.500.12110/paper_00224731_v22_n1_p97_Holzbauer
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