Role of receptors for epidermal growth factor and insulin-like growth factors I and II in the differentiation of rat mammary glands from lactogenesis I to lactogenesis II

In addition to ovarian steroids and lactogenic hormones from the placenta and pituitary, growth factors control the growth and differentiation of mammary glands. Lactogenesis II at the end of pregnancy is under the control of progesterone. Ovariectomy results in a significant decrease in the number...

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Autores principales: Bussmann, L.E., Bussmann, I.M., Charreau, E.H.
Formato: JOUR
Materias:
epidermal growth factor receptor
estradiol
progesterone
somatomedin B receptor
somatomedin C receptor
steroid
animal experiment
article
differentiation
female
hormonal regulation
hormone substitution
mammary gland
milk production
nonhuman
ovariectomy
priority journal
rat
Animalia
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00224251_v107_n2_p307_Bussmann
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_00224251_v107_n2_p307_Bussmann
record_format dspace
spelling todo:paper_00224251_v107_n2_p307_Bussmann2023-10-03T14:32:52Z Role of receptors for epidermal growth factor and insulin-like growth factors I and II in the differentiation of rat mammary glands from lactogenesis I to lactogenesis II Bussmann, L.E. Bussmann, I.M. Charreau, E.H. epidermal growth factor receptor estradiol progesterone somatomedin B receptor somatomedin C receptor steroid animal experiment article differentiation female hormonal regulation hormone substitution mammary gland milk production nonhuman ovariectomy priority journal rat Animalia In addition to ovarian steroids and lactogenic hormones from the placenta and pituitary, growth factors control the growth and differentiation of mammary glands. Lactogenesis II at the end of pregnancy is under the control of progesterone. Ovariectomy results in a significant decrease in the number of receptors for epidermal growth factor (EGF) and insulin-like growth factor I (IGF-I) and an increase in IGF-II binding sites in mammary gland acini of rats, without affecting the affinity for their respective ligand. Although concentrations of EGF, IGF-I and IGF-II receptors are regulated by oestradiol and progesterone, replacement treatment with ovarian steroids after ovariectomy showed that receptor concentrations do not mediate the restraint on lactogenesis. Progesterone treatment, which inhibits the onset of lactogenesis II, did not restore EGF receptor concentrations to control values, and the presence of oestradiol was required to reverse the effect of ovariectomy. Oestradiol, which potentiates the effect of ovariectomy on milk synthesis, increases IGF-I receptor concentrations. IGF-II receptor concentrations, after the different steroid treatments, were consistent with the steroid effect on milk synthesis. The changes observed in the concentrations of these growth factor receptors at the onset of mammary gland secretion are not considered to affect the progesterone block to lactogenesis II, but rather are a consequence of the shift of the hormonal and, hence, physiological status of the gland. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00224251_v107_n2_p307_Bussmann
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic epidermal growth factor receptor
estradiol
progesterone
somatomedin B receptor
somatomedin C receptor
steroid
animal experiment
article
differentiation
female
hormonal regulation
hormone substitution
mammary gland
milk production
nonhuman
ovariectomy
priority journal
rat
Animalia
spellingShingle epidermal growth factor receptor
estradiol
progesterone
somatomedin B receptor
somatomedin C receptor
steroid
animal experiment
article
differentiation
female
hormonal regulation
hormone substitution
mammary gland
milk production
nonhuman
ovariectomy
priority journal
rat
Animalia
Bussmann, L.E.
Bussmann, I.M.
Charreau, E.H.
Role of receptors for epidermal growth factor and insulin-like growth factors I and II in the differentiation of rat mammary glands from lactogenesis I to lactogenesis II
topic_facet epidermal growth factor receptor
estradiol
progesterone
somatomedin B receptor
somatomedin C receptor
steroid
animal experiment
article
differentiation
female
hormonal regulation
hormone substitution
mammary gland
milk production
nonhuman
ovariectomy
priority journal
rat
Animalia
description In addition to ovarian steroids and lactogenic hormones from the placenta and pituitary, growth factors control the growth and differentiation of mammary glands. Lactogenesis II at the end of pregnancy is under the control of progesterone. Ovariectomy results in a significant decrease in the number of receptors for epidermal growth factor (EGF) and insulin-like growth factor I (IGF-I) and an increase in IGF-II binding sites in mammary gland acini of rats, without affecting the affinity for their respective ligand. Although concentrations of EGF, IGF-I and IGF-II receptors are regulated by oestradiol and progesterone, replacement treatment with ovarian steroids after ovariectomy showed that receptor concentrations do not mediate the restraint on lactogenesis. Progesterone treatment, which inhibits the onset of lactogenesis II, did not restore EGF receptor concentrations to control values, and the presence of oestradiol was required to reverse the effect of ovariectomy. Oestradiol, which potentiates the effect of ovariectomy on milk synthesis, increases IGF-I receptor concentrations. IGF-II receptor concentrations, after the different steroid treatments, were consistent with the steroid effect on milk synthesis. The changes observed in the concentrations of these growth factor receptors at the onset of mammary gland secretion are not considered to affect the progesterone block to lactogenesis II, but rather are a consequence of the shift of the hormonal and, hence, physiological status of the gland.
format JOUR
author Bussmann, L.E.
Bussmann, I.M.
Charreau, E.H.
author_facet Bussmann, L.E.
Bussmann, I.M.
Charreau, E.H.
author_sort Bussmann, L.E.
title Role of receptors for epidermal growth factor and insulin-like growth factors I and II in the differentiation of rat mammary glands from lactogenesis I to lactogenesis II
title_short Role of receptors for epidermal growth factor and insulin-like growth factors I and II in the differentiation of rat mammary glands from lactogenesis I to lactogenesis II
title_full Role of receptors for epidermal growth factor and insulin-like growth factors I and II in the differentiation of rat mammary glands from lactogenesis I to lactogenesis II
title_fullStr Role of receptors for epidermal growth factor and insulin-like growth factors I and II in the differentiation of rat mammary glands from lactogenesis I to lactogenesis II
title_full_unstemmed Role of receptors for epidermal growth factor and insulin-like growth factors I and II in the differentiation of rat mammary glands from lactogenesis I to lactogenesis II
title_sort role of receptors for epidermal growth factor and insulin-like growth factors i and ii in the differentiation of rat mammary glands from lactogenesis i to lactogenesis ii
url http://hdl.handle.net/20.500.12110/paper_00224251_v107_n2_p307_Bussmann
work_keys_str_mv AT bussmannle roleofreceptorsforepidermalgrowthfactorandinsulinlikegrowthfactorsiandiiinthedifferentiationofratmammaryglandsfromlactogenesisitolactogenesisii
AT bussmannim roleofreceptorsforepidermalgrowthfactorandinsulinlikegrowthfactorsiandiiinthedifferentiationofratmammaryglandsfromlactogenesisitolactogenesisii
AT charreaueh roleofreceptorsforepidermalgrowthfactorandinsulinlikegrowthfactorsiandiiinthedifferentiationofratmammaryglandsfromlactogenesisitolactogenesisii
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