Chronic pregabalin treatment decreases excitability of dentate gyrus and accelerates maturation of adult-born granule cells
Pregabalin (PGB) is extensively prescribed to treat neurological and neuropsychiatrical conditions such as neuropathic pain, anxiety disorders, and epilepsy. Although PGB is known to bind selectively to the α2δ subunit of voltage-gated calcium channels, there is little understanding about how it exe...
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todo:paper_00223042_v140_n2_p257_Lempel2023-10-03T14:30:51Z Chronic pregabalin treatment decreases excitability of dentate gyrus and accelerates maturation of adult-born granule cells Lempel, A.A. Coll, L. Schinder, A.F. Uchitel, O.D. Piriz, J. dentate gyrus Gabapentin neurogenesis Pregabalin pregabalin retrovirus vector 4 aminobutyric acid calcium channel pregabalin adult animal cell animal experiment animal tissue Article brain electrophysiology brain function cell maturation controlled study dentate hilus drug mechanism ex vivo study excitatory postsynaptic potential granule cell in vivo study male mouse nerve cell excitability nerve cell plasticity neuroanatomy neuromodulation newborn nonhuman priority journal synaptic transmission whole cell patch clamp aging animal C57BL mouse cell granule dentate gyrus drug effects epilepsy metabolism nerve cell neuralgia physiology Aging Animals Calcium Channels Cytoplasmic Granules Dentate Gyrus Epilepsy gamma-Aminobutyric Acid Mice, Inbred C57BL Neuralgia Neurons Pregabalin Pregabalin (PGB) is extensively prescribed to treat neurological and neuropsychiatrical conditions such as neuropathic pain, anxiety disorders, and epilepsy. Although PGB is known to bind selectively to the α2δ subunit of voltage-gated calcium channels, there is little understanding about how it exerts its therapeutic effects. In this article, we analyzed the effects of an in vivo chronic treatment with PGB over the physiology of dentate gyrus granule cells (DGGCs) using ex vivo electrophysiological and morphological analysis in adult mice. We found that PGB decreases neuronal excitability of DGGCs. In addition, PGB accelerates maturation of adult-born DGGCs, an effect that would modify dentate gyrus plasticity. Together, these findings suggest that PGB reduces activity in the dentate gyrus and modulates overall network plasticity, which might contribute to its therapeutic effects. (Figure presented.). Cover Image for this issue: doi: 10.1111/jnc.13783. © 2016 International Society for Neurochemistry JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00223042_v140_n2_p257_Lempel |
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Universidad de Buenos Aires |
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I-28 |
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R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
dentate gyrus Gabapentin neurogenesis Pregabalin pregabalin retrovirus vector 4 aminobutyric acid calcium channel pregabalin adult animal cell animal experiment animal tissue Article brain electrophysiology brain function cell maturation controlled study dentate hilus drug mechanism ex vivo study excitatory postsynaptic potential granule cell in vivo study male mouse nerve cell excitability nerve cell plasticity neuroanatomy neuromodulation newborn nonhuman priority journal synaptic transmission whole cell patch clamp aging animal C57BL mouse cell granule dentate gyrus drug effects epilepsy metabolism nerve cell neuralgia physiology Aging Animals Calcium Channels Cytoplasmic Granules Dentate Gyrus Epilepsy gamma-Aminobutyric Acid Mice, Inbred C57BL Neuralgia Neurons Pregabalin |
| spellingShingle |
dentate gyrus Gabapentin neurogenesis Pregabalin pregabalin retrovirus vector 4 aminobutyric acid calcium channel pregabalin adult animal cell animal experiment animal tissue Article brain electrophysiology brain function cell maturation controlled study dentate hilus drug mechanism ex vivo study excitatory postsynaptic potential granule cell in vivo study male mouse nerve cell excitability nerve cell plasticity neuroanatomy neuromodulation newborn nonhuman priority journal synaptic transmission whole cell patch clamp aging animal C57BL mouse cell granule dentate gyrus drug effects epilepsy metabolism nerve cell neuralgia physiology Aging Animals Calcium Channels Cytoplasmic Granules Dentate Gyrus Epilepsy gamma-Aminobutyric Acid Mice, Inbred C57BL Neuralgia Neurons Pregabalin Lempel, A.A. Coll, L. Schinder, A.F. Uchitel, O.D. Piriz, J. Chronic pregabalin treatment decreases excitability of dentate gyrus and accelerates maturation of adult-born granule cells |
| topic_facet |
dentate gyrus Gabapentin neurogenesis Pregabalin pregabalin retrovirus vector 4 aminobutyric acid calcium channel pregabalin adult animal cell animal experiment animal tissue Article brain electrophysiology brain function cell maturation controlled study dentate hilus drug mechanism ex vivo study excitatory postsynaptic potential granule cell in vivo study male mouse nerve cell excitability nerve cell plasticity neuroanatomy neuromodulation newborn nonhuman priority journal synaptic transmission whole cell patch clamp aging animal C57BL mouse cell granule dentate gyrus drug effects epilepsy metabolism nerve cell neuralgia physiology Aging Animals Calcium Channels Cytoplasmic Granules Dentate Gyrus Epilepsy gamma-Aminobutyric Acid Mice, Inbred C57BL Neuralgia Neurons Pregabalin |
| description |
Pregabalin (PGB) is extensively prescribed to treat neurological and neuropsychiatrical conditions such as neuropathic pain, anxiety disorders, and epilepsy. Although PGB is known to bind selectively to the α2δ subunit of voltage-gated calcium channels, there is little understanding about how it exerts its therapeutic effects. In this article, we analyzed the effects of an in vivo chronic treatment with PGB over the physiology of dentate gyrus granule cells (DGGCs) using ex vivo electrophysiological and morphological analysis in adult mice. We found that PGB decreases neuronal excitability of DGGCs. In addition, PGB accelerates maturation of adult-born DGGCs, an effect that would modify dentate gyrus plasticity. Together, these findings suggest that PGB reduces activity in the dentate gyrus and modulates overall network plasticity, which might contribute to its therapeutic effects. (Figure presented.). Cover Image for this issue: doi: 10.1111/jnc.13783. © 2016 International Society for Neurochemistry |
| format |
JOUR |
| author |
Lempel, A.A. Coll, L. Schinder, A.F. Uchitel, O.D. Piriz, J. |
| author_facet |
Lempel, A.A. Coll, L. Schinder, A.F. Uchitel, O.D. Piriz, J. |
| author_sort |
Lempel, A.A. |
| title |
Chronic pregabalin treatment decreases excitability of dentate gyrus and accelerates maturation of adult-born granule cells |
| title_short |
Chronic pregabalin treatment decreases excitability of dentate gyrus and accelerates maturation of adult-born granule cells |
| title_full |
Chronic pregabalin treatment decreases excitability of dentate gyrus and accelerates maturation of adult-born granule cells |
| title_fullStr |
Chronic pregabalin treatment decreases excitability of dentate gyrus and accelerates maturation of adult-born granule cells |
| title_full_unstemmed |
Chronic pregabalin treatment decreases excitability of dentate gyrus and accelerates maturation of adult-born granule cells |
| title_sort |
chronic pregabalin treatment decreases excitability of dentate gyrus and accelerates maturation of adult-born granule cells |
| url |
http://hdl.handle.net/20.500.12110/paper_00223042_v140_n2_p257_Lempel |
| work_keys_str_mv |
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| _version_ |
1807319225122947072 |