N-nitrosomelatonin enhances photic synchronization of mammalian circadian rhythms

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Most physiological processes in mammals are synchronized to the daily light:dark cycle by a circadian clock located in the hypothalamic suprachiasmatic nucleus. Signal transduction of light-induced phase advances of the clock is mediated through a neuronal nitric oxide synthase-guanilyl cyclase path...

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Autores principales:	Baidanoff, F.M., Plano, S.A., Doctorovich, F., Suárez, S.A., Golombek, D.A., Chiesa, J.J.
Formato:	JOUR
Materias:	circadian jet lag N-nitrosomelatonin nitric oxide suprachiasmatic nucleus melatonin melatonin derivative n nitrosomelatonin nitrate nitric oxide synthase nitrite PER1 protein protein c fos unclassified drug adult animal experiment animal model animal tissue article chronobiology circadian rhythm controlled study drug mechanism immunoreactivity in vivo study light dark cycle locomotion male nonhuman photic synchronization photoperiodicity priority journal Cricetinae Mammalia Murinae Animals Circadian Rhythm Male Melatonin Mesocricetus Motor Activity Nitroso Compounds Photic Stimulation Photoperiod Suprachiasmatic Nucleus
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_00223042_v129_n1_p60_Baidanoff
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_00223042_v129_n1_p60_Baidanoff
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spelling	todo:paper_00223042_v129_n1_p60_Baidanoff2023-10-03T14:30:50Z N-nitrosomelatonin enhances photic synchronization of mammalian circadian rhythms Baidanoff, F.M. Plano, S.A. Doctorovich, F. Suárez, S.A. Golombek, D.A. Chiesa, J.J. circadian jet lag N-nitrosomelatonin nitric oxide suprachiasmatic nucleus melatonin melatonin derivative n nitrosomelatonin nitrate nitric oxide nitric oxide synthase nitrite PER1 protein protein c fos unclassified drug adult animal experiment animal model animal tissue article chronobiology circadian rhythm controlled study drug mechanism immunoreactivity in vivo study jet lag light dark cycle locomotion male nonhuman photic synchronization photoperiodicity priority journal suprachiasmatic nucleus Cricetinae Mammalia Murinae circadian jet lag N-nitrosomelatonin nitric oxide suprachiasmatic nucleus Animals Circadian Rhythm Cricetinae Male Melatonin Mesocricetus Motor Activity Nitroso Compounds Photic Stimulation Photoperiod Suprachiasmatic Nucleus Most physiological processes in mammals are synchronized to the daily light:dark cycle by a circadian clock located in the hypothalamic suprachiasmatic nucleus. Signal transduction of light-induced phase advances of the clock is mediated through a neuronal nitric oxide synthase-guanilyl cyclase pathway. We have employed a novel nitric oxide-donor, N-nitrosomelatonin, to enhance the photic synchronization of circadian rhythms in hamsters. The intraperitoneal administration of this drug before a sub-saturating light pulse at circadian time 18 generated a twofold increase of locomotor rhythm phase-advances, having no effect over saturating light pulses. This potentiation was also obtained even when inhibiting suprachiasmatic nitric oxide synthase activity. However, N-nitrosomelatonin had no effect on light-induced phase delays at circadian time 14. The photic-enhancing effects were correlated with an increased suprachiasmatic immunoreactivity of FBJ murine osteosarcoma viral oncogene and period1. Moreover, in vivo nitric oxide release by N-nitrosomelatonin was verified by measuring nitrate and nitrite levels in suprachiasmatic nuclei homogenates. The compound also accelerated resynchronization to an abrupt 6-h advance in the light:dark cycle (but not resynchronization to a 6-h delay). Here, we demonstrate the chronobiotic properties of N-nitrosomelatonin, emphasizing the importance of nitric oxide-mediated transduction for circadian phase advances. © 2013 International Society for Neurochemistry. Fil:Doctorovich, F. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Suárez, S.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Golombek, D.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Chiesa, J.J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00223042_v129_n1_p60_Baidanoff
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	circadian jet lag N-nitrosomelatonin nitric oxide suprachiasmatic nucleus melatonin melatonin derivative n nitrosomelatonin nitrate nitric oxide nitric oxide synthase nitrite PER1 protein protein c fos unclassified drug adult animal experiment animal model animal tissue article chronobiology circadian rhythm controlled study drug mechanism immunoreactivity in vivo study jet lag light dark cycle locomotion male nonhuman photic synchronization photoperiodicity priority journal suprachiasmatic nucleus Cricetinae Mammalia Murinae circadian jet lag N-nitrosomelatonin nitric oxide suprachiasmatic nucleus Animals Circadian Rhythm Cricetinae Male Melatonin Mesocricetus Motor Activity Nitroso Compounds Photic Stimulation Photoperiod Suprachiasmatic Nucleus
spellingShingle	circadian jet lag N-nitrosomelatonin nitric oxide suprachiasmatic nucleus melatonin melatonin derivative n nitrosomelatonin nitrate nitric oxide nitric oxide synthase nitrite PER1 protein protein c fos unclassified drug adult animal experiment animal model animal tissue article chronobiology circadian rhythm controlled study drug mechanism immunoreactivity in vivo study jet lag light dark cycle locomotion male nonhuman photic synchronization photoperiodicity priority journal suprachiasmatic nucleus Cricetinae Mammalia Murinae circadian jet lag N-nitrosomelatonin nitric oxide suprachiasmatic nucleus Animals Circadian Rhythm Cricetinae Male Melatonin Mesocricetus Motor Activity Nitroso Compounds Photic Stimulation Photoperiod Suprachiasmatic Nucleus Baidanoff, F.M. Plano, S.A. Doctorovich, F. Suárez, S.A. Golombek, D.A. Chiesa, J.J. N-nitrosomelatonin enhances photic synchronization of mammalian circadian rhythms
topic_facet	circadian jet lag N-nitrosomelatonin nitric oxide suprachiasmatic nucleus melatonin melatonin derivative n nitrosomelatonin nitrate nitric oxide nitric oxide synthase nitrite PER1 protein protein c fos unclassified drug adult animal experiment animal model animal tissue article chronobiology circadian rhythm controlled study drug mechanism immunoreactivity in vivo study jet lag light dark cycle locomotion male nonhuman photic synchronization photoperiodicity priority journal suprachiasmatic nucleus Cricetinae Mammalia Murinae circadian jet lag N-nitrosomelatonin nitric oxide suprachiasmatic nucleus Animals Circadian Rhythm Cricetinae Male Melatonin Mesocricetus Motor Activity Nitroso Compounds Photic Stimulation Photoperiod Suprachiasmatic Nucleus
description	Most physiological processes in mammals are synchronized to the daily light:dark cycle by a circadian clock located in the hypothalamic suprachiasmatic nucleus. Signal transduction of light-induced phase advances of the clock is mediated through a neuronal nitric oxide synthase-guanilyl cyclase pathway. We have employed a novel nitric oxide-donor, N-nitrosomelatonin, to enhance the photic synchronization of circadian rhythms in hamsters. The intraperitoneal administration of this drug before a sub-saturating light pulse at circadian time 18 generated a twofold increase of locomotor rhythm phase-advances, having no effect over saturating light pulses. This potentiation was also obtained even when inhibiting suprachiasmatic nitric oxide synthase activity. However, N-nitrosomelatonin had no effect on light-induced phase delays at circadian time 14. The photic-enhancing effects were correlated with an increased suprachiasmatic immunoreactivity of FBJ murine osteosarcoma viral oncogene and period1. Moreover, in vivo nitric oxide release by N-nitrosomelatonin was verified by measuring nitrate and nitrite levels in suprachiasmatic nuclei homogenates. The compound also accelerated resynchronization to an abrupt 6-h advance in the light:dark cycle (but not resynchronization to a 6-h delay). Here, we demonstrate the chronobiotic properties of N-nitrosomelatonin, emphasizing the importance of nitric oxide-mediated transduction for circadian phase advances. © 2013 International Society for Neurochemistry.
format	JOUR
author	Baidanoff, F.M. Plano, S.A. Doctorovich, F. Suárez, S.A. Golombek, D.A. Chiesa, J.J.
author_facet	Baidanoff, F.M. Plano, S.A. Doctorovich, F. Suárez, S.A. Golombek, D.A. Chiesa, J.J.
author_sort	Baidanoff, F.M.
title	N-nitrosomelatonin enhances photic synchronization of mammalian circadian rhythms
title_short	N-nitrosomelatonin enhances photic synchronization of mammalian circadian rhythms
title_full	N-nitrosomelatonin enhances photic synchronization of mammalian circadian rhythms
title_fullStr	N-nitrosomelatonin enhances photic synchronization of mammalian circadian rhythms
title_full_unstemmed	N-nitrosomelatonin enhances photic synchronization of mammalian circadian rhythms
title_sort	n-nitrosomelatonin enhances photic synchronization of mammalian circadian rhythms
url	http://hdl.handle.net/20.500.12110/paper_00223042_v129_n1_p60_Baidanoff
work_keys_str_mv	AT baidanofffm nnitrosomelatoninenhancesphoticsynchronizationofmammaliancircadianrhythms AT planosa nnitrosomelatoninenhancesphoticsynchronizationofmammaliancircadianrhythms AT doctorovichf nnitrosomelatoninenhancesphoticsynchronizationofmammaliancircadianrhythms AT suarezsa nnitrosomelatoninenhancesphoticsynchronizationofmammaliancircadianrhythms AT golombekda nnitrosomelatoninenhancesphoticsynchronizationofmammaliancircadianrhythms AT chiesajj nnitrosomelatoninenhancesphoticsynchronizationofmammaliancircadianrhythms
_version_	1807319085307920384

N-nitrosomelatonin enhances photic synchronization of mammalian circadian rhythms

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