Multiparametric Fluorescence Detection of Early Stages in the Amyloid Protein Aggregation of Pyrene-labeled α-Synuclein

The aggregation of α-synuclein, a presynaptic protein, has an important role in the etiology of Parkinson's disease. Oligomers or protofibrils adopting the cross-β-sheet structure characteristic of fibrillating amyloid proteins are presumed to be the primary cytotoxic species. Current technique...

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Detalles Bibliográficos
Autores principales: Thirunavukkuarasu, S., Jares-Erijman, E.A., Jovin, T.M.
Formato: JOUR
Materias:
fibrillization
flourescence anisotropy
neurodegenerative
oligomers
Parkinson's disease
alpha synuclein
pyrene
anisotropy
article
fluorescence
human
in vivo study
kinetics
Parkinson disease
point mutation
priority journal
protein aggregation
protein analysis
alpha-Synuclein
Amino Acid Sequence
Amyloid
Anisotropy
Fluorescent Dyes
Humans
Molecular Sequence Data
Mutagenesis, Site-Directed
Parkinson Disease
Protein Folding
Protein Structure, Quaternary
Pyrenes
Spectrometry, Fluorescence
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00222836_v378_n5_p1064_Thirunavukkuarasu
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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