Microwave-assisted synthesis of pyrrolo[2,1-b]thiazoles linked to a carbohydrate moiety

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Herein, we describe the synthesis of pyrrolo[2,1-b]thiazoles substituted on C-2 or C-5 with a protected carbohydrate moiety. The new fused bicyclic heterocycles were obtained via thiazole intermediates, and the N-alkylation step was assisted by microwave irradiation. The new products were completely...

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Autores principales: Barradas, J.S., Errea, M.I., Sepúlveda, C., Damonte, E.B., D'Accorso, N.B.
Formato: JOUR
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_0022152X_v51_n1_p96_Barradas
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_0022152X_v51_n1_p96_Barradas
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spelling todo:paper_0022152X_v51_n1_p96_Barradas2023-10-03T14:27:50Z Microwave-assisted synthesis of pyrrolo[2,1-b]thiazoles linked to a carbohydrate moiety Barradas, J.S. Errea, M.I. Sepúlveda, C. Damonte, E.B. D'Accorso, N.B. Herein, we describe the synthesis of pyrrolo[2,1-b]thiazoles substituted on C-2 or C-5 with a protected carbohydrate moiety. The new fused bicyclic heterocycles were obtained via thiazole intermediates, and the N-alkylation step was assisted by microwave irradiation. The new products were completely characterized by physical and spectroscopic techniques. The cytotoxicity and antiviral activity against Junín virus of the methylated derivates was also evaluated. © 2013 HeteroCorporation. Fil:Barradas, J.S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Errea, M.I. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Sepúlveda, C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Damonte, E.B. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:D'Accorso, N.B. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_0022152X_v51_n1_p96_Barradas
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
description Herein, we describe the synthesis of pyrrolo[2,1-b]thiazoles substituted on C-2 or C-5 with a protected carbohydrate moiety. The new fused bicyclic heterocycles were obtained via thiazole intermediates, and the N-alkylation step was assisted by microwave irradiation. The new products were completely characterized by physical and spectroscopic techniques. The cytotoxicity and antiviral activity against Junín virus of the methylated derivates was also evaluated. © 2013 HeteroCorporation.
format JOUR
author Barradas, J.S.
Errea, M.I.
Sepúlveda, C.
Damonte, E.B.
D'Accorso, N.B.
spellingShingle Barradas, J.S.
Errea, M.I.
Sepúlveda, C.
Damonte, E.B.
D'Accorso, N.B.
Microwave-assisted synthesis of pyrrolo[2,1-b]thiazoles linked to a carbohydrate moiety
author_facet Barradas, J.S.
Errea, M.I.
Sepúlveda, C.
Damonte, E.B.
D'Accorso, N.B.
author_sort Barradas, J.S.
title Microwave-assisted synthesis of pyrrolo[2,1-b]thiazoles linked to a carbohydrate moiety
title_short Microwave-assisted synthesis of pyrrolo[2,1-b]thiazoles linked to a carbohydrate moiety
title_full Microwave-assisted synthesis of pyrrolo[2,1-b]thiazoles linked to a carbohydrate moiety
title_fullStr Microwave-assisted synthesis of pyrrolo[2,1-b]thiazoles linked to a carbohydrate moiety
title_full_unstemmed Microwave-assisted synthesis of pyrrolo[2,1-b]thiazoles linked to a carbohydrate moiety
title_sort microwave-assisted synthesis of pyrrolo[2,1-b]thiazoles linked to a carbohydrate moiety
url http://hdl.handle.net/20.500.12110/paper_0022152X_v51_n1_p96_Barradas
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