Synthesis and Characterization of some Heterocyclic Derivatives by Cyclization of Carbohydrate Thiosemicarbazones. Part I

We report the synthesis of 2,3-dihydro-1,3,4-thiadiazoles and 1,3,4-thiadiazoles from 1,2:3,4-di-O-isopropylidene-α-D-galacto-1,6-hexodialdo-1,5-pyranose thiosemicarbazone. The physical and spectroscopic characterizations of the heterocyclic derivatives as well as the intermediate product are descri...

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Autores principales: Martins Alho, M.A., D'Accorso, N.B.
Formato: JOUR
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_0022152X_v34_n5_p1415_MartinsAlho
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
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spelling todo:paper_0022152X_v34_n5_p1415_MartinsAlho2023-10-03T14:27:43Z Synthesis and Characterization of some Heterocyclic Derivatives by Cyclization of Carbohydrate Thiosemicarbazones. Part I Martins Alho, M.A. D'Accorso, N.B. We report the synthesis of 2,3-dihydro-1,3,4-thiadiazoles and 1,3,4-thiadiazoles from 1,2:3,4-di-O-isopropylidene-α-D-galacto-1,6-hexodialdo-1,5-pyranose thiosemicarbazone. The physical and spectroscopic characterizations of the heterocyclic derivatives as well as the intermediate product are described. We present the prefered conformation in solution using computational calculations and spectroscopic data. The possibilities of chiral induction of the cyclization reaction are discussed. Fil:Martins Alho, M.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:D'Accorso, N.B. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_0022152X_v34_n5_p1415_MartinsAlho
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
description We report the synthesis of 2,3-dihydro-1,3,4-thiadiazoles and 1,3,4-thiadiazoles from 1,2:3,4-di-O-isopropylidene-α-D-galacto-1,6-hexodialdo-1,5-pyranose thiosemicarbazone. The physical and spectroscopic characterizations of the heterocyclic derivatives as well as the intermediate product are described. We present the prefered conformation in solution using computational calculations and spectroscopic data. The possibilities of chiral induction of the cyclization reaction are discussed.
format JOUR
author Martins Alho, M.A.
D'Accorso, N.B.
spellingShingle Martins Alho, M.A.
D'Accorso, N.B.
Synthesis and Characterization of some Heterocyclic Derivatives by Cyclization of Carbohydrate Thiosemicarbazones. Part I
author_facet Martins Alho, M.A.
D'Accorso, N.B.
author_sort Martins Alho, M.A.
title Synthesis and Characterization of some Heterocyclic Derivatives by Cyclization of Carbohydrate Thiosemicarbazones. Part I
title_short Synthesis and Characterization of some Heterocyclic Derivatives by Cyclization of Carbohydrate Thiosemicarbazones. Part I
title_full Synthesis and Characterization of some Heterocyclic Derivatives by Cyclization of Carbohydrate Thiosemicarbazones. Part I
title_fullStr Synthesis and Characterization of some Heterocyclic Derivatives by Cyclization of Carbohydrate Thiosemicarbazones. Part I
title_full_unstemmed Synthesis and Characterization of some Heterocyclic Derivatives by Cyclization of Carbohydrate Thiosemicarbazones. Part I
title_sort synthesis and characterization of some heterocyclic derivatives by cyclization of carbohydrate thiosemicarbazones. part i
url http://hdl.handle.net/20.500.12110/paper_0022152X_v34_n5_p1415_MartinsAlho
work_keys_str_mv AT martinsalhoma synthesisandcharacterizationofsomeheterocyclicderivativesbycyclizationofcarbohydratethiosemicarbazonesparti
AT daccorsonb synthesisandcharacterizationofsomeheterocyclicderivativesbycyclizationofcarbohydratethiosemicarbazonesparti
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