Differentiation of junin virus and antigenic variants isolated in vivo by kinetic neutralization assays

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The major natural reservoir of Junin virus, the aetiological agent of Argentine haemorrhagic fever, is the cricetid Calomys musculinus. Neonatal animals experimentally infected with Junin virus (XJCl3 strain) developed typical disease and approximately 80% of them died. Most survivors become persist...

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Autores principales: Alche, L.E., Coto, C.E.
Formato: JOUR
Materias:
antigenic variation
Junin virus
nonhuman
Animalia
Argentina (fish)
Calomys musculinus
Cricetinae
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00221317_v69_n8_p2123_Alche
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_00221317_v69_n8_p2123_Alche
record_format dspace
spelling todo:paper_00221317_v69_n8_p2123_Alche2023-10-03T14:27:23Z Differentiation of junin virus and antigenic variants isolated in vivo by kinetic neutralization assays Alche, L.E. Coto, C.E. antigenic variation Junin virus nonhuman Animalia Argentina (fish) Calomys musculinus Cricetinae Junin virus The major natural reservoir of Junin virus, the aetiological agent of Argentine haemorrhagic fever, is the cricetid Calomys musculinus. Neonatal animals experimentally infected with Junin virus (XJCl3 strain) developed typical disease and approximately 80% of them died. Most survivors become persistently infected. Antigenically variant viruses were isolated from the blood and brain of infected cricetids during the acute and chronic stages of the disease. These variants could be distinguished from the parental strain by kinetic neutralization assays using polyclonal antibodies. Some biological properties were shared with the parental virus strain including its virulence for newborn C. musculinus. These variant viruses may play a major role in chronic disease since we have shown that a viral isolate from an infected brain was poorly neutralized by serum obtained from the same animal. Fil:Alche, L.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Coto, C.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00221317_v69_n8_p2123_Alche
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic antigenic variation
Junin virus
nonhuman
Animalia
Argentina (fish)
Calomys musculinus
Cricetinae
Junin virus
spellingShingle antigenic variation
Junin virus
nonhuman
Animalia
Argentina (fish)
Calomys musculinus
Cricetinae
Junin virus
Alche, L.E.
Coto, C.E.
Differentiation of junin virus and antigenic variants isolated in vivo by kinetic neutralization assays
topic_facet antigenic variation
Junin virus
nonhuman
Animalia
Argentina (fish)
Calomys musculinus
Cricetinae
Junin virus
description The major natural reservoir of Junin virus, the aetiological agent of Argentine haemorrhagic fever, is the cricetid Calomys musculinus. Neonatal animals experimentally infected with Junin virus (XJCl3 strain) developed typical disease and approximately 80% of them died. Most survivors become persistently infected. Antigenically variant viruses were isolated from the blood and brain of infected cricetids during the acute and chronic stages of the disease. These variants could be distinguished from the parental strain by kinetic neutralization assays using polyclonal antibodies. Some biological properties were shared with the parental virus strain including its virulence for newborn C. musculinus. These variant viruses may play a major role in chronic disease since we have shown that a viral isolate from an infected brain was poorly neutralized by serum obtained from the same animal.
format JOUR
author Alche, L.E.
Coto, C.E.
author_facet Alche, L.E.
Coto, C.E.
author_sort Alche, L.E.
title Differentiation of junin virus and antigenic variants isolated in vivo by kinetic neutralization assays
title_short Differentiation of junin virus and antigenic variants isolated in vivo by kinetic neutralization assays
title_full Differentiation of junin virus and antigenic variants isolated in vivo by kinetic neutralization assays
title_fullStr Differentiation of junin virus and antigenic variants isolated in vivo by kinetic neutralization assays
title_full_unstemmed Differentiation of junin virus and antigenic variants isolated in vivo by kinetic neutralization assays
title_sort differentiation of junin virus and antigenic variants isolated in vivo by kinetic neutralization assays
url http://hdl.handle.net/20.500.12110/paper_00221317_v69_n8_p2123_Alche
work_keys_str_mv AT alchele differentiationofjuninvirusandantigenicvariantsisolatedinvivobykineticneutralizationassays
AT cotoce differentiationofjuninvirusandantigenicvariantsisolatedinvivobykineticneutralizationassays
_version_ 1807314380197462016

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