Cellular proliferation rate and insulin-like growth factor binding protein (IGFBP)-2 and IGFBP-3 and estradiol receptor alpha expression in the mammary gland of dairy heifers naturally infected with gastrointestinal nematodes during development

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Mammary ductal morphogenesis during prepuberty occurs mainly in response to insulin-like growth factor-1 (IGF-1) and estradiol stimulation. Dairy heifers infected with gastrointestinal nematodes have reduced IGF-1 levels, accompanied by reduced growth rate, delayed puberty onset, and lower parenchym...

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Autores principales:	Perri, A.F., Dallard, B.E., Baravalle, C., Licoff, N., Formía, N., Ortega, H.H., Becú-Villalobos, D., Mejia, M.E., Lacau-Mengido, I.M.
Formato:	JOUR
Materias:	Estradiol receptor alpha Insulin-like growth factor binding protein Prepubertal mammary gland Proliferating cell nuclear antigen anthelmintic agent estradiol estrogen receptor alpha fenbendazole ivermectin levamisole somatomedin binding protein 2 somatomedin binding protein 3 somatomedin C animal bovine cell proliferation controlled study cytology female gastrointestinal tract genetics metabolism nematode nematodiasis parasitology randomized controlled trial signal transduction udder veterinary Animals Anthelmintics Cattle Cell Proliferation Estradiol Estrogen Receptor alpha Female Fenbendazole Gastrointestinal Tract Insulin-Like Growth Factor Binding Protein 2 Insulin-Like Growth Factor Binding Protein 3 Insulin-Like Growth Factor I Ivermectin Levamisole Mammary Glands, Animal Nematoda Nematode Infections Signal Transduction
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_00220302_v97_n8_p4985_Perri
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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spelling	todo:paper_00220302_v97_n8_p4985_Perri2023-10-03T14:25:29Z Cellular proliferation rate and insulin-like growth factor binding protein (IGFBP)-2 and IGFBP-3 and estradiol receptor alpha expression in the mammary gland of dairy heifers naturally infected with gastrointestinal nematodes during development Perri, A.F. Dallard, B.E. Baravalle, C. Licoff, N. Formía, N. Ortega, H.H. Becú-Villalobos, D. Mejia, M.E. Lacau-Mengido, I.M. Estradiol receptor alpha Insulin-like growth factor binding protein Prepubertal mammary gland Proliferating cell nuclear antigen anthelmintic agent estradiol estrogen receptor alpha fenbendazole ivermectin levamisole somatomedin binding protein 2 somatomedin binding protein 3 somatomedin C animal bovine cell proliferation controlled study cytology female gastrointestinal tract genetics metabolism nematode nematodiasis parasitology randomized controlled trial signal transduction udder veterinary Animals Anthelmintics Cattle Cell Proliferation Estradiol Estrogen Receptor alpha Female Fenbendazole Gastrointestinal Tract Insulin-Like Growth Factor Binding Protein 2 Insulin-Like Growth Factor Binding Protein 3 Insulin-Like Growth Factor I Ivermectin Levamisole Mammary Glands, Animal Nematoda Nematode Infections Signal Transduction Mammary ductal morphogenesis during prepuberty occurs mainly in response to insulin-like growth factor-1 (IGF-1) and estradiol stimulation. Dairy heifers infected with gastrointestinal nematodes have reduced IGF-1 levels, accompanied by reduced growth rate, delayed puberty onset, and lower parenchyma-stroma relationship in their mammary glands. Immunohistochemical studies were undertaken to determine variations in cell division rate, IGF-1 system components, and estradiol receptors (ESR) during peripubertal development in the mammary glands of antiparasitic-treated and untreated Holstein heifers naturally infected with gastrointestinal nematodes. Mammary biopsies were taken at 20, 30, 40, and 70 wk of age. Proliferating cell nuclear antigen immunolabeling, evident in nuclei, tended to be higher in the parenchyma of the glands from treated heifers than in those from untreated. Insulin-like growth factor binding proteins (IGFBP) type 2 and type 3 immunolabeling was cytoplasmic and was evident in stroma and parenchyma. The IGFBP2-labeled area was lower in treated than in untreated heifers. In the treated group, a maximal expression of this protein was seen at 40 wk of age, whereas in the untreated group the labeling remained constant. No differences were observed for IGFBP3 between treatment groups or during development. Immunolabeling for α ESR (ESR1) was evident in parenchymal nuclei and was higher in treated than in untreated heifers. In the treated group, ESR1 peaked at 30 wk of age and then decreased. These results demonstrate that the parasite burden in young heifers negatively influence mammary gland development, affecting cell division rate and parameters related to estradiol and IGF-1 signaling in the gland. © 2014 American Dairy Science Association. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00220302_v97_n8_p4985_Perri
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Estradiol receptor alpha Insulin-like growth factor binding protein Prepubertal mammary gland Proliferating cell nuclear antigen anthelmintic agent estradiol estrogen receptor alpha fenbendazole ivermectin levamisole somatomedin binding protein 2 somatomedin binding protein 3 somatomedin C animal bovine cell proliferation controlled study cytology female gastrointestinal tract genetics metabolism nematode nematodiasis parasitology randomized controlled trial signal transduction udder veterinary Animals Anthelmintics Cattle Cell Proliferation Estradiol Estrogen Receptor alpha Female Fenbendazole Gastrointestinal Tract Insulin-Like Growth Factor Binding Protein 2 Insulin-Like Growth Factor Binding Protein 3 Insulin-Like Growth Factor I Ivermectin Levamisole Mammary Glands, Animal Nematoda Nematode Infections Signal Transduction
spellingShingle	Estradiol receptor alpha Insulin-like growth factor binding protein Prepubertal mammary gland Proliferating cell nuclear antigen anthelmintic agent estradiol estrogen receptor alpha fenbendazole ivermectin levamisole somatomedin binding protein 2 somatomedin binding protein 3 somatomedin C animal bovine cell proliferation controlled study cytology female gastrointestinal tract genetics metabolism nematode nematodiasis parasitology randomized controlled trial signal transduction udder veterinary Animals Anthelmintics Cattle Cell Proliferation Estradiol Estrogen Receptor alpha Female Fenbendazole Gastrointestinal Tract Insulin-Like Growth Factor Binding Protein 2 Insulin-Like Growth Factor Binding Protein 3 Insulin-Like Growth Factor I Ivermectin Levamisole Mammary Glands, Animal Nematoda Nematode Infections Signal Transduction Perri, A.F. Dallard, B.E. Baravalle, C. Licoff, N. Formía, N. Ortega, H.H. Becú-Villalobos, D. Mejia, M.E. Lacau-Mengido, I.M. Cellular proliferation rate and insulin-like growth factor binding protein (IGFBP)-2 and IGFBP-3 and estradiol receptor alpha expression in the mammary gland of dairy heifers naturally infected with gastrointestinal nematodes during development
topic_facet	Estradiol receptor alpha Insulin-like growth factor binding protein Prepubertal mammary gland Proliferating cell nuclear antigen anthelmintic agent estradiol estrogen receptor alpha fenbendazole ivermectin levamisole somatomedin binding protein 2 somatomedin binding protein 3 somatomedin C animal bovine cell proliferation controlled study cytology female gastrointestinal tract genetics metabolism nematode nematodiasis parasitology randomized controlled trial signal transduction udder veterinary Animals Anthelmintics Cattle Cell Proliferation Estradiol Estrogen Receptor alpha Female Fenbendazole Gastrointestinal Tract Insulin-Like Growth Factor Binding Protein 2 Insulin-Like Growth Factor Binding Protein 3 Insulin-Like Growth Factor I Ivermectin Levamisole Mammary Glands, Animal Nematoda Nematode Infections Signal Transduction
description	Mammary ductal morphogenesis during prepuberty occurs mainly in response to insulin-like growth factor-1 (IGF-1) and estradiol stimulation. Dairy heifers infected with gastrointestinal nematodes have reduced IGF-1 levels, accompanied by reduced growth rate, delayed puberty onset, and lower parenchyma-stroma relationship in their mammary glands. Immunohistochemical studies were undertaken to determine variations in cell division rate, IGF-1 system components, and estradiol receptors (ESR) during peripubertal development in the mammary glands of antiparasitic-treated and untreated Holstein heifers naturally infected with gastrointestinal nematodes. Mammary biopsies were taken at 20, 30, 40, and 70 wk of age. Proliferating cell nuclear antigen immunolabeling, evident in nuclei, tended to be higher in the parenchyma of the glands from treated heifers than in those from untreated. Insulin-like growth factor binding proteins (IGFBP) type 2 and type 3 immunolabeling was cytoplasmic and was evident in stroma and parenchyma. The IGFBP2-labeled area was lower in treated than in untreated heifers. In the treated group, a maximal expression of this protein was seen at 40 wk of age, whereas in the untreated group the labeling remained constant. No differences were observed for IGFBP3 between treatment groups or during development. Immunolabeling for α ESR (ESR1) was evident in parenchymal nuclei and was higher in treated than in untreated heifers. In the treated group, ESR1 peaked at 30 wk of age and then decreased. These results demonstrate that the parasite burden in young heifers negatively influence mammary gland development, affecting cell division rate and parameters related to estradiol and IGF-1 signaling in the gland. © 2014 American Dairy Science Association.
format	JOUR
author	Perri, A.F. Dallard, B.E. Baravalle, C. Licoff, N. Formía, N. Ortega, H.H. Becú-Villalobos, D. Mejia, M.E. Lacau-Mengido, I.M.
author_facet	Perri, A.F. Dallard, B.E. Baravalle, C. Licoff, N. Formía, N. Ortega, H.H. Becú-Villalobos, D. Mejia, M.E. Lacau-Mengido, I.M.
author_sort	Perri, A.F.
title	Cellular proliferation rate and insulin-like growth factor binding protein (IGFBP)-2 and IGFBP-3 and estradiol receptor alpha expression in the mammary gland of dairy heifers naturally infected with gastrointestinal nematodes during development
title_short	Cellular proliferation rate and insulin-like growth factor binding protein (IGFBP)-2 and IGFBP-3 and estradiol receptor alpha expression in the mammary gland of dairy heifers naturally infected with gastrointestinal nematodes during development
title_full	Cellular proliferation rate and insulin-like growth factor binding protein (IGFBP)-2 and IGFBP-3 and estradiol receptor alpha expression in the mammary gland of dairy heifers naturally infected with gastrointestinal nematodes during development
title_fullStr	Cellular proliferation rate and insulin-like growth factor binding protein (IGFBP)-2 and IGFBP-3 and estradiol receptor alpha expression in the mammary gland of dairy heifers naturally infected with gastrointestinal nematodes during development
title_full_unstemmed	Cellular proliferation rate and insulin-like growth factor binding protein (IGFBP)-2 and IGFBP-3 and estradiol receptor alpha expression in the mammary gland of dairy heifers naturally infected with gastrointestinal nematodes during development
title_sort	cellular proliferation rate and insulin-like growth factor binding protein (igfbp)-2 and igfbp-3 and estradiol receptor alpha expression in the mammary gland of dairy heifers naturally infected with gastrointestinal nematodes during development
url	http://hdl.handle.net/20.500.12110/paper_00220302_v97_n8_p4985_Perri
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Cellular proliferation rate and insulin-like growth factor binding protein (IGFBP)-2 and IGFBP-3 and estradiol receptor alpha expression in the mammary gland of dairy heifers naturally infected with gastrointestinal nematodes during development

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