High levels of matrix metalloproteinases regulate proliferation and hormone secretion in pituitary cells
Beside the digestion of the extracellular matrix during tumor invasion and metastasis, more recently, new functions for matrix metalloproteinases (MMPs) have been proposed. We studied the expression and function of these enzymes in pituitary cells. We observed the activities of MMP-2 and MMP-9 toget...
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todo:paper_0021972X_v85_n1_p263_Pereda2023-10-03T14:25:04Z High levels of matrix metalloproteinases regulate proliferation and hormone secretion in pituitary cells Pereda, M.P. Ledda, M.F. Goldberg, V. Chervín, A. Carrizo, G. Molina, H. Müller, A. Renner, U. Podhajcer, O. Arzt, E. Stalla, G.K. batimastat matrix metalloproteinase adult aged article cell proliferation drug use enzyme activity female growth regulation human hypophysis adenoma hypophysis function major clinical study male priority journal Adenoma Adult Aged Aged, 80 and over Animals Blotting, Northern Cell Division Female Humans Male Matrix Metalloproteinase 2 Matrix Metalloproteinase 9 Matrix Metalloproteinases Middle Aged Phenylalanine Pituitary Gland Pituitary Hormones Pituitary Neoplasms Protease Inhibitors Rats Thiophenes Tissue Inhibitor of Metalloproteinase-1 Tissue Inhibitor of Metalloproteinase-2 Tumor Cells, Cultured Tumor Stem Cells Beside the digestion of the extracellular matrix during tumor invasion and metastasis, more recently, new functions for matrix metalloproteinases (MMPs) have been proposed. We studied the expression and function of these enzymes in pituitary cells. We observed the activities of MMP-2 and MMP-9 together with expression of membrane-type MMP and tissue inhibitor of metalloproteinase-1 in all types of human pituitary adenomas. We found surprisingly high levels of MMP activity and low levels of tissue inhibitor of metalloproteinases, indicating a high level of extracellular matrix-degrading activity in pituitary adenomas. To examine the function of metalloproteinase activity in pituitary cells we used the synthetic MMP inhibitor batimastat. These studies demonstrate that MMPs secreted by pituitary cells can release growth factors anchored to the extracellular matrix that, in turn, control pituitary cell proliferation and hormone secretion. These results define a new additional mechanism for the control of pituitary hormone secretion and indicate new potential therapeutic targets for pituitary adenomas. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_0021972X_v85_n1_p263_Pereda |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
batimastat matrix metalloproteinase adult aged article cell proliferation drug use enzyme activity female growth regulation human hypophysis adenoma hypophysis function major clinical study male priority journal Adenoma Adult Aged Aged, 80 and over Animals Blotting, Northern Cell Division Female Humans Male Matrix Metalloproteinase 2 Matrix Metalloproteinase 9 Matrix Metalloproteinases Middle Aged Phenylalanine Pituitary Gland Pituitary Hormones Pituitary Neoplasms Protease Inhibitors Rats Thiophenes Tissue Inhibitor of Metalloproteinase-1 Tissue Inhibitor of Metalloproteinase-2 Tumor Cells, Cultured Tumor Stem Cells |
| spellingShingle |
batimastat matrix metalloproteinase adult aged article cell proliferation drug use enzyme activity female growth regulation human hypophysis adenoma hypophysis function major clinical study male priority journal Adenoma Adult Aged Aged, 80 and over Animals Blotting, Northern Cell Division Female Humans Male Matrix Metalloproteinase 2 Matrix Metalloproteinase 9 Matrix Metalloproteinases Middle Aged Phenylalanine Pituitary Gland Pituitary Hormones Pituitary Neoplasms Protease Inhibitors Rats Thiophenes Tissue Inhibitor of Metalloproteinase-1 Tissue Inhibitor of Metalloproteinase-2 Tumor Cells, Cultured Tumor Stem Cells Pereda, M.P. Ledda, M.F. Goldberg, V. Chervín, A. Carrizo, G. Molina, H. Müller, A. Renner, U. Podhajcer, O. Arzt, E. Stalla, G.K. High levels of matrix metalloproteinases regulate proliferation and hormone secretion in pituitary cells |
| topic_facet |
batimastat matrix metalloproteinase adult aged article cell proliferation drug use enzyme activity female growth regulation human hypophysis adenoma hypophysis function major clinical study male priority journal Adenoma Adult Aged Aged, 80 and over Animals Blotting, Northern Cell Division Female Humans Male Matrix Metalloproteinase 2 Matrix Metalloproteinase 9 Matrix Metalloproteinases Middle Aged Phenylalanine Pituitary Gland Pituitary Hormones Pituitary Neoplasms Protease Inhibitors Rats Thiophenes Tissue Inhibitor of Metalloproteinase-1 Tissue Inhibitor of Metalloproteinase-2 Tumor Cells, Cultured Tumor Stem Cells |
| description |
Beside the digestion of the extracellular matrix during tumor invasion and metastasis, more recently, new functions for matrix metalloproteinases (MMPs) have been proposed. We studied the expression and function of these enzymes in pituitary cells. We observed the activities of MMP-2 and MMP-9 together with expression of membrane-type MMP and tissue inhibitor of metalloproteinase-1 in all types of human pituitary adenomas. We found surprisingly high levels of MMP activity and low levels of tissue inhibitor of metalloproteinases, indicating a high level of extracellular matrix-degrading activity in pituitary adenomas. To examine the function of metalloproteinase activity in pituitary cells we used the synthetic MMP inhibitor batimastat. These studies demonstrate that MMPs secreted by pituitary cells can release growth factors anchored to the extracellular matrix that, in turn, control pituitary cell proliferation and hormone secretion. These results define a new additional mechanism for the control of pituitary hormone secretion and indicate new potential therapeutic targets for pituitary adenomas. |
| format |
JOUR |
| author |
Pereda, M.P. Ledda, M.F. Goldberg, V. Chervín, A. Carrizo, G. Molina, H. Müller, A. Renner, U. Podhajcer, O. Arzt, E. Stalla, G.K. |
| author_facet |
Pereda, M.P. Ledda, M.F. Goldberg, V. Chervín, A. Carrizo, G. Molina, H. Müller, A. Renner, U. Podhajcer, O. Arzt, E. Stalla, G.K. |
| author_sort |
Pereda, M.P. |
| title |
High levels of matrix metalloproteinases regulate proliferation and hormone secretion in pituitary cells |
| title_short |
High levels of matrix metalloproteinases regulate proliferation and hormone secretion in pituitary cells |
| title_full |
High levels of matrix metalloproteinases regulate proliferation and hormone secretion in pituitary cells |
| title_fullStr |
High levels of matrix metalloproteinases regulate proliferation and hormone secretion in pituitary cells |
| title_full_unstemmed |
High levels of matrix metalloproteinases regulate proliferation and hormone secretion in pituitary cells |
| title_sort |
high levels of matrix metalloproteinases regulate proliferation and hormone secretion in pituitary cells |
| url |
http://hdl.handle.net/20.500.12110/paper_0021972X_v85_n1_p263_Pereda |
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