The 90-kDa heat-shock protein (Hsp90)-binding immunophilin FKBP51 is a mitochondrial protein that translocates to the nucleus to protect cells against oxidative stress

Mostrar todas las versiones(3)

Confocal microscopy images revealed that the tetratricopeptide repeat motif (TPR) domain immunophilin FKBP51 shows colocalization with the specific mitochondrial marker Mito-Tracker. Signal specificity was tested with different antibodies and by FKBP51 knockdown. This unexpected subcellular localiza...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Gallo, L.I., Lagadari, M., Piwien-Pilipuk, G., Galigniana, M.D.
Formato: JOUR
Materias:
Antiapoptotic
Biochemical fractionation
Co-localization studies
Colocalization
Glucocorticoid receptor
Heat-shock protein
Immunophilins
Mitochondrial marker
Mitochondrial protein
Over-expression
Stress response
Subcellular localizations
Tetratricopeptide repeat motif
Confocal microscopy
Proteins
Mitochondria
chaperone
fk 506 binding protein 51
glucocorticoid receptor
heat shock protein 70
heat shock protein 90
immunophilin
mitochondrial protein
unclassified drug
article
cell nucleus
cell protection
cell strain 3T3
cellular distribution
cellular stress response
complex formation
controlled study
electron microscopy
gene silencing
mitochondrion
oxidative stress
priority journal
protein analysis
protein domain
protein expression
protein function
protein localization
protein transport
tetratricopeptide repeat
3T3-L1 Cells
Active Transport, Cell Nucleus
Animals
Cell Nucleus
HSP70 Heat-Shock Proteins
HSP90 Heat-Shock Proteins
Humans
Mice
Mitochondrial Proteins
Mutation
Oxidative Stress
Protein Structure, Tertiary
Receptors, Glucocorticoid
Tacrolimus Binding Proteins
Vasconcellea candicans
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00219258_v286_n34_p30152_Gallo
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

Ejemplares similares

Ejemplares similares