Molecular epidemiology of domestic and sylvatic Trypanosoma cruzi infection in rural northwestern Argentina

Genetic diversity of Trypanosoma cruzi populations and parasite transmission dynamics have been well documented throughout the Americas, but few studies have been conducted in the Gran Chaco ecoregion, one of the most highly endemic areas for Chagas disease, caused by T. cruzi. In this study, we ass...

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Autores principales:	Cardinal, M.V., Lauricella, M.A., Ceballos, L.A., Lanati, L., Marcet, P.L., Levin, M.J., Kitron, U., Gürtler, R.E., Schijman, A.G.
Formato:	JOUR
Materias:	Cats Chagas disease Dogs Lineage Surveillance Triatoma infestans Trypanosoma cruzi Vector control canid disease vector epidemiology felid genetic variation parasite transmission protozoan rural area spatial distribution adult animal experiment animal model Argentina article controlled study disease transmission domestic animal geographical variation (species) household human molecular epidemiology mouse nonhuman polymerase chain reaction trypanosomiasis vector control Adult Aged Animals Animals, Domestic Animals, Wild Cat Diseases Chagas Disease Dog Diseases Feces Female Humans Male Middle Aged Molecular Epidemiology Rural Health Triatoma Young Adult South America Canis familiaris Mammalia
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_00207519_v38_n13_p1533_Cardinal
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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spelling	todo:paper_00207519_v38_n13_p1533_Cardinal2023-10-03T14:18:33Z Molecular epidemiology of domestic and sylvatic Trypanosoma cruzi infection in rural northwestern Argentina Cardinal, M.V. Lauricella, M.A. Ceballos, L.A. Lanati, L. Marcet, P.L. Levin, M.J. Kitron, U. Gürtler, R.E. Schijman, A.G. Cats Chagas disease Dogs Lineage Surveillance Triatoma infestans Trypanosoma cruzi Vector control canid Chagas disease disease vector epidemiology felid genetic variation parasite transmission protozoan rural area spatial distribution adult animal experiment animal model Argentina article controlled study disease transmission domestic animal geographical variation (species) household human molecular epidemiology mouse nonhuman polymerase chain reaction rural area Trypanosoma cruzi trypanosomiasis vector control Adult Aged Animals Animals, Domestic Animals, Wild Argentina Cat Diseases Cats Chagas Disease Dog Diseases Dogs Feces Female Humans Male Middle Aged Molecular Epidemiology Rural Health Triatoma Trypanosoma cruzi Young Adult Argentina South America Canis familiaris Mammalia Triatoma infestans Trypanosoma cruzi Genetic diversity of Trypanosoma cruzi populations and parasite transmission dynamics have been well documented throughout the Americas, but few studies have been conducted in the Gran Chaco ecoregion, one of the most highly endemic areas for Chagas disease, caused by T. cruzi. In this study, we assessed the distribution of T. cruzi lineages (identified by PCR strategies) in Triatoma infestans, domestic dogs, cats, humans and sylvatic mammals from two neighbouring rural areas with different histories of transmission and vector control in northern Argentina. Lineage II predominated amongst the 99 isolates characterised and lineage I amongst the six isolates obtained from sylvatic mammals. T. cruzi lineage IIe predominated in domestic habitats; it was found in 87% of 54 isolates from Tr. infestans, in 82% of 33 isolates from dogs, and in the four cats found infected. Domestic and sylvatic cycles overlapped in the study area in the late 1980s, when intense domestic transmission occurred, and still overlap marginally. The introduction of T. cruzi from sylvatic into domestic habitats is likely to occur very rarely in the current epidemiological context. The household distribution of T. cruzi lineages showed that Tr. infestans, dogs and cats from a given house compound shared the same parasite lineage in most cases. Based on molecular evidence, this result lends further support to the importance of dogs and cats as domestic reservoir hosts of T. cruzi. We believe that in Argentina, this is the first time that lineage IIc has been isolated from naturally infected domestic dogs and Tr. infestans. © 2008 Australian Society for Parasitology Inc. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00207519_v38_n13_p1533_Cardinal
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Cats Chagas disease Dogs Lineage Surveillance Triatoma infestans Trypanosoma cruzi Vector control canid Chagas disease disease vector epidemiology felid genetic variation parasite transmission protozoan rural area spatial distribution adult animal experiment animal model Argentina article controlled study disease transmission domestic animal geographical variation (species) household human molecular epidemiology mouse nonhuman polymerase chain reaction rural area Trypanosoma cruzi trypanosomiasis vector control Adult Aged Animals Animals, Domestic Animals, Wild Argentina Cat Diseases Cats Chagas Disease Dog Diseases Dogs Feces Female Humans Male Middle Aged Molecular Epidemiology Rural Health Triatoma Trypanosoma cruzi Young Adult Argentina South America Canis familiaris Mammalia Triatoma infestans Trypanosoma cruzi
spellingShingle	Cats Chagas disease Dogs Lineage Surveillance Triatoma infestans Trypanosoma cruzi Vector control canid Chagas disease disease vector epidemiology felid genetic variation parasite transmission protozoan rural area spatial distribution adult animal experiment animal model Argentina article controlled study disease transmission domestic animal geographical variation (species) household human molecular epidemiology mouse nonhuman polymerase chain reaction rural area Trypanosoma cruzi trypanosomiasis vector control Adult Aged Animals Animals, Domestic Animals, Wild Argentina Cat Diseases Cats Chagas Disease Dog Diseases Dogs Feces Female Humans Male Middle Aged Molecular Epidemiology Rural Health Triatoma Trypanosoma cruzi Young Adult Argentina South America Canis familiaris Mammalia Triatoma infestans Trypanosoma cruzi Cardinal, M.V. Lauricella, M.A. Ceballos, L.A. Lanati, L. Marcet, P.L. Levin, M.J. Kitron, U. Gürtler, R.E. Schijman, A.G. Molecular epidemiology of domestic and sylvatic Trypanosoma cruzi infection in rural northwestern Argentina
topic_facet	Cats Chagas disease Dogs Lineage Surveillance Triatoma infestans Trypanosoma cruzi Vector control canid Chagas disease disease vector epidemiology felid genetic variation parasite transmission protozoan rural area spatial distribution adult animal experiment animal model Argentina article controlled study disease transmission domestic animal geographical variation (species) household human molecular epidemiology mouse nonhuman polymerase chain reaction rural area Trypanosoma cruzi trypanosomiasis vector control Adult Aged Animals Animals, Domestic Animals, Wild Argentina Cat Diseases Cats Chagas Disease Dog Diseases Dogs Feces Female Humans Male Middle Aged Molecular Epidemiology Rural Health Triatoma Trypanosoma cruzi Young Adult Argentina South America Canis familiaris Mammalia Triatoma infestans Trypanosoma cruzi
description	Genetic diversity of Trypanosoma cruzi populations and parasite transmission dynamics have been well documented throughout the Americas, but few studies have been conducted in the Gran Chaco ecoregion, one of the most highly endemic areas for Chagas disease, caused by T. cruzi. In this study, we assessed the distribution of T. cruzi lineages (identified by PCR strategies) in Triatoma infestans, domestic dogs, cats, humans and sylvatic mammals from two neighbouring rural areas with different histories of transmission and vector control in northern Argentina. Lineage II predominated amongst the 99 isolates characterised and lineage I amongst the six isolates obtained from sylvatic mammals. T. cruzi lineage IIe predominated in domestic habitats; it was found in 87% of 54 isolates from Tr. infestans, in 82% of 33 isolates from dogs, and in the four cats found infected. Domestic and sylvatic cycles overlapped in the study area in the late 1980s, when intense domestic transmission occurred, and still overlap marginally. The introduction of T. cruzi from sylvatic into domestic habitats is likely to occur very rarely in the current epidemiological context. The household distribution of T. cruzi lineages showed that Tr. infestans, dogs and cats from a given house compound shared the same parasite lineage in most cases. Based on molecular evidence, this result lends further support to the importance of dogs and cats as domestic reservoir hosts of T. cruzi. We believe that in Argentina, this is the first time that lineage IIc has been isolated from naturally infected domestic dogs and Tr. infestans. © 2008 Australian Society for Parasitology Inc.
format	JOUR
author	Cardinal, M.V. Lauricella, M.A. Ceballos, L.A. Lanati, L. Marcet, P.L. Levin, M.J. Kitron, U. Gürtler, R.E. Schijman, A.G.
author_facet	Cardinal, M.V. Lauricella, M.A. Ceballos, L.A. Lanati, L. Marcet, P.L. Levin, M.J. Kitron, U. Gürtler, R.E. Schijman, A.G.
author_sort	Cardinal, M.V.
title	Molecular epidemiology of domestic and sylvatic Trypanosoma cruzi infection in rural northwestern Argentina
title_short	Molecular epidemiology of domestic and sylvatic Trypanosoma cruzi infection in rural northwestern Argentina
title_full	Molecular epidemiology of domestic and sylvatic Trypanosoma cruzi infection in rural northwestern Argentina
title_fullStr	Molecular epidemiology of domestic and sylvatic Trypanosoma cruzi infection in rural northwestern Argentina
title_full_unstemmed	Molecular epidemiology of domestic and sylvatic Trypanosoma cruzi infection in rural northwestern Argentina
title_sort	molecular epidemiology of domestic and sylvatic trypanosoma cruzi infection in rural northwestern argentina
url	http://hdl.handle.net/20.500.12110/paper_00207519_v38_n13_p1533_Cardinal
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Molecular epidemiology of domestic and sylvatic Trypanosoma cruzi infection in rural northwestern Argentina

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