Beneficial effect of S-adenosyl-l-methionine in lead intoxication. Another approach to clinical therapy

1. 1. Five patients with chronic lead intoxication were treated with S-adenosyl-l-methionine (12 mg/kg body weight, daily), given intravenously, over a period of 22 days. 2. 2. A significant recovery of erythrocytic ALA-D was observed in all cases, after therapy. 3. 3. Blood lead content significant...

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Autores principales: Paredes, S.R., de Geralnik, A.A.J., Del C. Batlle, A.M., Conti, H.A.
Formato: JOUR
Materias:
glutathione
lead
porphobilinogen synthase
s adenosylmethionine
chelation
clinical article
drug therapy
human
intoxication
lead poisoning
therapy
Adult
Child
Child, Preschool
Erythrocytes
Female
gamma-Glutamyltransferase
Glutathione
Human
Hydroxymethylbilane Synthase
Lead
Lead Poisoning
Male
Porphobilinogen Synthase
Porphyrins
S-Adenosylmethionine
Support, Non-U.S. Gov't
Time Factors
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_0020711X_v17_n5_p625_Paredes
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_0020711X_v17_n5_p625_Paredes
record_format dspace
spelling todo:paper_0020711X_v17_n5_p625_Paredes2023-10-03T14:17:49Z Beneficial effect of S-adenosyl-l-methionine in lead intoxication. Another approach to clinical therapy Paredes, S.R. de Geralnik, A.A.J. Del C. Batlle, A.M. Conti, H.A. glutathione lead porphobilinogen synthase s adenosylmethionine chelation clinical article drug therapy human intoxication lead poisoning therapy Adult Child Child, Preschool Erythrocytes Female gamma-Glutamyltransferase Glutathione Human Hydroxymethylbilane Synthase Lead Lead Poisoning Male Porphobilinogen Synthase Porphyrins S-Adenosylmethionine Support, Non-U.S. Gov't Time Factors 1. 1. Five patients with chronic lead intoxication were treated with S-adenosyl-l-methionine (12 mg/kg body weight, daily), given intravenously, over a period of 22 days. 2. 2. A significant recovery of erythrocytic ALA-D was observed in all cases, after therapy. 3. 3. Blood lead content significantly pathologic at the beginning of SAM administration, rapidly decreased within 24-48 h of initiating treatment, reaching nearly control values at the end of the trial. 4. 4. A good correlation between recovery of ALA-D activity and decreased concentration of lead in RBC was found. 5. 5. GSH content in blood was diminished in lead poisoned patients, increasing to normal levels after SAM administration. 6. 6. Other biochemical parameters such as Deaminase activity in RBC, ALA, PBG, porphyrins and lead in urine and serum γ-GT were measured, showing no important deviations from control values before, during or after treatment. 7. 7. Both biochemical and clinical improvement was observed, indicating that SAM therapy is beneficial in the treatment of lead intoxication. No untoward signs were observed. 8. 8. The mechanism of action of SAM is not yet clear; however, a chelating effect could be excluded, and very likely its action can be attributed to glutathione availability. © 1985. Fil:Paredes, S.R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Del C. Batlle, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_0020711X_v17_n5_p625_Paredes
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic glutathione
lead
porphobilinogen synthase
s adenosylmethionine
chelation
clinical article
drug therapy
human
intoxication
lead poisoning
therapy
Adult
Child
Child, Preschool
Erythrocytes
Female
gamma-Glutamyltransferase
Glutathione
Human
Hydroxymethylbilane Synthase
Lead
Lead Poisoning
Male
Porphobilinogen Synthase
Porphyrins
S-Adenosylmethionine
Support, Non-U.S. Gov't
Time Factors
spellingShingle glutathione
lead
porphobilinogen synthase
s adenosylmethionine
chelation
clinical article
drug therapy
human
intoxication
lead poisoning
therapy
Adult
Child
Child, Preschool
Erythrocytes
Female
gamma-Glutamyltransferase
Glutathione
Human
Hydroxymethylbilane Synthase
Lead
Lead Poisoning
Male
Porphobilinogen Synthase
Porphyrins
S-Adenosylmethionine
Support, Non-U.S. Gov't
Time Factors
Paredes, S.R.
de Geralnik, A.A.J.
Del C. Batlle, A.M.
Conti, H.A.
Beneficial effect of S-adenosyl-l-methionine in lead intoxication. Another approach to clinical therapy
topic_facet glutathione
lead
porphobilinogen synthase
s adenosylmethionine
chelation
clinical article
drug therapy
human
intoxication
lead poisoning
therapy
Adult
Child
Child, Preschool
Erythrocytes
Female
gamma-Glutamyltransferase
Glutathione
Human
Hydroxymethylbilane Synthase
Lead
Lead Poisoning
Male
Porphobilinogen Synthase
Porphyrins
S-Adenosylmethionine
Support, Non-U.S. Gov't
Time Factors
description 1. 1. Five patients with chronic lead intoxication were treated with S-adenosyl-l-methionine (12 mg/kg body weight, daily), given intravenously, over a period of 22 days. 2. 2. A significant recovery of erythrocytic ALA-D was observed in all cases, after therapy. 3. 3. Blood lead content significantly pathologic at the beginning of SAM administration, rapidly decreased within 24-48 h of initiating treatment, reaching nearly control values at the end of the trial. 4. 4. A good correlation between recovery of ALA-D activity and decreased concentration of lead in RBC was found. 5. 5. GSH content in blood was diminished in lead poisoned patients, increasing to normal levels after SAM administration. 6. 6. Other biochemical parameters such as Deaminase activity in RBC, ALA, PBG, porphyrins and lead in urine and serum γ-GT were measured, showing no important deviations from control values before, during or after treatment. 7. 7. Both biochemical and clinical improvement was observed, indicating that SAM therapy is beneficial in the treatment of lead intoxication. No untoward signs were observed. 8. 8. The mechanism of action of SAM is not yet clear; however, a chelating effect could be excluded, and very likely its action can be attributed to glutathione availability. © 1985.
format JOUR
author Paredes, S.R.
de Geralnik, A.A.J.
Del C. Batlle, A.M.
Conti, H.A.
author_facet Paredes, S.R.
de Geralnik, A.A.J.
Del C. Batlle, A.M.
Conti, H.A.
author_sort Paredes, S.R.
title Beneficial effect of S-adenosyl-l-methionine in lead intoxication. Another approach to clinical therapy
title_short Beneficial effect of S-adenosyl-l-methionine in lead intoxication. Another approach to clinical therapy
title_full Beneficial effect of S-adenosyl-l-methionine in lead intoxication. Another approach to clinical therapy
title_fullStr Beneficial effect of S-adenosyl-l-methionine in lead intoxication. Another approach to clinical therapy
title_full_unstemmed Beneficial effect of S-adenosyl-l-methionine in lead intoxication. Another approach to clinical therapy
title_sort beneficial effect of s-adenosyl-l-methionine in lead intoxication. another approach to clinical therapy
url http://hdl.handle.net/20.500.12110/paper_0020711X_v17_n5_p625_Paredes
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AT delcbatlleam beneficialeffectofsadenosyllmethionineinleadintoxicationanotherapproachtoclinicaltherapy
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