Effect of chlorophenols on porphyrin metabolism in rats and chick embryo

1. 1. Studies were carried out in order to clarify if pentachlorophenol (PCP), one of the hexachlorobenzene (HCB) metabolites, produces disturbances similar to that of HCB in the porphyrin metabolism. PCP could be the drug through which the porphyrinogenic action of HCB is mediated. 2. 2. The action...

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Autores principales: De Calmanovici, R.W., De Viale, L.C.S.M.
Formato: JOUR
Materias:
enzyme
pentachlorophenol
porphyrin
animal experiment
chicken
drug intoxication
drug urine level
embryo
intoxication
kidney
liver
oral drug administration
porphyria
preliminary communication
rat
spleen
5-Aminolevulinate Synthetase
Aminolevulinic Acid
Animal
Chick Embryo
Chlorophenols
Female
Intestines
Kidney
Liver
Pentachlorophenol
Porphobilinogen
Porphyrins
Rats
Species Specificity
Spleen
Support, Non-U.S. Gov't
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_0020711X_v12_n5-6_p1039_DeCalmanovici
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_0020711X_v12_n5-6_p1039_DeCalmanovici
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spelling todo:paper_0020711X_v12_n5-6_p1039_DeCalmanovici2023-10-03T14:17:37Z Effect of chlorophenols on porphyrin metabolism in rats and chick embryo De Calmanovici, R.W. De Viale, L.C.S.M. enzyme pentachlorophenol porphyrin animal experiment chicken drug intoxication drug urine level embryo intoxication kidney liver oral drug administration porphyria preliminary communication rat spleen 5-Aminolevulinate Synthetase Aminolevulinic Acid Animal Chick Embryo Chlorophenols Female Intestines Kidney Liver Pentachlorophenol Porphobilinogen Porphyrins Rats Species Specificity Spleen Support, Non-U.S. Gov't 1. 1. Studies were carried out in order to clarify if pentachlorophenol (PCP), one of the hexachlorobenzene (HCB) metabolites, produces disturbances similar to that of HCB in the porphyrin metabolism. PCP could be the drug through which the porphyrinogenic action of HCB is mediated. 2. 2. The action of technical and purified PCP on (a) the urinary excretion of ALA, PBG and porphyrins, (b) porphyrin accumulation in several tissues, (c) the activity of hepatic ALA-synthetase and Uro'gen decarboxylase has been studied in rats. The effect of purified drug on the porphyrin content and activity of the first enzyme was also investigated in chick embryos. 3. 3. The results obtained with technical PCP indicate that it produces: (a) marked increases in the excretion levels: porphyrins ≫ PBG ≫ ALA, the excretion peaks being at approx 15-16 weeks of treatment; (b) porphyrin accumulation in spleen, kidney and liver, in this order and being very marked in the latter at 970 μg/g; (c) increased ALA-synthetase (2.5 times) and a remarkable decrease (98%) in the porphyrinogen carboxy-lyase. 4. 4. Purified PCP does not significantly modify the parameters studied in rats. However, it does raise the levels of porphyrins and the activity of ALA-synthetase in the liver of 17-day-old chick embryo. 5. 5. The results obtained would indicate that in rats, only technical PCP is able to produce a definite and similar porphyria to that of HCB, while the purified drug does not. So, PCP alone does not seem to play an important role in the production mechanism of HCB porphyria. © 1980. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_0020711X_v12_n5-6_p1039_DeCalmanovici
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic enzyme
pentachlorophenol
porphyrin
animal experiment
chicken
drug intoxication
drug urine level
embryo
intoxication
kidney
liver
oral drug administration
porphyria
preliminary communication
rat
spleen
5-Aminolevulinate Synthetase
Aminolevulinic Acid
Animal
Chick Embryo
Chlorophenols
Female
Intestines
Kidney
Liver
Pentachlorophenol
Porphobilinogen
Porphyrins
Rats
Species Specificity
Spleen
Support, Non-U.S. Gov't
spellingShingle enzyme
pentachlorophenol
porphyrin
animal experiment
chicken
drug intoxication
drug urine level
embryo
intoxication
kidney
liver
oral drug administration
porphyria
preliminary communication
rat
spleen
5-Aminolevulinate Synthetase
Aminolevulinic Acid
Animal
Chick Embryo
Chlorophenols
Female
Intestines
Kidney
Liver
Pentachlorophenol
Porphobilinogen
Porphyrins
Rats
Species Specificity
Spleen
Support, Non-U.S. Gov't
De Calmanovici, R.W.
De Viale, L.C.S.M.
Effect of chlorophenols on porphyrin metabolism in rats and chick embryo
topic_facet enzyme
pentachlorophenol
porphyrin
animal experiment
chicken
drug intoxication
drug urine level
embryo
intoxication
kidney
liver
oral drug administration
porphyria
preliminary communication
rat
spleen
5-Aminolevulinate Synthetase
Aminolevulinic Acid
Animal
Chick Embryo
Chlorophenols
Female
Intestines
Kidney
Liver
Pentachlorophenol
Porphobilinogen
Porphyrins
Rats
Species Specificity
Spleen
Support, Non-U.S. Gov't
description 1. 1. Studies were carried out in order to clarify if pentachlorophenol (PCP), one of the hexachlorobenzene (HCB) metabolites, produces disturbances similar to that of HCB in the porphyrin metabolism. PCP could be the drug through which the porphyrinogenic action of HCB is mediated. 2. 2. The action of technical and purified PCP on (a) the urinary excretion of ALA, PBG and porphyrins, (b) porphyrin accumulation in several tissues, (c) the activity of hepatic ALA-synthetase and Uro'gen decarboxylase has been studied in rats. The effect of purified drug on the porphyrin content and activity of the first enzyme was also investigated in chick embryos. 3. 3. The results obtained with technical PCP indicate that it produces: (a) marked increases in the excretion levels: porphyrins ≫ PBG ≫ ALA, the excretion peaks being at approx 15-16 weeks of treatment; (b) porphyrin accumulation in spleen, kidney and liver, in this order and being very marked in the latter at 970 μg/g; (c) increased ALA-synthetase (2.5 times) and a remarkable decrease (98%) in the porphyrinogen carboxy-lyase. 4. 4. Purified PCP does not significantly modify the parameters studied in rats. However, it does raise the levels of porphyrins and the activity of ALA-synthetase in the liver of 17-day-old chick embryo. 5. 5. The results obtained would indicate that in rats, only technical PCP is able to produce a definite and similar porphyria to that of HCB, while the purified drug does not. So, PCP alone does not seem to play an important role in the production mechanism of HCB porphyria. © 1980.
format JOUR
author De Calmanovici, R.W.
De Viale, L.C.S.M.
author_facet De Calmanovici, R.W.
De Viale, L.C.S.M.
author_sort De Calmanovici, R.W.
title Effect of chlorophenols on porphyrin metabolism in rats and chick embryo
title_short Effect of chlorophenols on porphyrin metabolism in rats and chick embryo
title_full Effect of chlorophenols on porphyrin metabolism in rats and chick embryo
title_fullStr Effect of chlorophenols on porphyrin metabolism in rats and chick embryo
title_full_unstemmed Effect of chlorophenols on porphyrin metabolism in rats and chick embryo
title_sort effect of chlorophenols on porphyrin metabolism in rats and chick embryo
url http://hdl.handle.net/20.500.12110/paper_0020711X_v12_n5-6_p1039_DeCalmanovici
work_keys_str_mv AT decalmanovicirw effectofchlorophenolsonporphyrinmetabolisminratsandchickembryo
AT devialelcsm effectofchlorophenolsonporphyrinmetabolisminratsandchickembryo
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