Design, synthesis, and anti‐ Trypanosoma cruzi evaluation of a new class of cell‐growth inhibitors structurally related to Fenoxycarb

Several compounds, structurally related to the insect‐growth regulator Fenoxycarb (1), were designed and synthesized. These compounds were tested as growth inhibitors of Trypanosoma cruzi cells (epimastigotes). Compounds 6, 16, 18, and 22 were very active against T. cruzi making them promising good...

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Autores principales:	Schvartzapel, A.J., Fichera, L., Esteva, M., Rodriguez, J.B., Gros, E.G.
Formato:	JOUR
Materias:	carbamic acid derivative fenoxycarb insecticide article drug activity drug design drug synthesis nonhuman nuclear magnetic resonance reaction analysis trypanosoma cruzi
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_0018019X_v78_n5_p1207_Schvartzapel
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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spelling	todo:paper_0018019X_v78_n5_p1207_Schvartzapel2023-10-03T14:15:05Z Design, synthesis, and anti‐ Trypanosoma cruzi evaluation of a new class of cell‐growth inhibitors structurally related to Fenoxycarb Schvartzapel, A.J. Fichera, L. Esteva, M. Rodriguez, J.B. Gros, E.G. carbamic acid derivative fenoxycarb insecticide article drug activity drug design drug synthesis nonhuman nuclear magnetic resonance reaction analysis trypanosoma cruzi Several compounds, structurally related to the insect‐growth regulator Fenoxycarb (1), were designed and synthesized. These compounds were tested as growth inhibitors of Trypanosoma cruzi cells (epimastigotes). Compounds 6, 16, 18, and 22 were very active against T. cruzi making them promising good candidates either for blood‐bank sterilization of Chagas'‐disease surveillance, while compounds 11, 12, 13, and 19 showed a moderate degree of activity. Copyright © 1995 Verlag GmbH & Co. KGaA, Weinheim Fil:Schvartzapel, A.J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Rodriguez, J.B. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Gros, E.G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_0018019X_v78_n5_p1207_Schvartzapel
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	carbamic acid derivative fenoxycarb insecticide article drug activity drug design drug synthesis nonhuman nuclear magnetic resonance reaction analysis trypanosoma cruzi
spellingShingle	carbamic acid derivative fenoxycarb insecticide article drug activity drug design drug synthesis nonhuman nuclear magnetic resonance reaction analysis trypanosoma cruzi Schvartzapel, A.J. Fichera, L. Esteva, M. Rodriguez, J.B. Gros, E.G. Design, synthesis, and anti‐ Trypanosoma cruzi evaluation of a new class of cell‐growth inhibitors structurally related to Fenoxycarb
topic_facet	carbamic acid derivative fenoxycarb insecticide article drug activity drug design drug synthesis nonhuman nuclear magnetic resonance reaction analysis trypanosoma cruzi
description	Several compounds, structurally related to the insect‐growth regulator Fenoxycarb (1), were designed and synthesized. These compounds were tested as growth inhibitors of Trypanosoma cruzi cells (epimastigotes). Compounds 6, 16, 18, and 22 were very active against T. cruzi making them promising good candidates either for blood‐bank sterilization of Chagas'‐disease surveillance, while compounds 11, 12, 13, and 19 showed a moderate degree of activity. Copyright © 1995 Verlag GmbH & Co. KGaA, Weinheim
format	JOUR
author	Schvartzapel, A.J. Fichera, L. Esteva, M. Rodriguez, J.B. Gros, E.G.
author_facet	Schvartzapel, A.J. Fichera, L. Esteva, M. Rodriguez, J.B. Gros, E.G.
author_sort	Schvartzapel, A.J.
title	Design, synthesis, and anti‐ Trypanosoma cruzi evaluation of a new class of cell‐growth inhibitors structurally related to Fenoxycarb
title_short	Design, synthesis, and anti‐ Trypanosoma cruzi evaluation of a new class of cell‐growth inhibitors structurally related to Fenoxycarb
title_full	Design, synthesis, and anti‐ Trypanosoma cruzi evaluation of a new class of cell‐growth inhibitors structurally related to Fenoxycarb
title_fullStr	Design, synthesis, and anti‐ Trypanosoma cruzi evaluation of a new class of cell‐growth inhibitors structurally related to Fenoxycarb
title_full_unstemmed	Design, synthesis, and anti‐ Trypanosoma cruzi evaluation of a new class of cell‐growth inhibitors structurally related to Fenoxycarb
title_sort	design, synthesis, and anti‐ trypanosoma cruzi evaluation of a new class of cell‐growth inhibitors structurally related to fenoxycarb
url	http://hdl.handle.net/20.500.12110/paper_0018019X_v78_n5_p1207_Schvartzapel
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Design, synthesis, and anti‐ Trypanosoma cruzi evaluation of a new class of cell‐growth inhibitors structurally related to Fenoxycarb

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