Contrasting histories of three gene regions associated with In(3L)Payne of Drosophila melanogaster

In the present report, we studied nucleotide variation in three gene regions of Drosophila melanogaster, spanning >5 kb and showing different degrees of association with the cosmopolitan inversion In(3L)Payne. The analysis of sequence variation in the regions surrounding the breakpoints and the h...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Hasson, E., Eanes, W.F.
Formato:	JOUR
Materias:	esterase heat shock protein article chromosome breakage chromosome inversion drosophila melanogaster gene rearrangement genetic variability nonhuman priority journal Animals Carboxylesterase Carboxylic Ester Hydrolases Drosophila melanogaster Drosophila Proteins Genes, Insect Heat-Shock Proteins Inversion, Chromosome Polymorphism, Genetic Protozoan Proteins Recombination, Genetic Melanogaster
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_00166731_v144_n4_p1565_Hasson
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_00166731_v144_n4_p1565_Hasson
record_format	dspace
spelling	todo:paper_00166731_v144_n4_p1565_Hasson2023-10-03T14:14:31Z Contrasting histories of three gene regions associated with In(3L)Payne of Drosophila melanogaster Hasson, E. Eanes, W.F. esterase heat shock protein article chromosome breakage chromosome inversion drosophila melanogaster gene rearrangement genetic variability nonhuman priority journal Animals Carboxylesterase Carboxylic Ester Hydrolases Drosophila melanogaster Drosophila Proteins Genes, Insect Heat-Shock Proteins Inversion, Chromosome Polymorphism, Genetic Protozoan Proteins Recombination, Genetic Drosophila melanogaster Melanogaster In the present report, we studied nucleotide variation in three gene regions of Drosophila melanogaster, spanning >5 kb and showing different degrees of association with the cosmopolitan inversion In(3L)Payne. The analysis of sequence variation in the regions surrounding the breakpoints and the heat shock 83 (Hsp83) gene locus, located close to the distal breakpoint, revealed the absence of shared polymorphisms and the presence of a number of fixed differences between arrangements, indicating absence of genetic exchange. In contrast, for the esterase-6 gene region, located in the center of the inversion, we observed the presence of shared polymorphisms between arrangements suggesting genetic exchange. In the regions close to the breakpoints, the common St arrangement is 10 times more polymorphic than inverted chromosomes. We propose that the lack of recombination between arrangements in these regions coupled with genetic hitchhiking is the best explanation for the low heterozygosity observed in inverted lines. Using the data for the breakpoints, we estimate that this inversion polymorphism is around 0.36 million yr old. Although it is widely accepted that inversions are examples of balanced polymorphisms, none of the current neutrality tests including our Monte Carlo simulations showed significant departure from neutral expectations. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00166731_v144_n4_p1565_Hasson
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	esterase heat shock protein article chromosome breakage chromosome inversion drosophila melanogaster gene rearrangement genetic variability nonhuman priority journal Animals Carboxylesterase Carboxylic Ester Hydrolases Drosophila melanogaster Drosophila Proteins Genes, Insect Heat-Shock Proteins Inversion, Chromosome Polymorphism, Genetic Protozoan Proteins Recombination, Genetic Drosophila melanogaster Melanogaster
spellingShingle	esterase heat shock protein article chromosome breakage chromosome inversion drosophila melanogaster gene rearrangement genetic variability nonhuman priority journal Animals Carboxylesterase Carboxylic Ester Hydrolases Drosophila melanogaster Drosophila Proteins Genes, Insect Heat-Shock Proteins Inversion, Chromosome Polymorphism, Genetic Protozoan Proteins Recombination, Genetic Drosophila melanogaster Melanogaster Hasson, E. Eanes, W.F. Contrasting histories of three gene regions associated with In(3L)Payne of Drosophila melanogaster
topic_facet	esterase heat shock protein article chromosome breakage chromosome inversion drosophila melanogaster gene rearrangement genetic variability nonhuman priority journal Animals Carboxylesterase Carboxylic Ester Hydrolases Drosophila melanogaster Drosophila Proteins Genes, Insect Heat-Shock Proteins Inversion, Chromosome Polymorphism, Genetic Protozoan Proteins Recombination, Genetic Drosophila melanogaster Melanogaster
description	In the present report, we studied nucleotide variation in three gene regions of Drosophila melanogaster, spanning >5 kb and showing different degrees of association with the cosmopolitan inversion In(3L)Payne. The analysis of sequence variation in the regions surrounding the breakpoints and the heat shock 83 (Hsp83) gene locus, located close to the distal breakpoint, revealed the absence of shared polymorphisms and the presence of a number of fixed differences between arrangements, indicating absence of genetic exchange. In contrast, for the esterase-6 gene region, located in the center of the inversion, we observed the presence of shared polymorphisms between arrangements suggesting genetic exchange. In the regions close to the breakpoints, the common St arrangement is 10 times more polymorphic than inverted chromosomes. We propose that the lack of recombination between arrangements in these regions coupled with genetic hitchhiking is the best explanation for the low heterozygosity observed in inverted lines. Using the data for the breakpoints, we estimate that this inversion polymorphism is around 0.36 million yr old. Although it is widely accepted that inversions are examples of balanced polymorphisms, none of the current neutrality tests including our Monte Carlo simulations showed significant departure from neutral expectations.
format	JOUR
author	Hasson, E. Eanes, W.F.
author_facet	Hasson, E. Eanes, W.F.
author_sort	Hasson, E.
title	Contrasting histories of three gene regions associated with In(3L)Payne of Drosophila melanogaster
title_short	Contrasting histories of three gene regions associated with In(3L)Payne of Drosophila melanogaster
title_full	Contrasting histories of three gene regions associated with In(3L)Payne of Drosophila melanogaster
title_fullStr	Contrasting histories of three gene regions associated with In(3L)Payne of Drosophila melanogaster
title_full_unstemmed	Contrasting histories of three gene regions associated with In(3L)Payne of Drosophila melanogaster
title_sort	contrasting histories of three gene regions associated with in(3l)payne of drosophila melanogaster
url	http://hdl.handle.net/20.500.12110/paper_00166731_v144_n4_p1565_Hasson
work_keys_str_mv	AT hassone contrastinghistoriesofthreegeneregionsassociatedwithin3lpayneofdrosophilamelanogaster AT eaneswf contrastinghistoriesofthreegeneregionsassociatedwithin3lpayneofdrosophilamelanogaster
_version_	1807317328993452032

Contrasting histories of three gene regions associated with In(3L)Payne of Drosophila melanogaster

Ejemplares similares