Oral contraceptives suppress cell proliferation and enhance apoptosis of eutopic endometrial tissue from patients with endometriosis
Objective: To evaluate the effects of administering combination oral contraceptives (COCs) to patients with endometriosis on the regulation of cell growth in the eutopic endometrium. Design: Prospective study. Setting: Research institute and clinical fertility center. Patient(s): Thirteen women with...
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todo:paper_00150282_v77_n6_p1141_Meresman2023-10-03T14:13:24Z Oral contraceptives suppress cell proliferation and enhance apoptosis of eutopic endometrial tissue from patients with endometriosis Meresman, G.F. Augé, L. Baraao, R.I. Lombardi, E. Tesone, M. Sueldo, C. Apoptosis Cell proliferation Endometriosis Eutopic endometrium Oral contraceptives deoxyuridinetriphosphate Ki 67 antigen oral contraceptive agent phosphate protein Bax protein bcl 2 unclassified drug apoptosis article cell assay cell growth cell proliferation clinical article clinical trial controlled clinical trial controlled study down regulation drug effect drug exposure endometriosis endometrium biopsy epithelium female growth regulation human immunohistochemistry nick end labeling priority journal prospective study protein analysis protein expression stroma Apoptosis bcl-2-Associated X Protein Cell Division Contraceptives, Oral Endometriosis Endometrium Epithelial Cells Female Humans Ki-67 Antigen Proto-Oncogene Proteins Proto-Oncogene Proteins c-bcl-2 Reference Values Stromal Cells Objective: To evaluate the effects of administering combination oral contraceptives (COCs) to patients with endometriosis on the regulation of cell growth in the eutopic endometrium. Design: Prospective study. Setting: Research institute and clinical fertility center. Patient(s): Thirteen women with untreated endometriosis and 13 controls. Intervention(s): Biopsy specimens of the eutopic endometrium were obtained from all subjects. Apoptosis, cell proliferation, and Bcl-2 and Bax expression were examined at the epithelial and stromal levels in the eutopic endometrium from patients with endometriosis before and after 30 days of daily exposure to COCs and from controls. Main Outcome Measure(s): Apoptotic cells were detected by using the dUTP nick-end labeling assay; Ki-67, Bcl-2, and Bax expressions were assessed by using immunohistochemical techniques. Result(s): After exposure to COCs, apoptosis was significantly increased in the eutopic endometrium compared with before COC administration, both at epithelial and stromal levels. Cell proliferation was significantly lowered by COCs. Conclusion(s): COCs showed a positive effect on patients with endometriosis by down-regulating cell proliferation and enhancing apoptosis in the eutopic endometrium. © 2002 by American Society for Reproductive Medicine. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00150282_v77_n6_p1141_Meresman |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
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R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Apoptosis Cell proliferation Endometriosis Eutopic endometrium Oral contraceptives deoxyuridinetriphosphate Ki 67 antigen oral contraceptive agent phosphate protein Bax protein bcl 2 unclassified drug apoptosis article cell assay cell growth cell proliferation clinical article clinical trial controlled clinical trial controlled study down regulation drug effect drug exposure endometriosis endometrium biopsy epithelium female growth regulation human immunohistochemistry nick end labeling priority journal prospective study protein analysis protein expression stroma Apoptosis bcl-2-Associated X Protein Cell Division Contraceptives, Oral Endometriosis Endometrium Epithelial Cells Female Humans Ki-67 Antigen Proto-Oncogene Proteins Proto-Oncogene Proteins c-bcl-2 Reference Values Stromal Cells |
| spellingShingle |
Apoptosis Cell proliferation Endometriosis Eutopic endometrium Oral contraceptives deoxyuridinetriphosphate Ki 67 antigen oral contraceptive agent phosphate protein Bax protein bcl 2 unclassified drug apoptosis article cell assay cell growth cell proliferation clinical article clinical trial controlled clinical trial controlled study down regulation drug effect drug exposure endometriosis endometrium biopsy epithelium female growth regulation human immunohistochemistry nick end labeling priority journal prospective study protein analysis protein expression stroma Apoptosis bcl-2-Associated X Protein Cell Division Contraceptives, Oral Endometriosis Endometrium Epithelial Cells Female Humans Ki-67 Antigen Proto-Oncogene Proteins Proto-Oncogene Proteins c-bcl-2 Reference Values Stromal Cells Meresman, G.F. Augé, L. Baraao, R.I. Lombardi, E. Tesone, M. Sueldo, C. Oral contraceptives suppress cell proliferation and enhance apoptosis of eutopic endometrial tissue from patients with endometriosis |
| topic_facet |
Apoptosis Cell proliferation Endometriosis Eutopic endometrium Oral contraceptives deoxyuridinetriphosphate Ki 67 antigen oral contraceptive agent phosphate protein Bax protein bcl 2 unclassified drug apoptosis article cell assay cell growth cell proliferation clinical article clinical trial controlled clinical trial controlled study down regulation drug effect drug exposure endometriosis endometrium biopsy epithelium female growth regulation human immunohistochemistry nick end labeling priority journal prospective study protein analysis protein expression stroma Apoptosis bcl-2-Associated X Protein Cell Division Contraceptives, Oral Endometriosis Endometrium Epithelial Cells Female Humans Ki-67 Antigen Proto-Oncogene Proteins Proto-Oncogene Proteins c-bcl-2 Reference Values Stromal Cells |
| description |
Objective: To evaluate the effects of administering combination oral contraceptives (COCs) to patients with endometriosis on the regulation of cell growth in the eutopic endometrium. Design: Prospective study. Setting: Research institute and clinical fertility center. Patient(s): Thirteen women with untreated endometriosis and 13 controls. Intervention(s): Biopsy specimens of the eutopic endometrium were obtained from all subjects. Apoptosis, cell proliferation, and Bcl-2 and Bax expression were examined at the epithelial and stromal levels in the eutopic endometrium from patients with endometriosis before and after 30 days of daily exposure to COCs and from controls. Main Outcome Measure(s): Apoptotic cells were detected by using the dUTP nick-end labeling assay; Ki-67, Bcl-2, and Bax expressions were assessed by using immunohistochemical techniques. Result(s): After exposure to COCs, apoptosis was significantly increased in the eutopic endometrium compared with before COC administration, both at epithelial and stromal levels. Cell proliferation was significantly lowered by COCs. Conclusion(s): COCs showed a positive effect on patients with endometriosis by down-regulating cell proliferation and enhancing apoptosis in the eutopic endometrium. © 2002 by American Society for Reproductive Medicine. |
| format |
JOUR |
| author |
Meresman, G.F. Augé, L. Baraao, R.I. Lombardi, E. Tesone, M. Sueldo, C. |
| author_facet |
Meresman, G.F. Augé, L. Baraao, R.I. Lombardi, E. Tesone, M. Sueldo, C. |
| author_sort |
Meresman, G.F. |
| title |
Oral contraceptives suppress cell proliferation and enhance apoptosis of eutopic endometrial tissue from patients with endometriosis |
| title_short |
Oral contraceptives suppress cell proliferation and enhance apoptosis of eutopic endometrial tissue from patients with endometriosis |
| title_full |
Oral contraceptives suppress cell proliferation and enhance apoptosis of eutopic endometrial tissue from patients with endometriosis |
| title_fullStr |
Oral contraceptives suppress cell proliferation and enhance apoptosis of eutopic endometrial tissue from patients with endometriosis |
| title_full_unstemmed |
Oral contraceptives suppress cell proliferation and enhance apoptosis of eutopic endometrial tissue from patients with endometriosis |
| title_sort |
oral contraceptives suppress cell proliferation and enhance apoptosis of eutopic endometrial tissue from patients with endometriosis |
| url |
http://hdl.handle.net/20.500.12110/paper_00150282_v77_n6_p1141_Meresman |
| work_keys_str_mv |
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1782026730929651712 |