Physiologic and pharmacologic studies on the motility of isolated guinea pig cauda epididymidis

The effects of norepinephrine, phentolamine, oxytocin, vasopressin, several prostaglandins, and indomethacin on the spontaneous motility of isolated guinea pig cauda epididymidis were explored. Phentolamine and indomethacin reduced the isometric peak tension of spontaneous epididymal contractions. P...

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Autores principales:	Da Silva Souza, E.M.C., Gimeno, M.F., Gimeno, A.L.
Formato:	JOUR
Materias:	indometacin noradrenalin oxytocin phentolamine phentolamine mesylate prostaglandin prostaglandin E1 prostaglandin E2 prostaglandin F2 alpha vasopressin epididymis guinea pig in vitro study smooth muscle contractility smooth muscle contraction theoretical study
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_00150282_v26_n12_p1250_DaSilvaSouza
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_00150282_v26_n12_p1250_DaSilvaSouza
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spelling	todo:paper_00150282_v26_n12_p1250_DaSilvaSouza2023-10-03T14:13:22Z Physiologic and pharmacologic studies on the motility of isolated guinea pig cauda epididymidis Da Silva Souza, E.M.C. Gimeno, M.F. Gimeno, A.L. indometacin noradrenalin oxytocin phentolamine phentolamine mesylate prostaglandin prostaglandin E1 prostaglandin E2 prostaglandin F2 alpha vasopressin epididymis guinea pig in vitro study smooth muscle contractility smooth muscle contraction theoretical study The effects of norepinephrine, phentolamine, oxytocin, vasopressin, several prostaglandins, and indomethacin on the spontaneous motility of isolated guinea pig cauda epididymidis were explored. Phentolamine and indomethacin reduced the isometric peak tension of spontaneous epididymal contractions. Phentolamine also depressed the frequency. Both findings suggest that catecholamines and endogenous prostaglandins are in some way regulators of the spontaneous motility of the cauda epididymidis. Norepinephrine resulted in the development of a distinct, sustained, tonic contraction without plastic activity, whereas prostaglandins E1, E2, and F(2α) elicited a tonic increase accompanied by frequent, superimposed, phasic contractions. Both oxytocin and vasopressin comparably enhanced epididymal motility, producing contractile responses similar to those observed with prostaglandins. Since the epididymal contractions can influence the time spent by spermatozoa in passing through the ductus epididymidis, the above mentioned compounds could play an important role in spermatozoal transport via modulation of epididymal contractile activity. In addition, such naturally occurring substances might regulate the release of sperm from the last portion of the epididymis into the ductus deferens. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00150282_v26_n12_p1250_DaSilvaSouza
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	indometacin noradrenalin oxytocin phentolamine phentolamine mesylate prostaglandin prostaglandin E1 prostaglandin E2 prostaglandin F2 alpha vasopressin epididymis guinea pig in vitro study smooth muscle contractility smooth muscle contraction theoretical study
spellingShingle	indometacin noradrenalin oxytocin phentolamine phentolamine mesylate prostaglandin prostaglandin E1 prostaglandin E2 prostaglandin F2 alpha vasopressin epididymis guinea pig in vitro study smooth muscle contractility smooth muscle contraction theoretical study Da Silva Souza, E.M.C. Gimeno, M.F. Gimeno, A.L. Physiologic and pharmacologic studies on the motility of isolated guinea pig cauda epididymidis
topic_facet	indometacin noradrenalin oxytocin phentolamine phentolamine mesylate prostaglandin prostaglandin E1 prostaglandin E2 prostaglandin F2 alpha vasopressin epididymis guinea pig in vitro study smooth muscle contractility smooth muscle contraction theoretical study
description	The effects of norepinephrine, phentolamine, oxytocin, vasopressin, several prostaglandins, and indomethacin on the spontaneous motility of isolated guinea pig cauda epididymidis were explored. Phentolamine and indomethacin reduced the isometric peak tension of spontaneous epididymal contractions. Phentolamine also depressed the frequency. Both findings suggest that catecholamines and endogenous prostaglandins are in some way regulators of the spontaneous motility of the cauda epididymidis. Norepinephrine resulted in the development of a distinct, sustained, tonic contraction without plastic activity, whereas prostaglandins E1, E2, and F(2α) elicited a tonic increase accompanied by frequent, superimposed, phasic contractions. Both oxytocin and vasopressin comparably enhanced epididymal motility, producing contractile responses similar to those observed with prostaglandins. Since the epididymal contractions can influence the time spent by spermatozoa in passing through the ductus epididymidis, the above mentioned compounds could play an important role in spermatozoal transport via modulation of epididymal contractile activity. In addition, such naturally occurring substances might regulate the release of sperm from the last portion of the epididymis into the ductus deferens.
format	JOUR
author	Da Silva Souza, E.M.C. Gimeno, M.F. Gimeno, A.L.
author_facet	Da Silva Souza, E.M.C. Gimeno, M.F. Gimeno, A.L.
author_sort	Da Silva Souza, E.M.C.
title	Physiologic and pharmacologic studies on the motility of isolated guinea pig cauda epididymidis
title_short	Physiologic and pharmacologic studies on the motility of isolated guinea pig cauda epididymidis
title_full	Physiologic and pharmacologic studies on the motility of isolated guinea pig cauda epididymidis
title_fullStr	Physiologic and pharmacologic studies on the motility of isolated guinea pig cauda epididymidis
title_full_unstemmed	Physiologic and pharmacologic studies on the motility of isolated guinea pig cauda epididymidis
title_sort	physiologic and pharmacologic studies on the motility of isolated guinea pig cauda epididymidis
url	http://hdl.handle.net/20.500.12110/paper_00150282_v26_n12_p1250_DaSilvaSouza
work_keys_str_mv	AT dasilvasouzaemc physiologicandpharmacologicstudiesonthemotilityofisolatedguineapigcaudaepididymidis AT gimenomf physiologicandpharmacologicstudiesonthemotilityofisolatedguineapigcaudaepididymidis AT gimenoal physiologicandpharmacologicstudiesonthemotilityofisolatedguineapigcaudaepididymidis
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Physiologic and pharmacologic studies on the motility of isolated guinea pig cauda epididymidis

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