Transforming growth factor β1, insulin and prostaglandin E1 enhance prostaglandin F2α mitogenic action in Swiss 3T3 cells via separate events

Transforming growth factor β1 (TGFβ1) had no mitogenic effect in Swiss 3T3 cells, but could increase prostaglandin F2α (PGF2α)-induced DNA synthesis. Insulin, but not prostaglandin E1 (PGE1), further enhanced PGF2α action at low TGFβ1 concentrations. TGFβ1 also acted concertedly with the protein kin...

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Autores principales:	de Alzaga, M.G., Goin, M., Ortiz, M., de Asua, L.J.
Formato:	JOUR
Materias:	DNA synthesis Insulin Protein kinase C TGFβ1 glycerol 2 acetate 1 oleate insulin prostaglandin e1 prostaglandin f2 alpha protein kinase c transforming growth factor beta1 animal cell article controlled study dna synthesis mitogenesis mouse nonhuman priority journal signal transduction 3T3 Cells Alprostadil Animal Cell Division Dinoprost DNA Mice Mitogens Signal Transduction Support, Non-U.S. Gov't Transforming Growth Factor beta
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_00145793_v356_n1_p21_deAlzaga
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_00145793_v356_n1_p21_deAlzaga
record_format	dspace
spelling	todo:paper_00145793_v356_n1_p21_deAlzaga2023-10-03T14:13:04Z Transforming growth factor β1, insulin and prostaglandin E1 enhance prostaglandin F2α mitogenic action in Swiss 3T3 cells via separate events de Alzaga, M.G. Goin, M. Ortiz, M. de Asua, L.J. DNA synthesis Insulin Protein kinase C TGFβ1 glycerol 2 acetate 1 oleate insulin prostaglandin e1 prostaglandin f2 alpha protein kinase c transforming growth factor beta1 animal cell article controlled study dna synthesis mitogenesis mouse nonhuman priority journal signal transduction 3T3 Cells Alprostadil Animal Cell Division Dinoprost DNA Insulin Mice Mitogens Signal Transduction Support, Non-U.S. Gov't Transforming Growth Factor beta Transforming growth factor β1 (TGFβ1) had no mitogenic effect in Swiss 3T3 cells, but could increase prostaglandin F2α (PGF2α)-induced DNA synthesis. Insulin, but not prostaglandin E1 (PGE1), further enhanced PGF2α action at low TGFβ1 concentrations. TGFβ1 also acted concertedly with the protein kinase C (PKC) activator 1-oleoyl-2-acetylglycerol to induce mitogenesis. Thus, it appears that TGFβ1 and insulin act via separate signals, while TGFβ1 and PGE1 might share a common pathway not involving TGFβ1-mediated prostaglandin synthesis. These results suggest that TGFβ1 might elicit various signalling mechanisms to enhance PGF2α-triggered events. © 1994. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00145793_v356_n1_p21_deAlzaga
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	DNA synthesis Insulin Protein kinase C TGFβ1 glycerol 2 acetate 1 oleate insulin prostaglandin e1 prostaglandin f2 alpha protein kinase c transforming growth factor beta1 animal cell article controlled study dna synthesis mitogenesis mouse nonhuman priority journal signal transduction 3T3 Cells Alprostadil Animal Cell Division Dinoprost DNA Insulin Mice Mitogens Signal Transduction Support, Non-U.S. Gov't Transforming Growth Factor beta
spellingShingle	DNA synthesis Insulin Protein kinase C TGFβ1 glycerol 2 acetate 1 oleate insulin prostaglandin e1 prostaglandin f2 alpha protein kinase c transforming growth factor beta1 animal cell article controlled study dna synthesis mitogenesis mouse nonhuman priority journal signal transduction 3T3 Cells Alprostadil Animal Cell Division Dinoprost DNA Insulin Mice Mitogens Signal Transduction Support, Non-U.S. Gov't Transforming Growth Factor beta de Alzaga, M.G. Goin, M. Ortiz, M. de Asua, L.J. Transforming growth factor β1, insulin and prostaglandin E1 enhance prostaglandin F2α mitogenic action in Swiss 3T3 cells via separate events
topic_facet	DNA synthesis Insulin Protein kinase C TGFβ1 glycerol 2 acetate 1 oleate insulin prostaglandin e1 prostaglandin f2 alpha protein kinase c transforming growth factor beta1 animal cell article controlled study dna synthesis mitogenesis mouse nonhuman priority journal signal transduction 3T3 Cells Alprostadil Animal Cell Division Dinoprost DNA Insulin Mice Mitogens Signal Transduction Support, Non-U.S. Gov't Transforming Growth Factor beta
description	Transforming growth factor β1 (TGFβ1) had no mitogenic effect in Swiss 3T3 cells, but could increase prostaglandin F2α (PGF2α)-induced DNA synthesis. Insulin, but not prostaglandin E1 (PGE1), further enhanced PGF2α action at low TGFβ1 concentrations. TGFβ1 also acted concertedly with the protein kinase C (PKC) activator 1-oleoyl-2-acetylglycerol to induce mitogenesis. Thus, it appears that TGFβ1 and insulin act via separate signals, while TGFβ1 and PGE1 might share a common pathway not involving TGFβ1-mediated prostaglandin synthesis. These results suggest that TGFβ1 might elicit various signalling mechanisms to enhance PGF2α-triggered events. © 1994.
format	JOUR
author	de Alzaga, M.G. Goin, M. Ortiz, M. de Asua, L.J.
author_facet	de Alzaga, M.G. Goin, M. Ortiz, M. de Asua, L.J.
author_sort	de Alzaga, M.G.
title	Transforming growth factor β1, insulin and prostaglandin E1 enhance prostaglandin F2α mitogenic action in Swiss 3T3 cells via separate events
title_short	Transforming growth factor β1, insulin and prostaglandin E1 enhance prostaglandin F2α mitogenic action in Swiss 3T3 cells via separate events
title_full	Transforming growth factor β1, insulin and prostaglandin E1 enhance prostaglandin F2α mitogenic action in Swiss 3T3 cells via separate events
title_fullStr	Transforming growth factor β1, insulin and prostaglandin E1 enhance prostaglandin F2α mitogenic action in Swiss 3T3 cells via separate events
title_full_unstemmed	Transforming growth factor β1, insulin and prostaglandin E1 enhance prostaglandin F2α mitogenic action in Swiss 3T3 cells via separate events
title_sort	transforming growth factor β1, insulin and prostaglandin e1 enhance prostaglandin f2α mitogenic action in swiss 3t3 cells via separate events
url	http://hdl.handle.net/20.500.12110/paper_00145793_v356_n1_p21_deAlzaga
work_keys_str_mv	AT dealzagamg transforminggrowthfactorb1insulinandprostaglandine1enhanceprostaglandinf2amitogenicactioninswiss3t3cellsviaseparateevents AT goinm transforminggrowthfactorb1insulinandprostaglandine1enhanceprostaglandinf2amitogenicactioninswiss3t3cellsviaseparateevents AT ortizm transforminggrowthfactorb1insulinandprostaglandine1enhanceprostaglandinf2amitogenicactioninswiss3t3cellsviaseparateevents AT deasualj transforminggrowthfactorb1insulinandprostaglandine1enhanceprostaglandinf2amitogenicactioninswiss3t3cellsviaseparateevents
_version_	1807324405034909696

Transforming growth factor β1, insulin and prostaglandin E1 enhance prostaglandin F2α mitogenic action in Swiss 3T3 cells via separate events

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