Induction of trypanosoma cruzi metacyclogenesis in the gut of the hematophagous insect vector, rhodnius prolixus, by hemoglobin and peptides carrying αD-globin sequences

Trypanosoma cruzi, a protozoan responsible for the American trypanosomiasis (Chagas disease), multiplies and differentiates in the gut of triatomine insect vectors. The effects of hemoglobin and synthetic peptides carrying αD-globin fragments on both the growth and the transformation of T. cruzi epi...

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Autores principales: Garcia, E.S., Gonzalez, M.S., De Azambuja, P., Baralle, F.E., Fraidenraich, D., Torres, H.N., Flawia, M.M.
Formato: JOUR
Materias:
hemoglobin
peptide
synthetic peptide
amino acid sequence
article
chagas disease
epimastigote
nonhuman
priority journal
trypanosoma cruzi
trypomastigote
Amino Acid Sequence
Animals
Globins
Hemoglobins
Insect Vectors
Larva
Molecular Sequence Data
Rhodnius
Trypanosoma cruzi
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00144894_v81_n3_p255_Garcia
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
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spelling todo:paper_00144894_v81_n3_p255_Garcia2023-10-03T14:12:48Z Induction of trypanosoma cruzi metacyclogenesis in the gut of the hematophagous insect vector, rhodnius prolixus, by hemoglobin and peptides carrying αD-globin sequences Garcia, E.S. Gonzalez, M.S. De Azambuja, P. Baralle, F.E. Fraidenraich, D. Torres, H.N. Flawia, M.M. hemoglobin peptide synthetic peptide amino acid sequence article chagas disease epimastigote nonhuman priority journal trypanosoma cruzi trypomastigote Amino Acid Sequence Animals Globins Hemoglobins Insect Vectors Larva Molecular Sequence Data Rhodnius Trypanosoma cruzi Trypanosoma cruzi, a protozoan responsible for the American trypanosomiasis (Chagas disease), multiplies and differentiates in the gut of triatomine insect vectors. The effects of hemoglobin and synthetic peptides carrying αD-globin fragments on both the growth and the transformation of T. cruzi epimastigotes (noninfective) into metacyclic trypomastigotes (infective forms) were studied. This differentiation in the insect′s gut is expressed when hemoglobin and synthetic peptides corresponding to residues 30-49 and 35-73 of the αD-globin were added to the plasma diet. However, synthetic peptide 41-73 does not induce differentiation of epimastigotes even in the presence of the two former synthetic peptides. Thus, these data delineate an unusual molecular mechanism which modulates the dynamics of transformation of epimastigotes into metacyclic trypomastigotes in the triatomine vector′s gut. © 1995 Academic press, Inc. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00144894_v81_n3_p255_Garcia
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic hemoglobin
peptide
synthetic peptide
amino acid sequence
article
chagas disease
epimastigote
nonhuman
priority journal
trypanosoma cruzi
trypomastigote
Amino Acid Sequence
Animals
Globins
Hemoglobins
Insect Vectors
Larva
Molecular Sequence Data
Rhodnius
Trypanosoma cruzi
spellingShingle hemoglobin
peptide
synthetic peptide
amino acid sequence
article
chagas disease
epimastigote
nonhuman
priority journal
trypanosoma cruzi
trypomastigote
Amino Acid Sequence
Animals
Globins
Hemoglobins
Insect Vectors
Larva
Molecular Sequence Data
Rhodnius
Trypanosoma cruzi
Garcia, E.S.
Gonzalez, M.S.
De Azambuja, P.
Baralle, F.E.
Fraidenraich, D.
Torres, H.N.
Flawia, M.M.
Induction of trypanosoma cruzi metacyclogenesis in the gut of the hematophagous insect vector, rhodnius prolixus, by hemoglobin and peptides carrying αD-globin sequences
topic_facet hemoglobin
peptide
synthetic peptide
amino acid sequence
article
chagas disease
epimastigote
nonhuman
priority journal
trypanosoma cruzi
trypomastigote
Amino Acid Sequence
Animals
Globins
Hemoglobins
Insect Vectors
Larva
Molecular Sequence Data
Rhodnius
Trypanosoma cruzi
description Trypanosoma cruzi, a protozoan responsible for the American trypanosomiasis (Chagas disease), multiplies and differentiates in the gut of triatomine insect vectors. The effects of hemoglobin and synthetic peptides carrying αD-globin fragments on both the growth and the transformation of T. cruzi epimastigotes (noninfective) into metacyclic trypomastigotes (infective forms) were studied. This differentiation in the insect′s gut is expressed when hemoglobin and synthetic peptides corresponding to residues 30-49 and 35-73 of the αD-globin were added to the plasma diet. However, synthetic peptide 41-73 does not induce differentiation of epimastigotes even in the presence of the two former synthetic peptides. Thus, these data delineate an unusual molecular mechanism which modulates the dynamics of transformation of epimastigotes into metacyclic trypomastigotes in the triatomine vector′s gut. © 1995 Academic press, Inc.
format JOUR
author Garcia, E.S.
Gonzalez, M.S.
De Azambuja, P.
Baralle, F.E.
Fraidenraich, D.
Torres, H.N.
Flawia, M.M.
author_facet Garcia, E.S.
Gonzalez, M.S.
De Azambuja, P.
Baralle, F.E.
Fraidenraich, D.
Torres, H.N.
Flawia, M.M.
author_sort Garcia, E.S.
title Induction of trypanosoma cruzi metacyclogenesis in the gut of the hematophagous insect vector, rhodnius prolixus, by hemoglobin and peptides carrying αD-globin sequences
title_short Induction of trypanosoma cruzi metacyclogenesis in the gut of the hematophagous insect vector, rhodnius prolixus, by hemoglobin and peptides carrying αD-globin sequences
title_full Induction of trypanosoma cruzi metacyclogenesis in the gut of the hematophagous insect vector, rhodnius prolixus, by hemoglobin and peptides carrying αD-globin sequences
title_fullStr Induction of trypanosoma cruzi metacyclogenesis in the gut of the hematophagous insect vector, rhodnius prolixus, by hemoglobin and peptides carrying αD-globin sequences
title_full_unstemmed Induction of trypanosoma cruzi metacyclogenesis in the gut of the hematophagous insect vector, rhodnius prolixus, by hemoglobin and peptides carrying αD-globin sequences
title_sort induction of trypanosoma cruzi metacyclogenesis in the gut of the hematophagous insect vector, rhodnius prolixus, by hemoglobin and peptides carrying αd-globin sequences
url http://hdl.handle.net/20.500.12110/paper_00144894_v81_n3_p255_Garcia
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