Mechanisms of coronary vasoconstriction induced by Na arachidonate in experimentally diabetic dogs

Na arachidonate (NaA) enhanced the resting basal tone of isolated coronary arteries from diabetic dogs and depressed it in coronary arteries from normal controls. Inhibitors of thromboxane A2 biosynthesis and of lipoxygenases abolished the vasoconstrictor effect of NaA on diabetic arteries, whereas...

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Autores principales: Sterin-Borda, L., Borda, E., del Castillo, E.J., Gimeno, M.F., Gimeno, A.L.
Formato: JOUR
Materias:
5,8,11,14 icosatetraynoic acid
acetylsalicylic acid
arachidonic acid
imidazole
indometacin
nordihydroguaiaretic acid
tranylcypromine
animal experiment
cardiovascular system
coronary artery
diabetes mellitus
dog
endocrine system
heart
vasoconstriction
Animals
Arachidonic Acids
Arteries
Coronary Vessels
Cyclooxygenase Inhibitors
Diabetes Mellitus, Experimental
Dogs
Dose-Response Relationship, Drug
Epoprostenol
Lipoxygenase Inhibitors
Pancreatectomy
Thromboxane A2
Vasoconstriction
Animalia
Canis familiaris
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00144754_v38_n7_p835_SterinBorda
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_00144754_v38_n7_p835_SterinBorda
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spelling todo:paper_00144754_v38_n7_p835_SterinBorda2023-10-03T14:12:28Z Mechanisms of coronary vasoconstriction induced by Na arachidonate in experimentally diabetic dogs Sterin-Borda, L. Borda, E. del Castillo, E.J. Gimeno, M.F. Gimeno, A.L. 5,8,11,14 icosatetraynoic acid acetylsalicylic acid arachidonic acid imidazole indometacin nordihydroguaiaretic acid tranylcypromine animal experiment cardiovascular system coronary artery diabetes mellitus dog endocrine system heart vasoconstriction Animals Arachidonic Acids Arteries Coronary Vessels Cyclooxygenase Inhibitors Diabetes Mellitus, Experimental Dogs Dose-Response Relationship, Drug Epoprostenol Lipoxygenase Inhibitors Pancreatectomy Thromboxane A2 Vasoconstriction Animalia Canis familiaris Na arachidonate (NaA) enhanced the resting basal tone of isolated coronary arteries from diabetic dogs and depressed it in coronary arteries from normal controls. Inhibitors of thromboxane A2 biosynthesis and of lipoxygenases abolished the vasoconstrictor effect of NaA on diabetic arteries, whereas inhibitors of cyclooxygenase activity and PGI2 biosynthesis blocked the vasodilating action of NaA on normal arteries. © 1982 Birkhäuser Verlag. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00144754_v38_n7_p835_SterinBorda
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic 5,8,11,14 icosatetraynoic acid
acetylsalicylic acid
arachidonic acid
imidazole
indometacin
nordihydroguaiaretic acid
tranylcypromine
animal experiment
cardiovascular system
coronary artery
diabetes mellitus
dog
endocrine system
heart
vasoconstriction
Animals
Arachidonic Acids
Arteries
Coronary Vessels
Cyclooxygenase Inhibitors
Diabetes Mellitus, Experimental
Dogs
Dose-Response Relationship, Drug
Epoprostenol
Lipoxygenase Inhibitors
Pancreatectomy
Thromboxane A2
Vasoconstriction
Animalia
Canis familiaris
spellingShingle 5,8,11,14 icosatetraynoic acid
acetylsalicylic acid
arachidonic acid
imidazole
indometacin
nordihydroguaiaretic acid
tranylcypromine
animal experiment
cardiovascular system
coronary artery
diabetes mellitus
dog
endocrine system
heart
vasoconstriction
Animals
Arachidonic Acids
Arteries
Coronary Vessels
Cyclooxygenase Inhibitors
Diabetes Mellitus, Experimental
Dogs
Dose-Response Relationship, Drug
Epoprostenol
Lipoxygenase Inhibitors
Pancreatectomy
Thromboxane A2
Vasoconstriction
Animalia
Canis familiaris
Sterin-Borda, L.
Borda, E.
del Castillo, E.J.
Gimeno, M.F.
Gimeno, A.L.
Mechanisms of coronary vasoconstriction induced by Na arachidonate in experimentally diabetic dogs
topic_facet 5,8,11,14 icosatetraynoic acid
acetylsalicylic acid
arachidonic acid
imidazole
indometacin
nordihydroguaiaretic acid
tranylcypromine
animal experiment
cardiovascular system
coronary artery
diabetes mellitus
dog
endocrine system
heart
vasoconstriction
Animals
Arachidonic Acids
Arteries
Coronary Vessels
Cyclooxygenase Inhibitors
Diabetes Mellitus, Experimental
Dogs
Dose-Response Relationship, Drug
Epoprostenol
Lipoxygenase Inhibitors
Pancreatectomy
Thromboxane A2
Vasoconstriction
Animalia
Canis familiaris
description Na arachidonate (NaA) enhanced the resting basal tone of isolated coronary arteries from diabetic dogs and depressed it in coronary arteries from normal controls. Inhibitors of thromboxane A2 biosynthesis and of lipoxygenases abolished the vasoconstrictor effect of NaA on diabetic arteries, whereas inhibitors of cyclooxygenase activity and PGI2 biosynthesis blocked the vasodilating action of NaA on normal arteries. © 1982 Birkhäuser Verlag.
format JOUR
author Sterin-Borda, L.
Borda, E.
del Castillo, E.J.
Gimeno, M.F.
Gimeno, A.L.
author_facet Sterin-Borda, L.
Borda, E.
del Castillo, E.J.
Gimeno, M.F.
Gimeno, A.L.
author_sort Sterin-Borda, L.
title Mechanisms of coronary vasoconstriction induced by Na arachidonate in experimentally diabetic dogs
title_short Mechanisms of coronary vasoconstriction induced by Na arachidonate in experimentally diabetic dogs
title_full Mechanisms of coronary vasoconstriction induced by Na arachidonate in experimentally diabetic dogs
title_fullStr Mechanisms of coronary vasoconstriction induced by Na arachidonate in experimentally diabetic dogs
title_full_unstemmed Mechanisms of coronary vasoconstriction induced by Na arachidonate in experimentally diabetic dogs
title_sort mechanisms of coronary vasoconstriction induced by na arachidonate in experimentally diabetic dogs
url http://hdl.handle.net/20.500.12110/paper_00144754_v38_n7_p835_SterinBorda
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AT bordae mechanismsofcoronaryvasoconstrictioninducedbynaarachidonateinexperimentallydiabeticdogs
AT delcastilloej mechanismsofcoronaryvasoconstrictioninducedbynaarachidonateinexperimentallydiabeticdogs
AT gimenomf mechanismsofcoronaryvasoconstrictioninducedbynaarachidonateinexperimentallydiabeticdogs
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