A biphasic effect of estradiol on serotonin metabolism in rat pineal organ cultures

Physiological amounts of estradiol (1 nM) significantly increased serotonin, conversion to melatonin and 5-methoxytryptophol by rat pineal glands in organ culture whereas larger, pharmacological, doses (i.e. 1000 nM) impaired it significantly. The stimulatory but not the inhibitory effect of estradi...

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Autores principales: Cardinali, D.P., Vacas, M.I., Ritta, M.N.
Formato: JOUR
Materias:
5 methoxytryptophol
estradiol
melatonin
puromycin
radioisotope
serotonin
animal experiment
drug metabolism
endocrine system
in vitro study
organ culture
pineal body
rat
Animal
Dose-Response Relationship, Drug
Estradiol
Organ Culture
Pineal Gland
Puromycin
Rats
Serotonin
Support, Non-U.S. Gov't
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00144754_v37_n2_p203_Cardinali
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_00144754_v37_n2_p203_Cardinali
record_format dspace
spelling todo:paper_00144754_v37_n2_p203_Cardinali2023-10-03T14:12:26Z A biphasic effect of estradiol on serotonin metabolism in rat pineal organ cultures Cardinali, D.P. Vacas, M.I. Ritta, M.N. 5 methoxytryptophol estradiol melatonin puromycin radioisotope serotonin animal experiment drug metabolism endocrine system in vitro study organ culture pineal body rat Animal Dose-Response Relationship, Drug Estradiol Organ Culture Pineal Gland Puromycin Rats Serotonin Support, Non-U.S. Gov't Physiological amounts of estradiol (1 nM) significantly increased serotonin, conversion to melatonin and 5-methoxytryptophol by rat pineal glands in organ culture whereas larger, pharmacological, doses (i.e. 1000 nM) impaired it significantly. The stimulatory but not the inhibitory effect of estradiol was blocked by the simultaneous addition of puromycin in the culture medium. © 1981 Birkhäuser Verlag. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00144754_v37_n2_p203_Cardinali
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic 5 methoxytryptophol
estradiol
melatonin
puromycin
radioisotope
serotonin
animal experiment
drug metabolism
endocrine system
in vitro study
organ culture
pineal body
rat
Animal
Dose-Response Relationship, Drug
Estradiol
Organ Culture
Pineal Gland
Puromycin
Rats
Serotonin
Support, Non-U.S. Gov't
spellingShingle 5 methoxytryptophol
estradiol
melatonin
puromycin
radioisotope
serotonin
animal experiment
drug metabolism
endocrine system
in vitro study
organ culture
pineal body
rat
Animal
Dose-Response Relationship, Drug
Estradiol
Organ Culture
Pineal Gland
Puromycin
Rats
Serotonin
Support, Non-U.S. Gov't
Cardinali, D.P.
Vacas, M.I.
Ritta, M.N.
A biphasic effect of estradiol on serotonin metabolism in rat pineal organ cultures
topic_facet 5 methoxytryptophol
estradiol
melatonin
puromycin
radioisotope
serotonin
animal experiment
drug metabolism
endocrine system
in vitro study
organ culture
pineal body
rat
Animal
Dose-Response Relationship, Drug
Estradiol
Organ Culture
Pineal Gland
Puromycin
Rats
Serotonin
Support, Non-U.S. Gov't
description Physiological amounts of estradiol (1 nM) significantly increased serotonin, conversion to melatonin and 5-methoxytryptophol by rat pineal glands in organ culture whereas larger, pharmacological, doses (i.e. 1000 nM) impaired it significantly. The stimulatory but not the inhibitory effect of estradiol was blocked by the simultaneous addition of puromycin in the culture medium. © 1981 Birkhäuser Verlag.
format JOUR
author Cardinali, D.P.
Vacas, M.I.
Ritta, M.N.
author_facet Cardinali, D.P.
Vacas, M.I.
Ritta, M.N.
author_sort Cardinali, D.P.
title A biphasic effect of estradiol on serotonin metabolism in rat pineal organ cultures
title_short A biphasic effect of estradiol on serotonin metabolism in rat pineal organ cultures
title_full A biphasic effect of estradiol on serotonin metabolism in rat pineal organ cultures
title_fullStr A biphasic effect of estradiol on serotonin metabolism in rat pineal organ cultures
title_full_unstemmed A biphasic effect of estradiol on serotonin metabolism in rat pineal organ cultures
title_sort biphasic effect of estradiol on serotonin metabolism in rat pineal organ cultures
url http://hdl.handle.net/20.500.12110/paper_00144754_v37_n2_p203_Cardinali
work_keys_str_mv AT cardinalidp abiphasiceffectofestradiolonserotoninmetabolisminratpinealorgancultures
AT vacasmi abiphasiceffectofestradiolonserotoninmetabolisminratpinealorgancultures
AT rittamn abiphasiceffectofestradiolonserotoninmetabolisminratpinealorgancultures
AT cardinalidp biphasiceffectofestradiolonserotoninmetabolisminratpinealorgancultures
AT vacasmi biphasiceffectofestradiolonserotoninmetabolisminratpinealorgancultures
AT rittamn biphasiceffectofestradiolonserotoninmetabolisminratpinealorgancultures
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