Effect of pentoxifylline and aminophylline on biogenic amine metabolism of the rat brain
In the brain of rats injected with pentoxifylline [3,7-dimethyl-1(5-oxo-hexyl)-xanthine] or aminophylline the following was observed: (i) dose-dependent increases of tryptophan and 5-droxyindoleacetic acid levels and of 5-hydroxytryptophan and dihydroxyphenylalanine accumulation after treatment with...
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todo:paper_00142999_v47_n2_p239_Cardinali2023-10-03T14:12:07Z Effect of pentoxifylline and aminophylline on biogenic amine metabolism of the rat brain Cardinali, D.P. 5-Hydroxyindoleacetic acid Aminophylline Catecholamine turnover Methylxanthines Tryptophan and tyrosine hydroxylation 5 hydroxyindoleacetic acid 5 hydroxytryptophan amine aminophylline benserazide catecholamine dopa metirosine pargyline pentoxifylline serotonin tryptophan tryptophan hydroxylase tyrosine 3 monooxygenase animal experiment brain catecholamine brain level catecholamine metabolism central nervous system column chromatography controlled study dose response dose time effect relation double blind procedure drug analysis drug comparison drug efficacy drug response in vitro study intraperitoneal drug administration methodology rat Aminophylline Animal Biogenic Amines Brain Dopamine Male Norepinephrine Pentoxifylline Rats Serotonin Theobromine In the brain of rats injected with pentoxifylline [3,7-dimethyl-1(5-oxo-hexyl)-xanthine] or aminophylline the following was observed: (i) dose-dependent increases of tryptophan and 5-droxyindoleacetic acid levels and of 5-hydroxytryptophan and dihydroxyphenylalanine accumulation after treatment with the decarboxylase inhibitor benserazide HCl; (ii) acceleration of norepinephrine turnover following α-methyl-p-tyrosine; (iii) increase of 3-methoxytyramine accumulation following pargyline. On a molar basis pentoxifylline was more potent than aminophylline in affecting brain biogenic amine metabolism. © 1978. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00142999_v47_n2_p239_Cardinali |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
5-Hydroxyindoleacetic acid Aminophylline Catecholamine turnover Methylxanthines Tryptophan and tyrosine hydroxylation 5 hydroxyindoleacetic acid 5 hydroxytryptophan amine aminophylline benserazide catecholamine dopa metirosine pargyline pentoxifylline serotonin tryptophan tryptophan hydroxylase tyrosine 3 monooxygenase animal experiment brain catecholamine brain level catecholamine metabolism central nervous system column chromatography controlled study dose response dose time effect relation double blind procedure drug analysis drug comparison drug efficacy drug response in vitro study intraperitoneal drug administration methodology rat Aminophylline Animal Biogenic Amines Brain Dopamine Male Norepinephrine Pentoxifylline Rats Serotonin Theobromine |
| spellingShingle |
5-Hydroxyindoleacetic acid Aminophylline Catecholamine turnover Methylxanthines Tryptophan and tyrosine hydroxylation 5 hydroxyindoleacetic acid 5 hydroxytryptophan amine aminophylline benserazide catecholamine dopa metirosine pargyline pentoxifylline serotonin tryptophan tryptophan hydroxylase tyrosine 3 monooxygenase animal experiment brain catecholamine brain level catecholamine metabolism central nervous system column chromatography controlled study dose response dose time effect relation double blind procedure drug analysis drug comparison drug efficacy drug response in vitro study intraperitoneal drug administration methodology rat Aminophylline Animal Biogenic Amines Brain Dopamine Male Norepinephrine Pentoxifylline Rats Serotonin Theobromine Cardinali, D.P. Effect of pentoxifylline and aminophylline on biogenic amine metabolism of the rat brain |
| topic_facet |
5-Hydroxyindoleacetic acid Aminophylline Catecholamine turnover Methylxanthines Tryptophan and tyrosine hydroxylation 5 hydroxyindoleacetic acid 5 hydroxytryptophan amine aminophylline benserazide catecholamine dopa metirosine pargyline pentoxifylline serotonin tryptophan tryptophan hydroxylase tyrosine 3 monooxygenase animal experiment brain catecholamine brain level catecholamine metabolism central nervous system column chromatography controlled study dose response dose time effect relation double blind procedure drug analysis drug comparison drug efficacy drug response in vitro study intraperitoneal drug administration methodology rat Aminophylline Animal Biogenic Amines Brain Dopamine Male Norepinephrine Pentoxifylline Rats Serotonin Theobromine |
| description |
In the brain of rats injected with pentoxifylline [3,7-dimethyl-1(5-oxo-hexyl)-xanthine] or aminophylline the following was observed: (i) dose-dependent increases of tryptophan and 5-droxyindoleacetic acid levels and of 5-hydroxytryptophan and dihydroxyphenylalanine accumulation after treatment with the decarboxylase inhibitor benserazide HCl; (ii) acceleration of norepinephrine turnover following α-methyl-p-tyrosine; (iii) increase of 3-methoxytyramine accumulation following pargyline. On a molar basis pentoxifylline was more potent than aminophylline in affecting brain biogenic amine metabolism. © 1978. |
| format |
JOUR |
| author |
Cardinali, D.P. |
| author_facet |
Cardinali, D.P. |
| author_sort |
Cardinali, D.P. |
| title |
Effect of pentoxifylline and aminophylline on biogenic amine metabolism of the rat brain |
| title_short |
Effect of pentoxifylline and aminophylline on biogenic amine metabolism of the rat brain |
| title_full |
Effect of pentoxifylline and aminophylline on biogenic amine metabolism of the rat brain |
| title_fullStr |
Effect of pentoxifylline and aminophylline on biogenic amine metabolism of the rat brain |
| title_full_unstemmed |
Effect of pentoxifylline and aminophylline on biogenic amine metabolism of the rat brain |
| title_sort |
effect of pentoxifylline and aminophylline on biogenic amine metabolism of the rat brain |
| url |
http://hdl.handle.net/20.500.12110/paper_00142999_v47_n2_p239_Cardinali |
| work_keys_str_mv |
AT cardinalidp effectofpentoxifyllineandaminophyllineonbiogenicaminemetabolismoftheratbrain |
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1807316403943899136 |