The gp130 cytokines interleukin-11 and ciliary neurotropic factor regulate through specific receptors the function and growth of lactosomatotropic and folliculostellate pituitary cell lines

Two of the most potent cytokines regulating anterior pituitary cell function are leukemia inhibitory factor and interleukin-6 (IL-6), which belong to the cytokine receptor family using the common gp130 signal transducer. We studied the actions of two other members of this family, IL-11 and ciliary n...

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Autores principales: Castro, C.P., Nagashima, A.C., Pereda, M.P., Goldberg, V., Chervin, A., Largen, P., Renner, U., Stalla, G.K., Arzt, E.
Formato: JOUR
Materias:
ciliary neurotrophic factor
ciliary neurotrophic factor receptor
cytokine
glycoprotein gp 130
interleukin 11
interleukin 11 receptor
leukemia inhibitory factor
vasculotropin
adenohypophysis
alpha chain
angiogenesis
animal cell
article
cell proliferation
controlled study
dose response
hormone synthesis
hypophysis cell
nonhuman
priority journal
rat
regulatory mechanism
signal transduction
stellate cell
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00137227_v141_n5_p1746_Castro
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_00137227_v141_n5_p1746_Castro
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spelling todo:paper_00137227_v141_n5_p1746_Castro2023-10-03T14:11:14Z The gp130 cytokines interleukin-11 and ciliary neurotropic factor regulate through specific receptors the function and growth of lactosomatotropic and folliculostellate pituitary cell lines Castro, C.P. Nagashima, A.C. Pereda, M.P. Goldberg, V. Chervin, A. Largen, P. Renner, U. Stalla, G.K. Arzt, E. ciliary neurotrophic factor ciliary neurotrophic factor receptor cytokine glycoprotein gp 130 interleukin 11 interleukin 11 receptor leukemia inhibitory factor vasculotropin adenohypophysis alpha chain angiogenesis animal cell article cell proliferation controlled study dose response hormone synthesis hypophysis cell nonhuman priority journal rat regulatory mechanism signal transduction stellate cell Two of the most potent cytokines regulating anterior pituitary cell function are leukemia inhibitory factor and interleukin-6 (IL-6), which belong to the cytokine receptor family using the common gp130 signal transducer. We studied the actions of two other members of this family, IL-11 and ciliary neurotropic factor (CNTF), on folliculostellate (FS) cells (TtT/GF cell line) and lactosomatotropic cells (GH3 cell line). The messenger RNA (mRNA) for the α-chain specific for the IL-11 receptor (1.7 kb) and CNTF receptor (2 kb) are expressed on both cell types. In addition, we detected CNTF receptor mRNA in normal rat anterior pituitary cells. IL-11 (1.25-5 nM) dose dependently stimulated the proliferation of FS cells. CNTF, at doses from 0.4-2 nM, also significantly stimulated the growth of these cells. In addition, both cytokines significantly stimulated proliferation of lactosomatotropic GH3 cells, and CNTF stimulated hormone production (GH and PRL) at 24 h by these cells. At 16-72 h, IL-11 stimulates the secretion of the angiogenic factor vascular endothelial growth factor by FS cells. In addition, both GH3 and FS cells express CNTF mRNA. These data suggest that IL-11 and CNTF may act as growth and regulatory factors in anterior pituitary cells. Fil:Pereda, M.P. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00137227_v141_n5_p1746_Castro
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic ciliary neurotrophic factor
ciliary neurotrophic factor receptor
cytokine
glycoprotein gp 130
interleukin 11
interleukin 11 receptor
leukemia inhibitory factor
vasculotropin
adenohypophysis
alpha chain
angiogenesis
animal cell
article
cell proliferation
controlled study
dose response
hormone synthesis
hypophysis cell
nonhuman
priority journal
rat
regulatory mechanism
signal transduction
stellate cell
spellingShingle ciliary neurotrophic factor
ciliary neurotrophic factor receptor
cytokine
glycoprotein gp 130
interleukin 11
interleukin 11 receptor
leukemia inhibitory factor
vasculotropin
adenohypophysis
alpha chain
angiogenesis
animal cell
article
cell proliferation
controlled study
dose response
hormone synthesis
hypophysis cell
nonhuman
priority journal
rat
regulatory mechanism
signal transduction
stellate cell
Castro, C.P.
Nagashima, A.C.
Pereda, M.P.
Goldberg, V.
Chervin, A.
Largen, P.
Renner, U.
Stalla, G.K.
Arzt, E.
The gp130 cytokines interleukin-11 and ciliary neurotropic factor regulate through specific receptors the function and growth of lactosomatotropic and folliculostellate pituitary cell lines
topic_facet ciliary neurotrophic factor
ciliary neurotrophic factor receptor
cytokine
glycoprotein gp 130
interleukin 11
interleukin 11 receptor
leukemia inhibitory factor
vasculotropin
adenohypophysis
alpha chain
angiogenesis
animal cell
article
cell proliferation
controlled study
dose response
hormone synthesis
hypophysis cell
nonhuman
priority journal
rat
regulatory mechanism
signal transduction
stellate cell
description Two of the most potent cytokines regulating anterior pituitary cell function are leukemia inhibitory factor and interleukin-6 (IL-6), which belong to the cytokine receptor family using the common gp130 signal transducer. We studied the actions of two other members of this family, IL-11 and ciliary neurotropic factor (CNTF), on folliculostellate (FS) cells (TtT/GF cell line) and lactosomatotropic cells (GH3 cell line). The messenger RNA (mRNA) for the α-chain specific for the IL-11 receptor (1.7 kb) and CNTF receptor (2 kb) are expressed on both cell types. In addition, we detected CNTF receptor mRNA in normal rat anterior pituitary cells. IL-11 (1.25-5 nM) dose dependently stimulated the proliferation of FS cells. CNTF, at doses from 0.4-2 nM, also significantly stimulated the growth of these cells. In addition, both cytokines significantly stimulated proliferation of lactosomatotropic GH3 cells, and CNTF stimulated hormone production (GH and PRL) at 24 h by these cells. At 16-72 h, IL-11 stimulates the secretion of the angiogenic factor vascular endothelial growth factor by FS cells. In addition, both GH3 and FS cells express CNTF mRNA. These data suggest that IL-11 and CNTF may act as growth and regulatory factors in anterior pituitary cells.
format JOUR
author Castro, C.P.
Nagashima, A.C.
Pereda, M.P.
Goldberg, V.
Chervin, A.
Largen, P.
Renner, U.
Stalla, G.K.
Arzt, E.
author_facet Castro, C.P.
Nagashima, A.C.
Pereda, M.P.
Goldberg, V.
Chervin, A.
Largen, P.
Renner, U.
Stalla, G.K.
Arzt, E.
author_sort Castro, C.P.
title The gp130 cytokines interleukin-11 and ciliary neurotropic factor regulate through specific receptors the function and growth of lactosomatotropic and folliculostellate pituitary cell lines
title_short The gp130 cytokines interleukin-11 and ciliary neurotropic factor regulate through specific receptors the function and growth of lactosomatotropic and folliculostellate pituitary cell lines
title_full The gp130 cytokines interleukin-11 and ciliary neurotropic factor regulate through specific receptors the function and growth of lactosomatotropic and folliculostellate pituitary cell lines
title_fullStr The gp130 cytokines interleukin-11 and ciliary neurotropic factor regulate through specific receptors the function and growth of lactosomatotropic and folliculostellate pituitary cell lines
title_full_unstemmed The gp130 cytokines interleukin-11 and ciliary neurotropic factor regulate through specific receptors the function and growth of lactosomatotropic and folliculostellate pituitary cell lines
title_sort gp130 cytokines interleukin-11 and ciliary neurotropic factor regulate through specific receptors the function and growth of lactosomatotropic and folliculostellate pituitary cell lines
url http://hdl.handle.net/20.500.12110/paper_00137227_v141_n5_p1746_Castro
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