Potential role of mononuclear cells infiltration on the autoimmune myocardial dysfunction
In autoimmune myocarditis significant alterations in contractility when the heart is studied in vitro could be demonstrated. The isolated atria from mice hyperimmunized with heart exhibited tachycardia, decrease in contractility and dysrhythmia. Spleen lymphocytes from mice with autoimmune myocardit...
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_00099104_v63_n3_p648_Leiros |
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todo:paper_00099104_v63_n3_p648_Leiros2023-10-03T14:08:50Z Potential role of mononuclear cells infiltration on the autoimmune myocardial dysfunction Leiros, C.P. Sterin-Borda, L. Cossio, P. animal experiment autoimmune disease dysrhythmia etiology heart heart disease lymphocytic infiltration mouse myocarditis nonhuman priority journal tachycardia Animal Autoimmune Diseases Cell Movement Disease Models, Animal Heart Atrium Lymphocytes Mice Myocardial Contraction Myocarditis Myocardium Spleen Support, Non-U.S. Gov't Time Factors In autoimmune myocarditis significant alterations in contractility when the heart is studied in vitro could be demonstrated. The isolated atria from mice hyperimmunized with heart exhibited tachycardia, decrease in contractility and dysrhythmia. Spleen lymphocytes from mice with autoimmune myocarditis, can react in vitro with spontaneously beating normal atria inducing dysrhythmias and negative inotropic effect. The alterations in contractility of normal atria induced by immune cells, resemble those observed in atria from animals with autoimmune myocarditis. The use of pharmacologic inhibitors strongly suggests that the cardiac dysfunction is generated by the release of endogenous SRS-A as a result of the hyperimmunization with heart. The possibility that autoimmune lymphocyte can influence the contractile behaviour of the heart is interesting and could provide some evidence for the role of lymphocytic infiltration in the mechanism operating in primary and specific myocarditis. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00099104_v63_n3_p648_Leiros |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
animal experiment autoimmune disease dysrhythmia etiology heart heart disease lymphocytic infiltration mouse myocarditis nonhuman priority journal tachycardia Animal Autoimmune Diseases Cell Movement Disease Models, Animal Heart Atrium Lymphocytes Mice Myocardial Contraction Myocarditis Myocardium Spleen Support, Non-U.S. Gov't Time Factors |
| spellingShingle |
animal experiment autoimmune disease dysrhythmia etiology heart heart disease lymphocytic infiltration mouse myocarditis nonhuman priority journal tachycardia Animal Autoimmune Diseases Cell Movement Disease Models, Animal Heart Atrium Lymphocytes Mice Myocardial Contraction Myocarditis Myocardium Spleen Support, Non-U.S. Gov't Time Factors Leiros, C.P. Sterin-Borda, L. Cossio, P. Potential role of mononuclear cells infiltration on the autoimmune myocardial dysfunction |
| topic_facet |
animal experiment autoimmune disease dysrhythmia etiology heart heart disease lymphocytic infiltration mouse myocarditis nonhuman priority journal tachycardia Animal Autoimmune Diseases Cell Movement Disease Models, Animal Heart Atrium Lymphocytes Mice Myocardial Contraction Myocarditis Myocardium Spleen Support, Non-U.S. Gov't Time Factors |
| description |
In autoimmune myocarditis significant alterations in contractility when the heart is studied in vitro could be demonstrated. The isolated atria from mice hyperimmunized with heart exhibited tachycardia, decrease in contractility and dysrhythmia. Spleen lymphocytes from mice with autoimmune myocarditis, can react in vitro with spontaneously beating normal atria inducing dysrhythmias and negative inotropic effect. The alterations in contractility of normal atria induced by immune cells, resemble those observed in atria from animals with autoimmune myocarditis. The use of pharmacologic inhibitors strongly suggests that the cardiac dysfunction is generated by the release of endogenous SRS-A as a result of the hyperimmunization with heart. The possibility that autoimmune lymphocyte can influence the contractile behaviour of the heart is interesting and could provide some evidence for the role of lymphocytic infiltration in the mechanism operating in primary and specific myocarditis. |
| format |
JOUR |
| author |
Leiros, C.P. Sterin-Borda, L. Cossio, P. |
| author_facet |
Leiros, C.P. Sterin-Borda, L. Cossio, P. |
| author_sort |
Leiros, C.P. |
| title |
Potential role of mononuclear cells infiltration on the autoimmune myocardial dysfunction |
| title_short |
Potential role of mononuclear cells infiltration on the autoimmune myocardial dysfunction |
| title_full |
Potential role of mononuclear cells infiltration on the autoimmune myocardial dysfunction |
| title_fullStr |
Potential role of mononuclear cells infiltration on the autoimmune myocardial dysfunction |
| title_full_unstemmed |
Potential role of mononuclear cells infiltration on the autoimmune myocardial dysfunction |
| title_sort |
potential role of mononuclear cells infiltration on the autoimmune myocardial dysfunction |
| url |
http://hdl.handle.net/20.500.12110/paper_00099104_v63_n3_p648_Leiros |
| work_keys_str_mv |
AT leiroscp potentialroleofmononuclearcellsinfiltrationontheautoimmunemyocardialdysfunction AT sterinbordal potentialroleofmononuclearcellsinfiltrationontheautoimmunemyocardialdysfunction AT cossiop potentialroleofmononuclearcellsinfiltrationontheautoimmunemyocardialdysfunction |
| _version_ |
1807323455289294848 |