Experimental porphyria induced in rats by hexachloro-benzene. A study of the porphyrins excreted by urine

Severe porphyria was induced and maintained for several months in rats by means of daily hexachlorobenzene administration via stomach tube. Urinary porphyrins with 8-, 7-, 6-, 5- and 4-COOH were isolated and studied by column and paper Chromatographic techniques, both qualitative and quantitative, a...

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Autores principales:	de Viale, L.C.S.M., Viale, A.A., Nacht, S., Grinstein, M.
Formato:	JOUR
Materias:	benzene derivative chlorine insecticide lindane porphyrin animal article chromatography female human iatrogenic disease male metabolism microphotography paper chromatography porphyria rat spectrophotometry urine Animal Benzene Derivatives Chlorine Chromatography Chromatography, Paper Female Human Insecticides, Botanical Lindane Male Photomicrography Porphyria Porphyrins Rats Spectrophotometry
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_00098981_v28_n1_p13_deViale
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_00098981_v28_n1_p13_deViale
record_format	dspace
spelling	todo:paper_00098981_v28_n1_p13_deViale2023-10-03T14:08:43Z Experimental porphyria induced in rats by hexachloro-benzene. A study of the porphyrins excreted by urine de Viale, L.C.S.M. Viale, A.A. Nacht, S. Grinstein, M. benzene derivative chlorine insecticide lindane porphyrin animal article chromatography female human iatrogenic disease male metabolism microphotography paper chromatography porphyria rat spectrophotometry urine Animal Benzene Derivatives Chlorine Chromatography Chromatography, Paper Female Human Insecticides, Botanical Lindane Male Photomicrography Porphyria Porphyrins Rats Spectrophotometry Severe porphyria was induced and maintained for several months in rats by means of daily hexachlorobenzene administration via stomach tube. Urinary porphyrins with 8-, 7-, 6-, 5- and 4-COOH were isolated and studied by column and paper Chromatographic techniques, both qualitative and quantitative, and their absorption spectra and melting points were determined. It was found that the relative excretory pattern was: uroporphyrin > coproporphyrin > phyriaporphyrins > 5-COOH porphyrin > 6-COOH porphyrin. By chemical decarboxylation, all these porphyrins were found to be the type III isomer with only traces of uroporphyrin I and 5-COOH porphyrin I. The predominant porphyrins in the liver were uroporphyrin III and phyriaporphyrin. These findings were compared with those reported in humans intoxicated with the same chemical and with those in patients with hepatic porphyria cutanea tarda. The main differences among these groups were in the isomeric composition of the uroporphyrin, 5-COOH porphyrin and coproporphyrin. Porphyria induced in rats by hexachlorobenzene appears to provide a useful experimental approach for the study of the metabolic changes involved in human porphyria. © 1970. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00098981_v28_n1_p13_deViale
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	benzene derivative chlorine insecticide lindane porphyrin animal article chromatography female human iatrogenic disease male metabolism microphotography paper chromatography porphyria rat spectrophotometry urine Animal Benzene Derivatives Chlorine Chromatography Chromatography, Paper Female Human Insecticides, Botanical Lindane Male Photomicrography Porphyria Porphyrins Rats Spectrophotometry
spellingShingle	benzene derivative chlorine insecticide lindane porphyrin animal article chromatography female human iatrogenic disease male metabolism microphotography paper chromatography porphyria rat spectrophotometry urine Animal Benzene Derivatives Chlorine Chromatography Chromatography, Paper Female Human Insecticides, Botanical Lindane Male Photomicrography Porphyria Porphyrins Rats Spectrophotometry de Viale, L.C.S.M. Viale, A.A. Nacht, S. Grinstein, M. Experimental porphyria induced in rats by hexachloro-benzene. A study of the porphyrins excreted by urine
topic_facet	benzene derivative chlorine insecticide lindane porphyrin animal article chromatography female human iatrogenic disease male metabolism microphotography paper chromatography porphyria rat spectrophotometry urine Animal Benzene Derivatives Chlorine Chromatography Chromatography, Paper Female Human Insecticides, Botanical Lindane Male Photomicrography Porphyria Porphyrins Rats Spectrophotometry
description	Severe porphyria was induced and maintained for several months in rats by means of daily hexachlorobenzene administration via stomach tube. Urinary porphyrins with 8-, 7-, 6-, 5- and 4-COOH were isolated and studied by column and paper Chromatographic techniques, both qualitative and quantitative, and their absorption spectra and melting points were determined. It was found that the relative excretory pattern was: uroporphyrin > coproporphyrin > phyriaporphyrins > 5-COOH porphyrin > 6-COOH porphyrin. By chemical decarboxylation, all these porphyrins were found to be the type III isomer with only traces of uroporphyrin I and 5-COOH porphyrin I. The predominant porphyrins in the liver were uroporphyrin III and phyriaporphyrin. These findings were compared with those reported in humans intoxicated with the same chemical and with those in patients with hepatic porphyria cutanea tarda. The main differences among these groups were in the isomeric composition of the uroporphyrin, 5-COOH porphyrin and coproporphyrin. Porphyria induced in rats by hexachlorobenzene appears to provide a useful experimental approach for the study of the metabolic changes involved in human porphyria. © 1970.
format	JOUR
author	de Viale, L.C.S.M. Viale, A.A. Nacht, S. Grinstein, M.
author_facet	de Viale, L.C.S.M. Viale, A.A. Nacht, S. Grinstein, M.
author_sort	de Viale, L.C.S.M.
title	Experimental porphyria induced in rats by hexachloro-benzene. A study of the porphyrins excreted by urine
title_short	Experimental porphyria induced in rats by hexachloro-benzene. A study of the porphyrins excreted by urine
title_full	Experimental porphyria induced in rats by hexachloro-benzene. A study of the porphyrins excreted by urine
title_fullStr	Experimental porphyria induced in rats by hexachloro-benzene. A study of the porphyrins excreted by urine
title_full_unstemmed	Experimental porphyria induced in rats by hexachloro-benzene. A study of the porphyrins excreted by urine
title_sort	experimental porphyria induced in rats by hexachloro-benzene. a study of the porphyrins excreted by urine
url	http://hdl.handle.net/20.500.12110/paper_00098981_v28_n1_p13_deViale
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Experimental porphyria induced in rats by hexachloro-benzene. A study of the porphyrins excreted by urine

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