Role of plasma procalcitonin determination in the postoperative follow-up of cephalic pancreatoduodenectomy
Background. Procalcitonin (PCT) is widely accepted as an early marker of the severity of sepsis and its prognosis. This study was designed to evaluate the utility of PCT in the early diagnosis of immediate postoperative complications (infectious and non-infectious) following cephalic pancreatoduoden...
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todo:paper_0009739X_v79_n6_p356_Bianchi2023-10-03T14:08:41Z Role of plasma procalcitonin determination in the postoperative follow-up of cephalic pancreatoduodenectomy Bianchi, R.A. Haedo, A.S. Romero, M.C. Pancreatoduodenectomy Postoperative outcome Procalcitonin calcitonin procalcitonin protein precursor adult aged article blood female follow up human male methodology middle aged pancreaticoduodenectomy postoperative care postoperative complication prediction and forecasting preoperative care prospective study sepsis Adult Aged Calcitonin Female Follow-Up Studies Humans Male Middle Aged Pancreaticoduodenectomy Postoperative Care Postoperative Complications Predictive Value of Tests Preoperative Care Prospective Studies Protein Precursors Sepsis Background. Procalcitonin (PCT) is widely accepted as an early marker of the severity of sepsis and its prognosis. This study was designed to evaluate the utility of PCT in the early diagnosis of immediate postoperative complications (infectious and non-infectious) following cephalic pancreatoduodenectomy (PD). Patients and method. Thirty-one patients who underwent elective PD were prospectively analyzed. The patients were divided into two groups according to the presence or absence of postoperative complications. Plasma PCT concentrations were determined by an immunochromatographic method. The correlation between PCT concentrations and the presence of complications, as well as the existence of statistically significant differences in PCT concentrations between the 2 groups of patients, were analyzed. The value of plasma PCT concentrations in predicting complications compared with that of other biochemical variables (C-reactive protein, lactic acid, base excess) and clinical parameters (systemic inflammatory response syndrome) was analyzed. Results. Significant differences in PCT concentrations were found between the two groups. An inverse correlation between marker levels and patient outcome was observed. The variables that best predicted the development of complications were PCT concentrations and axillary temperature. Conclusions. Plasma PCT should be taken into account as a useful marker for postoperative clinical course in the follow-up of PD and for the early detection of non-infectious complications. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_0009739X_v79_n6_p356_Bianchi |
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Universidad de Buenos Aires |
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I-28 |
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R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Pancreatoduodenectomy Postoperative outcome Procalcitonin calcitonin procalcitonin protein precursor adult aged article blood female follow up human male methodology middle aged pancreaticoduodenectomy postoperative care postoperative complication prediction and forecasting preoperative care prospective study sepsis Adult Aged Calcitonin Female Follow-Up Studies Humans Male Middle Aged Pancreaticoduodenectomy Postoperative Care Postoperative Complications Predictive Value of Tests Preoperative Care Prospective Studies Protein Precursors Sepsis |
| spellingShingle |
Pancreatoduodenectomy Postoperative outcome Procalcitonin calcitonin procalcitonin protein precursor adult aged article blood female follow up human male methodology middle aged pancreaticoduodenectomy postoperative care postoperative complication prediction and forecasting preoperative care prospective study sepsis Adult Aged Calcitonin Female Follow-Up Studies Humans Male Middle Aged Pancreaticoduodenectomy Postoperative Care Postoperative Complications Predictive Value of Tests Preoperative Care Prospective Studies Protein Precursors Sepsis Bianchi, R.A. Haedo, A.S. Romero, M.C. Role of plasma procalcitonin determination in the postoperative follow-up of cephalic pancreatoduodenectomy |
| topic_facet |
Pancreatoduodenectomy Postoperative outcome Procalcitonin calcitonin procalcitonin protein precursor adult aged article blood female follow up human male methodology middle aged pancreaticoduodenectomy postoperative care postoperative complication prediction and forecasting preoperative care prospective study sepsis Adult Aged Calcitonin Female Follow-Up Studies Humans Male Middle Aged Pancreaticoduodenectomy Postoperative Care Postoperative Complications Predictive Value of Tests Preoperative Care Prospective Studies Protein Precursors Sepsis |
| description |
Background. Procalcitonin (PCT) is widely accepted as an early marker of the severity of sepsis and its prognosis. This study was designed to evaluate the utility of PCT in the early diagnosis of immediate postoperative complications (infectious and non-infectious) following cephalic pancreatoduodenectomy (PD). Patients and method. Thirty-one patients who underwent elective PD were prospectively analyzed. The patients were divided into two groups according to the presence or absence of postoperative complications. Plasma PCT concentrations were determined by an immunochromatographic method. The correlation between PCT concentrations and the presence of complications, as well as the existence of statistically significant differences in PCT concentrations between the 2 groups of patients, were analyzed. The value of plasma PCT concentrations in predicting complications compared with that of other biochemical variables (C-reactive protein, lactic acid, base excess) and clinical parameters (systemic inflammatory response syndrome) was analyzed. Results. Significant differences in PCT concentrations were found between the two groups. An inverse correlation between marker levels and patient outcome was observed. The variables that best predicted the development of complications were PCT concentrations and axillary temperature. Conclusions. Plasma PCT should be taken into account as a useful marker for postoperative clinical course in the follow-up of PD and for the early detection of non-infectious complications. |
| format |
JOUR |
| author |
Bianchi, R.A. Haedo, A.S. Romero, M.C. |
| author_facet |
Bianchi, R.A. Haedo, A.S. Romero, M.C. |
| author_sort |
Bianchi, R.A. |
| title |
Role of plasma procalcitonin determination in the postoperative follow-up of cephalic pancreatoduodenectomy |
| title_short |
Role of plasma procalcitonin determination in the postoperative follow-up of cephalic pancreatoduodenectomy |
| title_full |
Role of plasma procalcitonin determination in the postoperative follow-up of cephalic pancreatoduodenectomy |
| title_fullStr |
Role of plasma procalcitonin determination in the postoperative follow-up of cephalic pancreatoduodenectomy |
| title_full_unstemmed |
Role of plasma procalcitonin determination in the postoperative follow-up of cephalic pancreatoduodenectomy |
| title_sort |
role of plasma procalcitonin determination in the postoperative follow-up of cephalic pancreatoduodenectomy |
| url |
http://hdl.handle.net/20.500.12110/paper_0009739X_v79_n6_p356_Bianchi |
| work_keys_str_mv |
AT bianchira roleofplasmaprocalcitonindeterminationinthepostoperativefollowupofcephalicpancreatoduodenectomy AT haedoas roleofplasmaprocalcitonindeterminationinthepostoperativefollowupofcephalicpancreatoduodenectomy AT romeromc roleofplasmaprocalcitonindeterminationinthepostoperativefollowupofcephalicpancreatoduodenectomy |
| _version_ |
1807320110508015616 |