Electric field effects on the reactivity of heme model systems

Proteins integrated or transiently bound to membranes are subject to strong electric fields. However, the role of these fields on tuning the reactivity of redox proteins is still an open issue. High electric fields are also present in protein-based electrochemical devices. In this work we report DFT...

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Detalles Bibliográficos
Autores principales: De Biase, P.M., Doctorovich, F., Murgida, D.H., Estrin, D.A.
Formato: JOUR
Materias:
Electric field effects
Electrochemistry
Porphyrins
Proteins
Redox reactions
Heme proteins
Ligand binding
Redox proteins
Pigments
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00092614_v434_n1-3_p121_DeBiase
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_00092614_v434_n1-3_p121_DeBiase
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spelling todo:paper_00092614_v434_n1-3_p121_DeBiase2023-10-03T14:08:26Z Electric field effects on the reactivity of heme model systems De Biase, P.M. Doctorovich, F. Murgida, D.H. Estrin, D.A. Electric field effects Electrochemistry Porphyrins Proteins Redox reactions Heme proteins Ligand binding Redox proteins Pigments Proteins integrated or transiently bound to membranes are subject to strong electric fields. However, the role of these fields on tuning the reactivity of redox proteins is still an open issue. High electric fields are also present in protein-based electrochemical devices. In this work we report DFT calculations of the electric field effects on ligand binding and on the redox potentials of porphyrin models representing the active sites of typical heme proteins such as cytochrome c, cytochrome c oxidase, cytochrome c peroxidase and cytochrome P450. © 2006 Elsevier B.V. All rights reserved. Fil:De Biase, P.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Doctorovich, F. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Murgida, D.H. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Estrin, D.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00092614_v434_n1-3_p121_DeBiase
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Electric field effects
Electrochemistry
Porphyrins
Proteins
Redox reactions
Heme proteins
Ligand binding
Redox proteins
Pigments
spellingShingle Electric field effects
Electrochemistry
Porphyrins
Proteins
Redox reactions
Heme proteins
Ligand binding
Redox proteins
Pigments
De Biase, P.M.
Doctorovich, F.
Murgida, D.H.
Estrin, D.A.
Electric field effects on the reactivity of heme model systems
topic_facet Electric field effects
Electrochemistry
Porphyrins
Proteins
Redox reactions
Heme proteins
Ligand binding
Redox proteins
Pigments
description Proteins integrated or transiently bound to membranes are subject to strong electric fields. However, the role of these fields on tuning the reactivity of redox proteins is still an open issue. High electric fields are also present in protein-based electrochemical devices. In this work we report DFT calculations of the electric field effects on ligand binding and on the redox potentials of porphyrin models representing the active sites of typical heme proteins such as cytochrome c, cytochrome c oxidase, cytochrome c peroxidase and cytochrome P450. © 2006 Elsevier B.V. All rights reserved.
format JOUR
author De Biase, P.M.
Doctorovich, F.
Murgida, D.H.
Estrin, D.A.
author_facet De Biase, P.M.
Doctorovich, F.
Murgida, D.H.
Estrin, D.A.
author_sort De Biase, P.M.
title Electric field effects on the reactivity of heme model systems
title_short Electric field effects on the reactivity of heme model systems
title_full Electric field effects on the reactivity of heme model systems
title_fullStr Electric field effects on the reactivity of heme model systems
title_full_unstemmed Electric field effects on the reactivity of heme model systems
title_sort electric field effects on the reactivity of heme model systems
url http://hdl.handle.net/20.500.12110/paper_00092614_v434_n1-3_p121_DeBiase
work_keys_str_mv AT debiasepm electricfieldeffectsonthereactivityofhememodelsystems
AT doctorovichf electricfieldeffectsonthereactivityofhememodelsystems
AT murgidadh electricfieldeffectsonthereactivityofhememodelsystems
AT estrinda electricfieldeffectsonthereactivityofhememodelsystems
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