The expression of progesterone receptors coincides with an arrest of DNA synthesis in human breast cancer
Two main models to account for the heterogeneous expression of estrogen receptors (ER) and progesterone receptors (PR) in human breast cancer have been proposed: the clonal model and the stem cell model. The authors previously provided evidence supporting the stem cell model since it was found that...
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todo:paper_0008543X_v67_n5_p1352_Ballare2023-10-03T14:06:10Z The expression of progesterone receptors coincides with an arrest of DNA synthesis in human breast cancer Ballare, C. Bravo, A.I. Sorin, I. Guman, N. Schiaffi, J.A. Yomha, R. Bagnati, A. Lema, B. Mordoh, J. progesterone receptor antigen expression article autoradiography breast cancer clinical article dna synthesis female growth inhibition human human tissue immunohistochemistry priority journal Breast Neoplasms Carcinoma DNA Replication DNA, Neoplasm Female Human Immunohistochemistry Receptors, Estrogen Receptors, Progesterone Reproducibility of Results Support, Non-U.S. Gov't Two main models to account for the heterogeneous expression of estrogen receptors (ER) and progesterone receptors (PR) in human breast cancer have been proposed: the clonal model and the stem cell model. The authors previously provided evidence supporting the stem cell model since it was found that most of the proliferating cells in ER‐positive (ER+) human breast cancer lack ER and that the ER‐negative (ER−) and ER+ subpopulations are interrelated. The authors have analyzed in eighteen ER+/PR+ primary breast tumors the simultaneous expression of ER or PR (by immunohistochemistry) and DNA synthesis (by autoradiography) after 30 minutes of 3H‐thymidine incorporation. The authors demonstrated that: (1) the average numbers of ER+ and PR+ cells were similar (36.8 ± 10.7% and 39.3 ± 17.6%, respectively); (2) The thymidine‐labeling indexes of the ER+, ER−, PR+, and PR− subpopulations were 0.53 ± 0.69%, 0.74 ± 0.49%, 0.21 ± 0.21 and 0.94 ± 0.54%, respectively; and (3) 75.2% of the DNA‐synthesizing cells were ER−, and 88.8% of them were PR−. The authors conclude that the cellular subpopulations expressing ER and PR were not identical, and the expression of PR was associated with a lower rate of cellular proliferation than was ER expression. Copyright © 1991 American Cancer Society Fil:Ballare, C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_0008543X_v67_n5_p1352_Ballare |
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Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
progesterone receptor antigen expression article autoradiography breast cancer clinical article dna synthesis female growth inhibition human human tissue immunohistochemistry priority journal Breast Neoplasms Carcinoma DNA Replication DNA, Neoplasm Female Human Immunohistochemistry Receptors, Estrogen Receptors, Progesterone Reproducibility of Results Support, Non-U.S. Gov't |
| spellingShingle |
progesterone receptor antigen expression article autoradiography breast cancer clinical article dna synthesis female growth inhibition human human tissue immunohistochemistry priority journal Breast Neoplasms Carcinoma DNA Replication DNA, Neoplasm Female Human Immunohistochemistry Receptors, Estrogen Receptors, Progesterone Reproducibility of Results Support, Non-U.S. Gov't Ballare, C. Bravo, A.I. Sorin, I. Guman, N. Schiaffi, J.A. Yomha, R. Bagnati, A. Lema, B. Mordoh, J. The expression of progesterone receptors coincides with an arrest of DNA synthesis in human breast cancer |
| topic_facet |
progesterone receptor antigen expression article autoradiography breast cancer clinical article dna synthesis female growth inhibition human human tissue immunohistochemistry priority journal Breast Neoplasms Carcinoma DNA Replication DNA, Neoplasm Female Human Immunohistochemistry Receptors, Estrogen Receptors, Progesterone Reproducibility of Results Support, Non-U.S. Gov't |
| description |
Two main models to account for the heterogeneous expression of estrogen receptors (ER) and progesterone receptors (PR) in human breast cancer have been proposed: the clonal model and the stem cell model. The authors previously provided evidence supporting the stem cell model since it was found that most of the proliferating cells in ER‐positive (ER+) human breast cancer lack ER and that the ER‐negative (ER−) and ER+ subpopulations are interrelated. The authors have analyzed in eighteen ER+/PR+ primary breast tumors the simultaneous expression of ER or PR (by immunohistochemistry) and DNA synthesis (by autoradiography) after 30 minutes of 3H‐thymidine incorporation. The authors demonstrated that: (1) the average numbers of ER+ and PR+ cells were similar (36.8 ± 10.7% and 39.3 ± 17.6%, respectively); (2) The thymidine‐labeling indexes of the ER+, ER−, PR+, and PR− subpopulations were 0.53 ± 0.69%, 0.74 ± 0.49%, 0.21 ± 0.21 and 0.94 ± 0.54%, respectively; and (3) 75.2% of the DNA‐synthesizing cells were ER−, and 88.8% of them were PR−. The authors conclude that the cellular subpopulations expressing ER and PR were not identical, and the expression of PR was associated with a lower rate of cellular proliferation than was ER expression. Copyright © 1991 American Cancer Society |
| format |
JOUR |
| author |
Ballare, C. Bravo, A.I. Sorin, I. Guman, N. Schiaffi, J.A. Yomha, R. Bagnati, A. Lema, B. Mordoh, J. |
| author_facet |
Ballare, C. Bravo, A.I. Sorin, I. Guman, N. Schiaffi, J.A. Yomha, R. Bagnati, A. Lema, B. Mordoh, J. |
| author_sort |
Ballare, C. |
| title |
The expression of progesterone receptors coincides with an arrest of DNA synthesis in human breast cancer |
| title_short |
The expression of progesterone receptors coincides with an arrest of DNA synthesis in human breast cancer |
| title_full |
The expression of progesterone receptors coincides with an arrest of DNA synthesis in human breast cancer |
| title_fullStr |
The expression of progesterone receptors coincides with an arrest of DNA synthesis in human breast cancer |
| title_full_unstemmed |
The expression of progesterone receptors coincides with an arrest of DNA synthesis in human breast cancer |
| title_sort |
expression of progesterone receptors coincides with an arrest of dna synthesis in human breast cancer |
| url |
http://hdl.handle.net/20.500.12110/paper_0008543X_v67_n5_p1352_Ballare |
| work_keys_str_mv |
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