Diabetes alters the reactivity of myocardium to a thromboxane analogue

Atrial contractile response to U-46619 was studied in auricles from normal and acutely diabetic rats. U-46619 induced an increment of dF/dt in diabetic atria, whereas nondiabetic auricles elicited a negative contractile effect. Blockers of arachidonic acid metabolism via cyclooxygenase inhibited the...

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Autores principales: Canga, L., Gorelik, G., Sterin-Borda, L.
Formato: JOUR
Materias:
1 acetyl 2 (8 chloro 10,11 dihydrodibenz[b,f][1,4]oxazepine 10 carbonyl)hydrazine
15 hydroxy 11alpha,9alpha epoxymethanoprosta 5,13 dienoic acid
acetylsalicylic acid
dithizone
imidazole
indometacin
lipoxygenase
nictindole
nordihydroguaiaretic acid
prostaglandin synthase
thromboxane derivative
tranylcypromine
animal
animal cell
diabetes mellitus
dose response
drug administration
drug antagonism
drug efficacy
drug interaction
drug mechanism
endocrine system
etiology
heart
heart muscle
heart muscle contractility
in vitro study
pharmacokinetics
priority journal
rat
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00084212_v65_n4_p499_Canga
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_00084212_v65_n4_p499_Canga
record_format dspace
spelling todo:paper_00084212_v65_n4_p499_Canga2023-10-03T14:06:04Z Diabetes alters the reactivity of myocardium to a thromboxane analogue Canga, L. Gorelik, G. Sterin-Borda, L. 1 acetyl 2 (8 chloro 10,11 dihydrodibenz[b,f][1,4]oxazepine 10 carbonyl)hydrazine 15 hydroxy 11alpha,9alpha epoxymethanoprosta 5,13 dienoic acid acetylsalicylic acid dithizone imidazole indometacin lipoxygenase nictindole nordihydroguaiaretic acid prostaglandin synthase thromboxane derivative tranylcypromine animal animal cell diabetes mellitus dose response drug administration drug antagonism drug efficacy drug interaction drug mechanism endocrine system etiology heart heart muscle heart muscle contractility in vitro study pharmacokinetics priority journal rat Atrial contractile response to U-46619 was studied in auricles from normal and acutely diabetic rats. U-46619 induced an increment of dF/dt in diabetic atria, whereas nondiabetic auricles elicited a negative contractile effect. Blockers of arachidonic acid metabolism via cyclooxygenase inhibited the stimulatory action of U-46619 in diabetic preparations. Moreover, inhibitors of thromboxane synthesis completely blocked the stimulatory effects of U-46619. The stimulant action of the thromboxane A2 mimetic was attenuated when diabetic auricles were incubated with lipoxygenase(s) blocking agents. Results suggest that in diabetic atria the abnormal inotropic effect induced by U-46619 may be associated with thromboxane formation and with lipoxygenase(s) metabolites. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00084212_v65_n4_p499_Canga
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic 1 acetyl 2 (8 chloro 10,11 dihydrodibenz[b,f][1,4]oxazepine 10 carbonyl)hydrazine
15 hydroxy 11alpha,9alpha epoxymethanoprosta 5,13 dienoic acid
acetylsalicylic acid
dithizone
imidazole
indometacin
lipoxygenase
nictindole
nordihydroguaiaretic acid
prostaglandin synthase
thromboxane derivative
tranylcypromine
animal
animal cell
diabetes mellitus
dose response
drug administration
drug antagonism
drug efficacy
drug interaction
drug mechanism
endocrine system
etiology
heart
heart muscle
heart muscle contractility
in vitro study
pharmacokinetics
priority journal
rat
spellingShingle 1 acetyl 2 (8 chloro 10,11 dihydrodibenz[b,f][1,4]oxazepine 10 carbonyl)hydrazine
15 hydroxy 11alpha,9alpha epoxymethanoprosta 5,13 dienoic acid
acetylsalicylic acid
dithizone
imidazole
indometacin
lipoxygenase
nictindole
nordihydroguaiaretic acid
prostaglandin synthase
thromboxane derivative
tranylcypromine
animal
animal cell
diabetes mellitus
dose response
drug administration
drug antagonism
drug efficacy
drug interaction
drug mechanism
endocrine system
etiology
heart
heart muscle
heart muscle contractility
in vitro study
pharmacokinetics
priority journal
rat
Canga, L.
Gorelik, G.
Sterin-Borda, L.
Diabetes alters the reactivity of myocardium to a thromboxane analogue
topic_facet 1 acetyl 2 (8 chloro 10,11 dihydrodibenz[b,f][1,4]oxazepine 10 carbonyl)hydrazine
15 hydroxy 11alpha,9alpha epoxymethanoprosta 5,13 dienoic acid
acetylsalicylic acid
dithizone
imidazole
indometacin
lipoxygenase
nictindole
nordihydroguaiaretic acid
prostaglandin synthase
thromboxane derivative
tranylcypromine
animal
animal cell
diabetes mellitus
dose response
drug administration
drug antagonism
drug efficacy
drug interaction
drug mechanism
endocrine system
etiology
heart
heart muscle
heart muscle contractility
in vitro study
pharmacokinetics
priority journal
rat
description Atrial contractile response to U-46619 was studied in auricles from normal and acutely diabetic rats. U-46619 induced an increment of dF/dt in diabetic atria, whereas nondiabetic auricles elicited a negative contractile effect. Blockers of arachidonic acid metabolism via cyclooxygenase inhibited the stimulatory action of U-46619 in diabetic preparations. Moreover, inhibitors of thromboxane synthesis completely blocked the stimulatory effects of U-46619. The stimulant action of the thromboxane A2 mimetic was attenuated when diabetic auricles were incubated with lipoxygenase(s) blocking agents. Results suggest that in diabetic atria the abnormal inotropic effect induced by U-46619 may be associated with thromboxane formation and with lipoxygenase(s) metabolites.
format JOUR
author Canga, L.
Gorelik, G.
Sterin-Borda, L.
author_facet Canga, L.
Gorelik, G.
Sterin-Borda, L.
author_sort Canga, L.
title Diabetes alters the reactivity of myocardium to a thromboxane analogue
title_short Diabetes alters the reactivity of myocardium to a thromboxane analogue
title_full Diabetes alters the reactivity of myocardium to a thromboxane analogue
title_fullStr Diabetes alters the reactivity of myocardium to a thromboxane analogue
title_full_unstemmed Diabetes alters the reactivity of myocardium to a thromboxane analogue
title_sort diabetes alters the reactivity of myocardium to a thromboxane analogue
url http://hdl.handle.net/20.500.12110/paper_00084212_v65_n4_p499_Canga
work_keys_str_mv AT cangal diabetesaltersthereactivityofmyocardiumtoathromboxaneanalogue
AT gorelikg diabetesaltersthereactivityofmyocardiumtoathromboxaneanalogue
AT sterinbordal diabetesaltersthereactivityofmyocardiumtoathromboxaneanalogue
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