Melatonin increases cGMP and decreases cAMP levels in rat medial basal hypothalamus in vitro

Measurement of cyclic nucleotide accumulation in rat medial basal hypothalamus (MBH) incubated in vitro with methoxyindoles indicated that melatonin (10-8 M or greater) increased significantly cGMP and depressed cAMP levels. Only the effect on MBH cAMP was shared by 5-methoxytryptophol which exhibit...

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Detalles Bibliográficos
Autores principales: Vacas, M.I., Keller Sarmiento, M.I., Cardinali, D.P.
Formato: JOUR
Materias:
5-methoxytryptophol
cAMP
cGMP
medial basal hypothalamus
melatonin
pineal gland
5 methoxytryptophol
6 hydroxymelatonin
cyclic amp
cyclic gmp
6 fluoromelatonin
animal experiment
central nervous system
hypothalamus
in vitro study
nervous system
pineal body
rat
Animal
Cyclic AMP
Cyclic GMP
Dose-Response Relationship, Drug
Hypothalamus
Male
Melatonin
Rats
Rats, Inbred Strains
Support, Non-U.S. Gov't
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00068993_v225_n1_p207_Vacas
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:Measurement of cyclic nucleotide accumulation in rat medial basal hypothalamus (MBH) incubated in vitro with methoxyindoles indicated that melatonin (10-8 M or greater) increased significantly cGMP and depressed cAMP levels. Only the effect on MBH cAMP was shared by 5-methoxytryptophol which exhibited a greater activity than melatonin. 6-Fluromelatonin (10-7 M) increased cGMP, whereas the effect of 6-hydroxymelatonin was not significant. Both 6-fluoro- and 6-hydroxymelatonin (10-5 M) depressed MBH cAMP accumulation while only 6-fluoromelatonin affected it at 10-7 M concentrations. These data suggest that melatonin and 5-methoxytryptophol affect differently cyclic nucleotide content of MBH at physiological concentrations. © 1981.

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