Melatonin increases cGMP and decreases cAMP levels in rat medial basal hypothalamus in vitro
Measurement of cyclic nucleotide accumulation in rat medial basal hypothalamus (MBH) incubated in vitro with methoxyindoles indicated that melatonin (10-8 M or greater) increased significantly cGMP and depressed cAMP levels. Only the effect on MBH cAMP was shared by 5-methoxytryptophol which exhibit...
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todo:paper_00068993_v225_n1_p207_Vacas2023-10-03T14:05:20Z Melatonin increases cGMP and decreases cAMP levels in rat medial basal hypothalamus in vitro Vacas, M.I. Keller Sarmiento, M.I. Cardinali, D.P. 5-methoxytryptophol cAMP cGMP medial basal hypothalamus melatonin pineal gland 5 methoxytryptophol 6 hydroxymelatonin cyclic amp cyclic gmp melatonin 6 fluoromelatonin animal experiment central nervous system hypothalamus in vitro study nervous system pineal body rat Animal Cyclic AMP Cyclic GMP Dose-Response Relationship, Drug Hypothalamus Male Melatonin Rats Rats, Inbred Strains Support, Non-U.S. Gov't Measurement of cyclic nucleotide accumulation in rat medial basal hypothalamus (MBH) incubated in vitro with methoxyindoles indicated that melatonin (10-8 M or greater) increased significantly cGMP and depressed cAMP levels. Only the effect on MBH cAMP was shared by 5-methoxytryptophol which exhibited a greater activity than melatonin. 6-Fluromelatonin (10-7 M) increased cGMP, whereas the effect of 6-hydroxymelatonin was not significant. Both 6-fluoro- and 6-hydroxymelatonin (10-5 M) depressed MBH cAMP accumulation while only 6-fluoromelatonin affected it at 10-7 M concentrations. These data suggest that melatonin and 5-methoxytryptophol affect differently cyclic nucleotide content of MBH at physiological concentrations. © 1981. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00068993_v225_n1_p207_Vacas |
| institution |
Universidad de Buenos Aires |
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I-28 |
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R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
5-methoxytryptophol cAMP cGMP medial basal hypothalamus melatonin pineal gland 5 methoxytryptophol 6 hydroxymelatonin cyclic amp cyclic gmp melatonin 6 fluoromelatonin animal experiment central nervous system hypothalamus in vitro study nervous system pineal body rat Animal Cyclic AMP Cyclic GMP Dose-Response Relationship, Drug Hypothalamus Male Melatonin Rats Rats, Inbred Strains Support, Non-U.S. Gov't |
| spellingShingle |
5-methoxytryptophol cAMP cGMP medial basal hypothalamus melatonin pineal gland 5 methoxytryptophol 6 hydroxymelatonin cyclic amp cyclic gmp melatonin 6 fluoromelatonin animal experiment central nervous system hypothalamus in vitro study nervous system pineal body rat Animal Cyclic AMP Cyclic GMP Dose-Response Relationship, Drug Hypothalamus Male Melatonin Rats Rats, Inbred Strains Support, Non-U.S. Gov't Vacas, M.I. Keller Sarmiento, M.I. Cardinali, D.P. Melatonin increases cGMP and decreases cAMP levels in rat medial basal hypothalamus in vitro |
| topic_facet |
5-methoxytryptophol cAMP cGMP medial basal hypothalamus melatonin pineal gland 5 methoxytryptophol 6 hydroxymelatonin cyclic amp cyclic gmp melatonin 6 fluoromelatonin animal experiment central nervous system hypothalamus in vitro study nervous system pineal body rat Animal Cyclic AMP Cyclic GMP Dose-Response Relationship, Drug Hypothalamus Male Melatonin Rats Rats, Inbred Strains Support, Non-U.S. Gov't |
| description |
Measurement of cyclic nucleotide accumulation in rat medial basal hypothalamus (MBH) incubated in vitro with methoxyindoles indicated that melatonin (10-8 M or greater) increased significantly cGMP and depressed cAMP levels. Only the effect on MBH cAMP was shared by 5-methoxytryptophol which exhibited a greater activity than melatonin. 6-Fluromelatonin (10-7 M) increased cGMP, whereas the effect of 6-hydroxymelatonin was not significant. Both 6-fluoro- and 6-hydroxymelatonin (10-5 M) depressed MBH cAMP accumulation while only 6-fluoromelatonin affected it at 10-7 M concentrations. These data suggest that melatonin and 5-methoxytryptophol affect differently cyclic nucleotide content of MBH at physiological concentrations. © 1981. |
| format |
JOUR |
| author |
Vacas, M.I. Keller Sarmiento, M.I. Cardinali, D.P. |
| author_facet |
Vacas, M.I. Keller Sarmiento, M.I. Cardinali, D.P. |
| author_sort |
Vacas, M.I. |
| title |
Melatonin increases cGMP and decreases cAMP levels in rat medial basal hypothalamus in vitro |
| title_short |
Melatonin increases cGMP and decreases cAMP levels in rat medial basal hypothalamus in vitro |
| title_full |
Melatonin increases cGMP and decreases cAMP levels in rat medial basal hypothalamus in vitro |
| title_fullStr |
Melatonin increases cGMP and decreases cAMP levels in rat medial basal hypothalamus in vitro |
| title_full_unstemmed |
Melatonin increases cGMP and decreases cAMP levels in rat medial basal hypothalamus in vitro |
| title_sort |
melatonin increases cgmp and decreases camp levels in rat medial basal hypothalamus in vitro |
| url |
http://hdl.handle.net/20.500.12110/paper_00068993_v225_n1_p207_Vacas |
| work_keys_str_mv |
AT vacasmi melatoninincreasescgmpanddecreasescamplevelsinratmedialbasalhypothalamusinvitro AT kellersarmientomi melatoninincreasescgmpanddecreasescamplevelsinratmedialbasalhypothalamusinvitro AT cardinalidp melatoninincreasescgmpanddecreasescamplevelsinratmedialbasalhypothalamusinvitro |
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1807314761983983616 |