Saltatory and Continuous Calcium Waves and the Rapid Buffering Approximation

Calcium waves propagate inside cells due to a regenerative mechanism known as calcium-induced calcium release. Buffer-mediated calcium diffusion in the cytosol plays a crucial role in the process. However, most models of calcium waves either treat buffers phenomenologically or assume that they are i...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Strier, D.E., Ventura, A.C., Dawson, S.P.
Formato:	JOUR
Materias:	calcium channel calcium ion article calcium cell level calcium signaling calcium transport cytosol intracellular transport phenomenology
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_00063495_v85_n6_p3575_Strier
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_00063495_v85_n6_p3575_Strier
record_format	dspace
spelling	todo:paper_00063495_v85_n6_p3575_Strier2023-10-03T14:05:07Z Saltatory and Continuous Calcium Waves and the Rapid Buffering Approximation Strier, D.E. Ventura, A.C. Dawson, S.P. calcium channel calcium ion article calcium cell level calcium signaling calcium transport cytosol intracellular transport phenomenology Calcium waves propagate inside cells due to a regenerative mechanism known as calcium-induced calcium release. Buffer-mediated calcium diffusion in the cytosol plays a crucial role in the process. However, most models of calcium waves either treat buffers phenomenologically or assume that they are in equilibrium with calcium (the rapid buffering approximation). In this article we address the issue of whether this approximation provides a good description of wave propagation. We first compare the timescales present in the problem, and determine the situations in which the equilibrium hypothesis fails. We then present a series of numerical studies based on the simple fire-diffuse-fire model of wave propagation. We find that the differences between the full and reduced descriptions may lead to errors that are above experimental resolution even for relatively fast buffers in the case of saltatory waves. Conversely, in the case of continuous waves, the approximation may give accurate results even for relatively slow buffers. Fil:Strier, D.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Ventura, A.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Dawson, S.P. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00063495_v85_n6_p3575_Strier
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	calcium channel calcium ion article calcium cell level calcium signaling calcium transport cytosol intracellular transport phenomenology
spellingShingle	calcium channel calcium ion article calcium cell level calcium signaling calcium transport cytosol intracellular transport phenomenology Strier, D.E. Ventura, A.C. Dawson, S.P. Saltatory and Continuous Calcium Waves and the Rapid Buffering Approximation
topic_facet	calcium channel calcium ion article calcium cell level calcium signaling calcium transport cytosol intracellular transport phenomenology
description	Calcium waves propagate inside cells due to a regenerative mechanism known as calcium-induced calcium release. Buffer-mediated calcium diffusion in the cytosol plays a crucial role in the process. However, most models of calcium waves either treat buffers phenomenologically or assume that they are in equilibrium with calcium (the rapid buffering approximation). In this article we address the issue of whether this approximation provides a good description of wave propagation. We first compare the timescales present in the problem, and determine the situations in which the equilibrium hypothesis fails. We then present a series of numerical studies based on the simple fire-diffuse-fire model of wave propagation. We find that the differences between the full and reduced descriptions may lead to errors that are above experimental resolution even for relatively fast buffers in the case of saltatory waves. Conversely, in the case of continuous waves, the approximation may give accurate results even for relatively slow buffers.
format	JOUR
author	Strier, D.E. Ventura, A.C. Dawson, S.P.
author_facet	Strier, D.E. Ventura, A.C. Dawson, S.P.
author_sort	Strier, D.E.
title	Saltatory and Continuous Calcium Waves and the Rapid Buffering Approximation
title_short	Saltatory and Continuous Calcium Waves and the Rapid Buffering Approximation
title_full	Saltatory and Continuous Calcium Waves and the Rapid Buffering Approximation
title_fullStr	Saltatory and Continuous Calcium Waves and the Rapid Buffering Approximation
title_full_unstemmed	Saltatory and Continuous Calcium Waves and the Rapid Buffering Approximation
title_sort	saltatory and continuous calcium waves and the rapid buffering approximation
url	http://hdl.handle.net/20.500.12110/paper_00063495_v85_n6_p3575_Strier
work_keys_str_mv	AT strierde saltatoryandcontinuouscalciumwavesandtherapidbufferingapproximation AT venturaac saltatoryandcontinuouscalciumwavesandtherapidbufferingapproximation AT dawsonsp saltatoryandcontinuouscalciumwavesandtherapidbufferingapproximation
_version_	1782027847027654656

Saltatory and Continuous Calcium Waves and the Rapid Buffering Approximation

Ejemplares similares