Thyroid function and thyroxine metabolism in hexachlorobenzene-induced porphyria

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The effects of hexachlorobenzene (HCB) administration on the development of porphyria and on changes in thyroid function and thyroid hormone metabolism were examined. Female Wistar rats were treated with HCB for 1 or 8 weeks. At both treatment times liver weight was notably increased with a slight c...

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Autores principales:	Kleiman De Pisarev, D.L., Del Carmen Rios De Molina, M., San Martin De Viale, L.C.
Formato:	JOUR
Materias:	5 aminolevulinate synthase hexachlorobenzene propylthiouracil radioisotope thyroxine animal experiment article female liothyronine blood level liver weight nonhuman porphyria priority journal protein bound iodine rat thyroid function thyrotropin blood level thyroxine blood level thyroxine metabolism 5-Aminolevulinate Synthetase Animal Body Weight Chlorobenzenes Dose-Response Relationship, Drug Female Hexachlorobenzene Iodine Radioisotopes Liver Organ Weight Porphyria Porphyrins Rats Rats, Inbred Strains Support, Non-U.S. Gov't Thyroid Gland Thyroxine Triiodothyronine
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_00062952_v39_n5_p817_KleimanDePisarev
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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spelling	todo:paper_00062952_v39_n5_p817_KleimanDePisarev2023-10-03T14:04:16Z Thyroid function and thyroxine metabolism in hexachlorobenzene-induced porphyria Kleiman De Pisarev, D.L. Del Carmen Rios De Molina, M. San Martin De Viale, L.C. 5 aminolevulinate synthase hexachlorobenzene propylthiouracil radioisotope thyroxine animal experiment article female liothyronine blood level liver weight nonhuman porphyria priority journal protein bound iodine rat thyroid function thyrotropin blood level thyroxine blood level thyroxine metabolism 5-Aminolevulinate Synthetase Animal Body Weight Chlorobenzenes Dose-Response Relationship, Drug Female Hexachlorobenzene Iodine Radioisotopes Liver Organ Weight Porphyria Porphyrins Rats Rats, Inbred Strains Support, Non-U.S. Gov't Thyroid Gland Thyroxine Triiodothyronine The effects of hexachlorobenzene (HCB) administration on the development of porphyria and on changes in thyroid function and thyroid hormone metabolism were examined. Female Wistar rats were treated with HCB for 1 or 8 weeks. At both treatment times liver weight was notably increased with a slight change in thyroid weight at 8 weeks. Serum thyroxine (T4) levels were depressed, whereas levels of triiodothyronine (T3) were not depressed significantly at both treatment times. One or eight weeks of HCB treatment did not alter the incorporation and distribution of [125I] into intrathyroidal aminoacids. A 50% reduction in protein bound iodine (PB[125I]) was seen in both groups of animals. HCB altered [125I]T4 metabolism in rat liver slices, increasing T4 dehalogenation. HCB administration for 1 week did not affect urinary excretion of porphyrins or their precursors, or hepatic porphyrin content. The activity of aminolaevulinate synthase was not affected, but there was a 25% and 51% inhibition in porphyrinogen carboxy-lyase (PCL) activity for the uroporphyrinogen disappearance or the coproporphyrinogen formation respectively. After 8 weeks of HCB administration the rats showed a characteristic porphyria. Our results show that HCB treatment increased hepatic thyroxine metabolism, without alterations in thyroid hormone synthesis. Serum T4 and PCL activity behaved differently in both time- and dose-dependent studies, with serum T4 being the more sensitive parameter which responded at earlier times and lower doses. © 1990. Fil:Kleiman De Pisarev, D.L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Del Carmen Rios De Molina, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:San Martin De Viale, L.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00062952_v39_n5_p817_KleimanDePisarev
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	5 aminolevulinate synthase hexachlorobenzene propylthiouracil radioisotope thyroxine animal experiment article female liothyronine blood level liver weight nonhuman porphyria priority journal protein bound iodine rat thyroid function thyrotropin blood level thyroxine blood level thyroxine metabolism 5-Aminolevulinate Synthetase Animal Body Weight Chlorobenzenes Dose-Response Relationship, Drug Female Hexachlorobenzene Iodine Radioisotopes Liver Organ Weight Porphyria Porphyrins Rats Rats, Inbred Strains Support, Non-U.S. Gov't Thyroid Gland Thyroxine Triiodothyronine
spellingShingle	5 aminolevulinate synthase hexachlorobenzene propylthiouracil radioisotope thyroxine animal experiment article female liothyronine blood level liver weight nonhuman porphyria priority journal protein bound iodine rat thyroid function thyrotropin blood level thyroxine blood level thyroxine metabolism 5-Aminolevulinate Synthetase Animal Body Weight Chlorobenzenes Dose-Response Relationship, Drug Female Hexachlorobenzene Iodine Radioisotopes Liver Organ Weight Porphyria Porphyrins Rats Rats, Inbred Strains Support, Non-U.S. Gov't Thyroid Gland Thyroxine Triiodothyronine Kleiman De Pisarev, D.L. Del Carmen Rios De Molina, M. San Martin De Viale, L.C. Thyroid function and thyroxine metabolism in hexachlorobenzene-induced porphyria
topic_facet	5 aminolevulinate synthase hexachlorobenzene propylthiouracil radioisotope thyroxine animal experiment article female liothyronine blood level liver weight nonhuman porphyria priority journal protein bound iodine rat thyroid function thyrotropin blood level thyroxine blood level thyroxine metabolism 5-Aminolevulinate Synthetase Animal Body Weight Chlorobenzenes Dose-Response Relationship, Drug Female Hexachlorobenzene Iodine Radioisotopes Liver Organ Weight Porphyria Porphyrins Rats Rats, Inbred Strains Support, Non-U.S. Gov't Thyroid Gland Thyroxine Triiodothyronine
description	The effects of hexachlorobenzene (HCB) administration on the development of porphyria and on changes in thyroid function and thyroid hormone metabolism were examined. Female Wistar rats were treated with HCB for 1 or 8 weeks. At both treatment times liver weight was notably increased with a slight change in thyroid weight at 8 weeks. Serum thyroxine (T4) levels were depressed, whereas levels of triiodothyronine (T3) were not depressed significantly at both treatment times. One or eight weeks of HCB treatment did not alter the incorporation and distribution of [125I] into intrathyroidal aminoacids. A 50% reduction in protein bound iodine (PB[125I]) was seen in both groups of animals. HCB altered [125I]T4 metabolism in rat liver slices, increasing T4 dehalogenation. HCB administration for 1 week did not affect urinary excretion of porphyrins or their precursors, or hepatic porphyrin content. The activity of aminolaevulinate synthase was not affected, but there was a 25% and 51% inhibition in porphyrinogen carboxy-lyase (PCL) activity for the uroporphyrinogen disappearance or the coproporphyrinogen formation respectively. After 8 weeks of HCB administration the rats showed a characteristic porphyria. Our results show that HCB treatment increased hepatic thyroxine metabolism, without alterations in thyroid hormone synthesis. Serum T4 and PCL activity behaved differently in both time- and dose-dependent studies, with serum T4 being the more sensitive parameter which responded at earlier times and lower doses. © 1990.
format	JOUR
author	Kleiman De Pisarev, D.L. Del Carmen Rios De Molina, M. San Martin De Viale, L.C.
author_facet	Kleiman De Pisarev, D.L. Del Carmen Rios De Molina, M. San Martin De Viale, L.C.
author_sort	Kleiman De Pisarev, D.L.
title	Thyroid function and thyroxine metabolism in hexachlorobenzene-induced porphyria
title_short	Thyroid function and thyroxine metabolism in hexachlorobenzene-induced porphyria
title_full	Thyroid function and thyroxine metabolism in hexachlorobenzene-induced porphyria
title_fullStr	Thyroid function and thyroxine metabolism in hexachlorobenzene-induced porphyria
title_full_unstemmed	Thyroid function and thyroxine metabolism in hexachlorobenzene-induced porphyria
title_sort	thyroid function and thyroxine metabolism in hexachlorobenzene-induced porphyria
url	http://hdl.handle.net/20.500.12110/paper_00062952_v39_n5_p817_KleimanDePisarev
work_keys_str_mv	AT kleimandepisarevdl thyroidfunctionandthyroxinemetabolisminhexachlorobenzeneinducedporphyria AT delcarmenriosdemolinam thyroidfunctionandthyroxinemetabolisminhexachlorobenzeneinducedporphyria AT sanmartindevialelc thyroidfunctionandthyroxinemetabolisminhexachlorobenzeneinducedporphyria
_version_	1807321588177043456

Thyroid function and thyroxine metabolism in hexachlorobenzene-induced porphyria

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